Nitro azines. 21. Reactivities and electron structures of 6-nitroazolo[1,5-a]pyrimidines

Myasnikov, A. V.; Torgashev, P. A.; Pilicheva, T. L.; Русинов, В. Л.; Gromova, S. A.; Trofimova, Maria; Velik, A. V.; Чупахин, О. Н.

doi:10.1007/bf00531550

Cited by 2 publications

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“…The addition of ketones [277][278][279] gave derivatives 189, diethyl malonate [278] and dimedone [280] provide 190. Malononitrile reacted similarly as well as other active methylene nitriles leading to products 191, which were observed by spectral methods, but not isolated in individual state due to their further transformations.…”

Section: Alternative Ways Of Dihydroazolopyrymidines Formationmentioning

confidence: 99%

Dihydroazolopyrimidines: Past, Present and Perspectives in Synthesis, Green Chemistry and Drug Discovery

Desenko,

Gorobets,

Lipson

et al. 2023

The Chemical Record

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Dihydroazolopyrimidines are an important class of heterocycles that are isosteric to natural purines and are therefore of great interest primarily as drug‐like molecules. In contrast to the heteroaromatic analogs, synthetic approaches to these compounds were developed much later, and their chemical properties and biological activity have not been studied in detail until recently. In the review, different ways to build dihydroazolopyrimidine systems from different building blocks are described – via the initial formation of a partially hydrogenated pyrimidine ring or an azole ring, as well as a one‐pot assembly of azole and azine fragments. Special attention is given to modern approaches: multicomponent reactions, green chemistry, and the use of non‐classical activation methods. Information on the chemical properties of dihydroazolopyrimidines and the prospects for their use in the design of drugs of various profiles are also summarized in this review.

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