Nitrogen-Doped Carbon Supported Co/Ni Bimetallic Catalyst for Selectively Reductive N-Formylation of Nitroso in Guanine Synthesis

Abstract

A nitrogen-doped carbon supported Co/Ni bimetallic catalyst 2wt%Co/Ni@NC-700-10 was prepared and found to be efficient in the reductive N-formylation of 2,4-diamino-5-nitroso-6-hydroxypyrimidine (DANHP) to 2,4-diamino-5-formyl-6-hydroxypyrimidine (DAFHP) for the synthesis of guanine. Under optimal conditions, the conversion of DANHP reached up to 95.6% with a DAFHP selectivity of 97.6%. The characterization results revealed that the cobalt/nickel nanoparticles of the catalyst uniformly dispersed and encapsulated in the nitrogen-dopped carbon, and the catalyst has the characters of large surface area, as well as uniform dispersion and small diameters of metal nanoparticles in the form of Co/Ni alloy, which endowed its good catalytic performance in the reaction.

Synthesis of an MXene supported Co nanoparticle catalyst for efficient catalytic transfer hydrogenation of nitro compounds with formic acid

“…Conversely, the utilization of non-noble metal catalysts for the transfer hydrogenation of nitroarenes remains relatively limited, with only a handful of instances reported (refer to entries 5–10 in Table 1). 1,4,12,13,58,62 Remarkably, the catalytic efficiency of the 2.6% Co/MXene catalyst was found to be comparable to that of previously studied non-noble transition metal catalysts. These collective findings strongly indicate that the Co nanoparticles, which are uniformly distributed within the 3D porous MXene framework, exhibit exceptional catalytic activity in facilitating the transfer hydrogenation reaction of nitroarenes with the assistance of FA.…”

“…[8][9][10][11] Additionally, employing CO 2 as a carbonyl source in the catalytic transfer hydrogenation of anilines using transition metal oxides is well-established, yet often necessitates precious metals and stringent conditions. 12,13 Aryl amines, vital feedstocks in these processes, are typically produced by reducing nitroarenes with transition metals under elevated hydrogen pressures. This situation underscores the critical need to develop effective non-precious metal catalysts that can enable direct transfer hydrogenation of nitroarenes to the targeted formamide compounds, utilizing FA as both a hydrogen donor and a formylating agent.…”

Design of N‐Doped Carbon Materials Assisted Co−CoOx Anchoring on Mesoporous Silica Spheres Catalyst for Levulinic Acid Valorization

“…As shown in Figure 1 both two N 2 sorption isotherms exhibited typical type IV isotherm with obvious hysteresis loops, which attributed to the mesoporous structure of the supports [21] . Furthermore, it can be clearly seen (Table 1) that the specific surface area and pore volume of the catalyst were decreased due to blocking of a part of the channels and occupation of a part of the surface after doping with carbon nitride.…”

“…As shown in Figure 1 both two N 2 sorption isotherms exhibited typical type IV isotherm with obvious hysteresis loops, which attributed to the mesoporous structure of the supports. [21] Furthermore, it can be clearly seen (Table 1) that the specific surface area and pore volume of the catalyst were decreased due to blocking of a part of the channels and occupation of a part of the surface after doping with carbon nitride. Nevertheless, the average pore size of the catalysts was all about 2.6 nm, which indicates that the suggestion of N-doped carbon did not obviously influence the pore size distribution of the catalysts (Figure 1).…”