Nitrofurantoin-induced immune-mediated lung and liver disease

Milic, Rade; Plavec, Goran; Tufegdzic, Ivana; Tomic, Ilija; Sarac, Sanja; Lončarević, Olivera

doi:10.2298/vsp1206536m

Cited by 3 publications

(2 citation statements)

References 13 publications

(15 reference statements)

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“…We selected PubMed Central database articles focusing on published cases of concomitant nitrofurantoin-induced lung and liver disease, including adults with a pulmonary evaluation and liver biopsy (Table 1 ) [ 9 , 13 , 14 , 15 , 16 , 17 , 18 ]. Data showed elderly women with prolonged nitrofurantoin use, where fatigue and respiratory symptoms (as dyspnea and dry cough) precede jaundice for weeks to months.…”

Section: Discussionmentioning

confidence: 99%

Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease

Matos

Macedo

Mendes

et al. 2021

GE Port J Gastroenterol

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Antibiotics are known to cause adverse reactions, but multiple organ involvement associated with nonspecific symptoms can lead to a delay in diagnosis. A definitive correlation between each toxin and its effects is difficult to establish due to concomitant potential toxins in the circulation. This article highlights an uncommon case of concomitant nitrofurantoin-induced autoimmune hepatitis and lung fibrosis that fulfills the definitive clinical criteria for diagnosis, presenting histological, imagiological, and immunological evidence of nitrofurantoin-induced toxicity. It occurred in a 68-year-old woman with extended nitrofurantoin intake for urinary tract infection prophylaxis who presented with progressive exercise dyspnea and jaundice. Similar published cases are also reviewed in this article.

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Section: Discussionmentioning

confidence: 99%

Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease

Matos

Macedo

Mendes

et al. 2021

GE Port J Gastroenterol

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“…Steroids were used in 65% of patients either in the form of prednisone or intravenous methylprednisone. 4 , 6 , 8 – 10 , 12 , 14 , 15 , 17 – 23 , 40 – 42 Two patients did not improve after a trial of withdrawing the medication and in turn had to be put on steroids, this resulted in complete resolution of symptoms. 20 Moreover in almost all patients, clinical and biochemical improvement was noted immediately after stopping the medication.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease

Sherigar

Fazio

Zuang

et al. 2012

Clinics and Practice

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Nitrofurantoin has been in use since 1953 as an effective agent for the prevention of recurrent urinary tract infection. It is associated with a wide range of adverse drug reactions. Chronic active hepatitis has increasingly been observed and many cases have been reported with case fatalities. We present a case of nitrofurantoin induced chronic active hepatitis and briefly review the serology and clinico pathological features of 57 similar cases reported in English literature. The consistent presence of antinuclear antibody, anti smooth muscle antibody, elevated immunoglobulin and pathological feature suggests an immunologic mechanism. Complete recovery is possible in most cases if medication is discontinued in time. Steroids may play a role in management if no improvement occurs despite discontinuation of medication. We suggest all patients who are on prolonged nitrofurantoin therapy be followed up with anti nuclear antibody, anti smooth muscle antibody, serum immunoglobulin and hepatic panel every three months.

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Drug and Toxin-Induced Liver Injury

Kanel

2024

Atlas of Liver Pathology

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Nitrofurantoin-induced immune-mediated lung and liver disease

Cited by 3 publications

References 13 publications

Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease

Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease

Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease

Drug and Toxin-Induced Liver Injury

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