Nitrocatechols as Tractable Surface Release Systems

Wehlauch, Robin; Hoecker, Johannes; Gademann, Karl

doi:10.1002/cplu.201200251

Cited by 17 publications

(13 citation statements)

References 45 publications

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“…A mixture of 4 (Wehlauch et al . ; 220 mg, 1.16 mmol), 5 (alkyl bromide; Karimi et al . ; 757 mg, 3.35 mmol), potassium iodide (326 mg, 1.96 mmol) and potassium carbonate (421 mg, 2.73 mmol) in dry N , N ‐dimethylformamide (DMF; 5 mL) was heated at 80°C for 2 h. The reaction mixture was cooled to ambient temperature and extracted with CH 2 Cl 2 (30 mL × 3).…”

Section: Methodsmentioning

confidence: 99%

Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue

Passlick

Thapaliya

Chen

et al. 2018

The Journal of Physiology

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Photochemical release of neurotransmitters has been instrumental in the study of their underlying receptors, with acetylcholine being the exception due to its inaccessibility to photochemical protection. We caged a nicotinic acetylcholine receptor (nAChR) agonist, ABT594, via its secondary amine functionality. Effective photolysis could be carried out using either one- or two-photon excitation. Brief flashes (0.5-3.0 ms) of 410 nm light evoked large currents and Ca transients on cell bodies and dendrites of medial habenula (MHb) neurons. Unexpectedly, photorelease of ABT594 also revealed nAChR-mediated Ca signals along the axons of MHb neurons.

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Section: Methodsmentioning

confidence: 99%

Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue

Passlick

Thapaliya

Chen

et al. 2018

The Journal of Physiology

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“… Irradiation of the photolabile 2‐(2‐nitrophenyl)propyl (NPP) protecting group as TiO 2 anchor allows for the fast, light‐induced loss of such surface‐linked loading 128b…”

Section: Catecholsmentioning

confidence: 99%

Covalent Surface Modification of Oxide Surfaces

Scheres²,

et al. 2014

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The modification of surfaces by the deposition of a robust overlayer provides an excellent handle with which to tune the properties of a bulk substrate to those of interest. Such control over the surface properties becomes increasingly important with the continuing efforts at down-sizing the active components in optoelectronic devices, and the corresponding increase in the surface area/volume ratio. Relevant properties to tune include the degree to which a surface is wetted by water or oil. Analogously, for biosensing applications there is an increasing interest in so-called "romantic surfaces": surfaces that repel all biological entities, apart from one, to which it binds strongly. Such systems require both long lasting and highly specific tuning of the surface properties. This Review presents one approach to obtain robust surface modifications of the surface of oxides, namely the covalent attachment of monolayers.

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“…[43] Nitrodopamine has been used by many groups both in industry and in academia worldwide, as documented by dozens of publications [44] and patents [45] over the last five years, and is commercially available for various platforms. A further extension of the nitrodopamine linker is represented by the fourth-generation nitrocatechol, [46] which allows for underwater bonding and debonding on demand. The catecholate can be adsorbed onto metal oxide surfaces in water, and the attached cargo can then be released on demand by an outside stimulus such as a light pulse.…”

Section: Functional Synthetic Membranes By Insertion Of Biomolecules mentioning

confidence: 99%

'Active Surfaces' as Possible Functional Systems in Detection and Chemical (Bio) Reactivity

Housecroft

Palivan

Gademann

et al. 2016

Chimia

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This article presents design strategies to demonstrate approaches to generate functionalized surfaces which have the potential for application in molecular systems; sensing and chemical reactivity applications are exemplified. Some applications are proven, while others are still under active investigation. Adaptation and extension of our strategies will lead to interfacing of different type of surfaces, specific interactions at a molecular level, and possible exchange of signals/cargoes between them. Optimization of the present approaches from each of five research groups within the NCCR will be directed towards expanding the types of functional surfaces and the properties that they exhibit.

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Nitrocatechols as Tractable Surface Release Systems

Cited by 17 publications

References 45 publications

Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue

Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue

Covalent Surface Modification of Oxide Surfaces

'Active Surfaces' as Possible Functional Systems in Detection and Chemical (Bio) Reactivity

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