Nitrogen Analogues of Aldrin as Noncompetitive Antagonists of GABA&lt;sub&gt;A&lt;/sub&gt; Receptor

Ozoe, Yoshihisa; Matsumoto, K.; Mochida, Kazuo; Nakamura, Toshiie; Matsumura, Fumio

doi:10.1584/jpestics.20.317

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Molecular Toxicology Of Noncompetitive Chloride Ionophore Bl1

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“…Notably, diaza-aldrin (3 , Table 96.4), in which the unchlorinated double bond is replaced by -N 5 N-and which is probably converted into its N-oxide (4 , Table 96.4) in vivo, is much more toxic than dieldrin to some insects (Busvine, 1964;Soloway, 1965) but dieldrin-resistant insects are immune to it. Using the TBPS binding assay in rat brain membranes, it has recently been confirmed that this molecule inhibits the binding competitively and therefore interacts directly with the PTX binding site (Ozoe et al, 1995).…”

Section: Molecular Toxicology Of Noncompetitive Chloride Ionophore Blmentioning

confidence: 95%