Nitrofurantoin prophylaxis for bacteriuria and urinary tract infection in children with neurogenic bladder on intermittent catheterization

Schlager, Theresa A.; Anderson, Susan; Trudell, Julie; Hendley, J. Owen

doi:10.1016/s0022-3476(98)70364-6

Cited by 67 publications

(14 citation statements)

References 13 publications

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“…This study found fewer UTIs over 16 weeks but had significant adverse events with antibiotic therapy and warned against the risk of resistant organisms ( 4 ). Three additional cross-over RCTs supported the use of prophylactic antibiotics in children ( 5 , 6 ) and adults ( 7 ) with NB.…”

Section: Resultsmentioning

confidence: 99%

Systematic review and practice policy statements on urinary tract infection prevention in adults with spina bifida

Tradewell

Pariser

Nimeh

et al. 2018

Transl. Androl. Urol.

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Urinary tract infection (UTI) is a source of morbidity and healthcare costs in adults with spina bifida (ASB). UTI prevention strategies are often recommended, but the evidence of various approaches remains unclear. We performed a systematic review to inform a best practice policy statement for UTI prevention in ASB. On behalf of the Neurogenic Bladder Research Group (NBRG.org), we developed an a priori protocol and searched the published English literature for 30 outcomes questions addressing UTI prevention in ASB. The questions spanned the categories of antibiotics, oral supplements, bladder management factors and social support. Where there was little literature in ASB, we included literature from similar populations with neurogenic bladder (NB). Data was abstracted and then reviewed with recommendations made by consensus of all authors. Level of Evidence (LoE) and Grade of Recommendation (GoR) were according to the Oxford grading system. Of 6,433 articles identified by our search, we included 99 publications. There was sufficient evidence to support use of the following: saline bladder irrigation (LoE 1, GoR B), gentamicin bladder instillation (LoE 3, GoR C), single-use intermittent catheterization (IC) (LoE 2, GoR B), hydrophilic catheters for IC (LoE 2, GoR C), intradetrusor onabotulinumtoxinA injection (LoE 3, GoR C), hyaluronic acid (HA) instillation (LoE 1, GoR B), and care coordination (LoE 3, GoR C). There was sufficient evidence to recommend against use of the following: sterile IC (LoE 1, GoR B), oral antibiotic prophylaxis (LoE 2, GoR B), treatment of asymptomatic bacteriuria (LoE 2, GoR B), cranberry (LoE 2, GoR B), methenamine salts (LoE 1, GoR B), and ascorbic acid (LoE1, GoR B). There was insufficient evidence to make a recommendation for other outcomes. Overall, there are few studies in UTI prevention in the specific population of ASB. Research in populations similar to ASB helps to guide recommendations for UTI prevention in the challenging patient group of ASB. Future studies in UTI prevention specific to ASB are needed and should focus on areas shown to be of benefit in similar populations.

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Section: Resultsmentioning

confidence: 99%

Systematic review and practice policy statements on urinary tract infection prevention in adults with spina bifida

Tradewell

Pariser

Nimeh

et al. 2018

Transl. Androl. Urol.

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“…21 Evidence for the use of antibiotic prophylaxis for CISC users suffering recurrent UTI, the focus for this trial, has been summarised in a Cochrane review updated to September 2011. 22 The review found five small, low-quality RCTs [23][24][25][26][27] relevant to the present trial with a total of 363 participants. For the outcome of clinical UTI, two crossover trials involving children showed no difference, while one-third involving children in an unblinded, parallel-group design found an incidence density ratio of 0.69 (95% CI 0.55 to 0.87) in favour of prophylaxis using a variety of agents.…”

Section: Evidence For Use Of Antibiotic Prophylaxismentioning

confidence: 99%

Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT

Pickard

Chadwick

Oluboyede

et al. 2018

Health Technol Assess

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“…In the current study, all the children were on CIC and all were receiving LDCP. Studies examining the effect of LDCP on symptomatic UTI reported divergent results, with a reduction of the rate in some [ 26 ] and a higher number of infections in other cohorts [ 27 ]. Apart from that, many studies also showed that more resistant organisms may be selected out by long-term LDCP [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies examining the effect of LDCP on symptomatic UTI reported divergent results, with a reduction of the rate in some [ 26 ] and a higher number of infections in other cohorts [ 27 ]. Apart from that, many studies also showed that more resistant organisms may be selected out by long-term LDCP [ 26 ]. Therefore, we realize that the attitude towards long-term LDCP in our center should be reconsidered with respect to prevalence and duration of its administration.…”

Section: Discussionmentioning

confidence: 99%

Can We Further Improve the Quality of Nephro-Urological Care in Children with Myelomeningocele?

Miklaszewska

Korohoda

Zachwieja

et al. 2016

IJERPH

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Myelomeningocele (MMC) results from a failure of normal neural tube fusion in early fetal development. Retrospective, observational study of medical data of 54 children treated in Pediatric Nephrology and Urology Clinics for five years was performed. The following data were analyzed: serum creatinine, eGFR, urine analysis, renal scintigraphy (RS), renal ultrasound, and urodynamics. Mean age of studied population: 12.3 years, median of eGFR at the beginning and at the end of survey was 110.25 and 116.5 mL/min/1.73 m2 accordingly. Median of frequency of urinary tract infections (fUTI): 1.2 episodes/year. In 24 children: low-pressure, in 30 children: high-pressure bladder was noted. Vesicouretral reflux (VUR) was noted in 23 children (42.6%). fUTI were more common in high-grade VUR group. High-grade VURs were more common in group of patients with severe renal damage. At the end of the survey 11.1% children were qualified to higher stages of chronic kidney disease. Renal parenchyma damage progression in RS was noted in 22.2% children. Positive VUR history, febrile recurrent UTIs, bladder wall trabeculation, and older age of the patients constitute risk factors of abnormal renal scans. More than 2.0 febrile, symptomatic UTIs annually increase by 5.6-fold the risk of severe renal parenchyma damage after five years.

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Nitrofurantoin prophylaxis for bacteriuria and urinary tract infection in children with neurogenic bladder on intermittent catheterization

Cited by 67 publications

References 13 publications

Systematic review and practice policy statements on urinary tract infection prevention in adults with spina bifida

Systematic review and practice policy statements on urinary tract infection prevention in adults with spina bifida

Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT

Can We Further Improve the Quality of Nephro-Urological Care in Children with Myelomeningocele?

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