Nitro-Enabled Atroposelective Dynamic Kinetic Resolution of 2-Arylindoles by Phase-Transfer Catalysis
Chanhee Lee,
Sujin Lee,
Ahreum Kim
et al.
Abstract:This
study presents the atroposelective alkylation of 2-arylindoles
catalyzed by a substituted cinchonium salt as a phase-transfer catalyst.
Under the optimized reaction conditions, various substrates are employed
to yield products with high enantioselectivity. The presence of an ortho-nitro group at the aromatic ring is essential for
high atroposelectivity, because it facilitates favorable interactions
between the catalyst and substrate. The origin of the enantioselectivity
reveals favorable π–π interactions … Show more
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