Nitrofurantoin and older women

Topçu, Y. İlker; Tufan, Fatih; Bahat, Gülistan; Karan, Akif

doi:10.1503/cmaj.1150069

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The development of hydantoins, the derivatives of 2,4-imidazolidinedione, for antibacterial applications has been taking place for a long time. − The mechanism of action of hydantoin derivatives is complex and not well understood, possibly due to a combination of various modes including damage to bacterial DNA, , binding to bacterial ribosomes to inhibit synthesis of critical bacterial enzymes, and so on. To date, one hydantoin derivative, nitrofurantoin, has been approved to treat urinary tract infections. − As an old antibiotic, it has recently attracted considerable interest due to its low probability of bacterial resistance compared to that of other conventional antibiotics such as fluoroquinolones, , possibly owing to the mixed mechanisms of action of hydantoins. However, hydantoin derivatives including nitrofurantoin generally exhibit only moderate antibacterial activity, which may limit their further application in combating emergent antibiotic resistance. − For instance, nitrofurantoin (Figure ) shows a minimum inhibitory concentration (MIC) of 12.5 μg/mL for methicillin-resistant Staphylococcus aureus (MRSA), and it is not active toward Pseudomonas aeruginosa up to 100 μg/mL. − …”

Section: Introductionmentioning

confidence: 99%

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

Xia

Teng

et al. 2017

J. Med. Chem.

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Hydantoin (imidazolidinedione) derivatives such as nitrofurantoin are small molecules that have aroused considerable interest recently due to their low rate of bacterial resistance. However, their moderate antimicrobial activity may hamper their application combating antibiotic resistance in the long run. Herein, we report the design of bacterial membrane-active hydantoin derivatives, from which we identified compounds that show much more potent antimicrobial activity than nitrofurantoin against a panel of clinically relevant Gram-positive and Gram-negative bacterial strains. These compounds are able to act on bacterial membranes, analogous to natural host-defense peptides. Additionally, these hydantoin compounds not only kill bacterial pathogens rapidly but also prevent the development of methicillin-resistant Staphylococcus aureus (MRSA) bacterial resistance under the tested conditions. More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.

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Section: Introductionmentioning

confidence: 99%

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

Xia

Teng

et al. 2017

J. Med. Chem.

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“…Of the 13 commentaries and reviews, there were a total of 7 commentaries and letters to the editors and 6 systematic or unstructured literature review articles. Four of the six reviews (Brodie et al, 2002;Cimolai, 2015;Guay, 2001;Sehulster & Chinn, 2003) and four of the seven commentaries (Disalvo et al, 2006;Khan & Farrag, 2000;Lefebvre et al, 2008a;Murthy et al, 2015) focused on risks associated with infection control. The remaining articles primarily discussed AAI benefits, with only a brief mention of hazard reduction.…”

Section: Commentaries and Review Articlesmentioning

confidence: 99%

Risks Associated with Animal-Assisted Intervention Programs: A Literature Review

Dalton

Waite

Ruble

et al. 2020

Preprint

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The benefits of animal-assisted interventions (AAI), to utilize companion animals as an adjunctive treatment modality, is well-established and a burgeoning research field. However, few studies have evaluated the potential hazards of these programs, such as the potential for therapy animals to transfer hospital-associated pathogens between individuals and the hospital environment. Here we review the current literature on the possible risks of hospital-based AAI programs, including zoonotic pathogen transmission. We identified twenty-nine articles encompassing reviews of infection control guidelines and epidemiological studies on zoonotic pathogen prevalence in AAI. We observed substantial heterogeneity in infection control practices among hospital AAI programs. Few data confirmed pathogen transmission between therapy animals and patients. Given AAI's known benefits, we recommend that future research utilize a One Health framework to evaluate microbial dynamics among therapy animals, patients, and hospital environments. This framework may best promote safe practices to ensure the sustainability of these valuable AAI programs.

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Nitrofurantoin and older women

Abstract: We read with interest the article by Singh and collegues suggesting that nitrofurantoin is effective for treating urinary tract infections (UTIs) in older women with lower glomerular filtration rates (GFRs).

Cited by 2 publications

References 6 publications

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

Risks Associated with Animal-Assisted Intervention Programs: A Literature Review

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