Nitrogen-doped carbon dots for sensitive detection of ferric ions and monohydrogen phosphate by the naked eye and imaging in living cells

Liu, Qiaoling; Ren, Borong; Xie, Kai‐Xin; Yan, Yanmei; Liu, Ruirong; Lv, Shiyou; He, Qing; Yang, Bo‐Ru; Li, Lin

doi:10.1039/d0na00769b

Cited by 16 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are attributed to CvO, C-O/C-OH, and OvC-OH bonding, respectively. 39 The XPS data are consistent with the FTIR data, providing convincing evidence for the nature of the functional groups on the surface of the CDs for CDP and CDM.…”

Section: Size and Structuresupporting

confidence: 75%

High-yield, one-pot upcycling of polyethylene and polypropylene waste into blue-emissive carbon dots

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Size and Structuresupporting

confidence: 75%

High-yield, one-pot upcycling of polyethylene and polypropylene waste into blue-emissive carbon dots

et al. 2023

View full text Add to dashboard Cite

show abstract

“…CDs have been adopted for intracellular phosphate detection due to that phosphate can restore the quenched fluorescence of CDs by Fe 3þ . [276,277] Liu et al fabricated nitrogen-doped CDs (N-CDs) via hydrothermal treatment of formamide and o-phenylenediamine, which exhibited antiphotobleaching property, good water dispersity, and excellent biocompatibility (Figure 11A). [277] The fluorescence of N-CDs was quenched by the addition of Fe 3þ , which could be recovered quickly in the presence of monohydrogen phosphate (HPO 4 2À ) through the formation of the stable N-CDs-Fe 3þ -HPO 4 2À complex.…”

Section: Anionsmentioning

confidence: 99%

“…[276,277] Liu et al fabricated nitrogen-doped CDs (N-CDs) via hydrothermal treatment of formamide and o-phenylenediamine, which exhibited antiphotobleaching property, good water dispersity, and excellent biocompatibility (Figure 11A). [277] The fluorescence of N-CDs was quenched by the addition of Fe 3þ , which could be recovered quickly in the presence of monohydrogen phosphate (HPO 4 2À ) through the formation of the stable N-CDs-Fe 3þ -HPO 4 2À complex. Therefore, N-CDs could detect HPO 4 2with a linear detection range of 0-60 μM and a low LOD of 0.80 μM.…”

Section: Anionsmentioning

confidence: 99%

Section: For Detecting Intracellular Compoundsmentioning

confidence: 99%

“…A) Scheme showing the use of N-CDs as a nanoprobe for the measurement of Fe 3þ and HPO 42À via an "on-off-on" fluorescence mode. Reproduced with permission [277]. Copyright 2021, Royal Society of Chemistry.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Carbon Dots for Intracellular Sensing

Lin

Jia

2022

Small Structures

View full text Add to dashboard Cite

Carbon dots (CDs), a type of small, carbon element‐based nanomaterials, have found numerous applications in many fields due to their outstanding properties like fascinating photoluminescence characteristic, great biocompatibility, easy and economical synthesis, and facile functionalization. Over the last decade, huge progress and achievements have been made in terms of the applications of CDs in cellular detection. However, a comprehensive review focusing on this topic is still lacking. Herein, the recent progress in CDs‐mediated intracellular detection, including the fluorescence imaging of cellular structures (e.g., nucleus/nucleolus, mitochondrion, lysosome, endoplasmic reticulum, Golgi apparatus, and lipid droplet), the fluorescence detection of a large variety of cellular substances (including endogenous biomacromolecules and their monomers, vitamins, important metabolites, adenosine triphosphate, reactive oxygen species, biothiols, ions, and exogenous compounds), and the monitoring of cellular parameters (pH, temperature, and mitochondrial membrane potential), is thoroughly reviewed. The synthesis, functionalization, and performance of the CDs that serve as fluorescent nanoprobes in living cells are presented. Their underlying working mechanisms are also discussed if available. Finally, the challenges and future research directions of the related research field are listed. This review may foster the future development of more CDs with better cellular sensing performance.

show abstract

A signal‐switchable fluorescent probe for detection of HPO₄²⁻ based on 5,10,15,20‐(4‐sulphonatophenyl)porphyrin (TPPS₄)

Mu,

Li,

Wang

et al. 2023

Luminescence

View full text Add to dashboard Cite

In this study, 5,10,15,20‐(4‐sulphonatophenyl)porphyrin (TPPS4) was selected as a fluorescent probe due to its excellent characteristics including high quantum yield, good water solubility, and exceptional biocompatibility. With an excitation wavelength set at 515 nm, the optimal fluorescence emission wavelength for TPPS4 was measured at 642 nm. At this moment, the fluorescence signal of TPPS4 pink solution was in the ‘ON’ state. The fluorescence intensity of TPPS4 was quenched when ascorbic acid (AA) was introduced, which was due to the electron transfer quenching effect between AA and TPPS4. The colour of the corresponding solution changed from pink to green, and the fluorescence signal was in the ‘OFF’ state. When HPO42− was further introduced into the TPPS4–AA system, the quenched fluorescence intensity of TPPS4 was recovered due to the unique interaction between HPO42− and AA. At this time, the colour of the corresponding solution changed from green to red, and the fluorescence signal was in the ‘ON’ state. Therefore, an ‘ON–OFF–ON’ signal‐switchable fluorescent probe was constructed based on TPPS4 to detect HPO42−. The results showed that the linear range of HPO42− was 4.0 × 10−9 to 1.7 × 10−6 M, and the detection limit was 1.3 × 10−9 M (S/N = 3). The sensing system exhibited high accuracy and sensitivity, and it could be used successfully to detect HPO42− in real samples.

show abstract

Nitrogen-doped carbon dots for sensitive detection of ferric ions and monohydrogen phosphate by the naked eye and imaging in living cells

Abstract: Nitrogen doped carbon dots (N-CDs) have been prepared via a one-pot hydrothermal method by using formamide and o-phenylenediamine as the carbon precursors for Fe3+ and HPO42− detection.

Cited by 16 publications

References 40 publications

High-yield, one-pot upcycling of polyethylene and polypropylene waste into blue-emissive carbon dots

High-yield, one-pot upcycling of polyethylene and polypropylene waste into blue-emissive carbon dots

Carbon Dots for Intracellular Sensing

A signal‐switchable fluorescent probe for detection of HPO₄²⁻ based on 5,10,15,20‐(4‐sulphonatophenyl)porphyrin (TPPS₄)

Contact Info

Product

Resources

About

Nitrogen-doped carbon dots for sensitive detection of ferric ions and monohydrogen phosphate by the naked eye and imaging in living cells

Abstract: Nitrogen doped carbon dots (N-CDs) have been prepared via a one-pot hydrothermal method by using formamide and o-phenylenediamine as the carbon precursors for Fe3+ and HPO42− detection.

Cited by 16 publications

References 40 publications

High-yield, one-pot upcycling of polyethylene and polypropylene waste into blue-emissive carbon dots

High-yield, one-pot upcycling of polyethylene and polypropylene waste into blue-emissive carbon dots

Carbon Dots for Intracellular Sensing

A signal‐switchable fluorescent probe for detection of HPO42− based on 5,10,15,20‐(4‐sulphonatophenyl)porphyrin (TPPS4)

Contact Info

Product

Resources

About

A signal‐switchable fluorescent probe for detection of HPO₄²⁻ based on 5,10,15,20‐(4‐sulphonatophenyl)porphyrin (TPPS₄)