Nitriles with a Heteroatom Attached to the Cyanocarbon

A 60-times faster digital-discovery-compatible reaction setup with enhanced safety for chemical applications

“…[4][5][6][7] Modern researchers frequently face significant health risks in the laboratory setting. 8 For instance, even commonly used compounds such as methyl iodide [9][10][11][12] (LD 50 0.076 g kg −1 ), aromatic and aliphatic thiols [13][14][15][16][17] (LD 50 0.223 g kg −1 for thiophenol), aliphatic amines [18][19][20][21] (LD 50 0.373 g kg −1 for dicyclohexylamine), organic nitriles [22][23][24][25][26] (LD 50 0.410 g kg −1 for isobutyronitrile) and inorganic cyanides 8,[27][28][29][30] (LD 50 0.006 g kg −1 for KCN) possess high toxicity levels. Furthermore, several chemicals, such as benzene, 31 ethylene oxide, 32 o-toluidine, 33 trichloroethylene, 34 and vinyl chloride, 35 are known carcinogens.…”