Nitric oxide synthesis is decreased in periodontitis

Aurer, Andrej; Aleksić, Jos˘ko; Ivić-Kardum, Marija; Aurer, Jelena; Čulo, Filip

doi:10.1034/j.1600-051x.2001.028006565.x

Cited by 63 publications

(68 citation statements)

References 18 publications

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“…This result is similar to other studies that have shown increased levels of amino acids related to NO in periodontal disease (11), increased expression Table 1 Concentration of NO in saliva samples subjected to the Griess Reaction of iNOS in periodontal disease biopsy samples (25)(26)(27), as well as in gingival fibroblast cell cultures (12,28). In contrast, one report has described a reduction of salivary NO levels in individuals with adult periodontitis and with aggressive periodontitis (29). This report is in disagreement with the vast majority of the literature that describes increased levels of NO in periodontal disease (5,(30)(31)(32).…”

Section: Discussioncontrasting

confidence: 34%

Nitric oxide levels in saliva increase with severity of chronic periodontitis

et al. 2007

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The aims of this study were to compare nitric oxide (NO) levels in stimulated whole saliva from individuals with and without generalized chronic periodontitis (GCP), and to evaluate correlations between these levels with a clinical diagnostic parameter. According to specific criteria, 30 individuals were divided into three groups: one comprising individuals without periodontitis (GC), a second comprising individuals with moderate GCP (GM), and a third comprising individuals with advanced GCP (GA). Samples were collected and NO levels measured. NO in the GCP group (GM: 7.78 µM; GA: 15.79 µM) was higher than in the GC group (5.86 µM). NO levels in the GA group were significantly higher (P < 0.0001) than in the GC group, and could also differentiate (P < 0.0001) the moderate and advanced forms of the disease.

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Section: Discussioncontrasting

confidence: 34%

Nitric oxide levels in saliva increase with severity of chronic periodontitis

et al. 2007

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“…38,39 Furthermore, same studies reported that, polymorphonuclear leukocytes isolated from gingival pockets have a stronger suppressive effect on NO production than polymorphonuclear leukocytes from venous blood. However, Aurer et al 40 reported that, it is not clear whether decreased NO in periodontal disease is simply a marker of increased inflammatory activity and tissue destruction or whether it is causative in the pathogenesis of the periodontal disease.…”

Section: Inflammation;mentioning

confidence: 99%

“…During orthodontic tooth movement, remodeling which involves tissue damage and new tissue formation in the same time around the tooth alveolar bone, 40,41 periodontal ligament 42,43 and gingival tissues occur. 42 Moreover orthodontic tooth movement has similar properties with inflammation and wound healing.…”

Section: Application Of Force On Tooth;mentioning

confidence: 99%

Role of Nitric Oxide in Inflammatory Periodontal Diseases:

Çanakçı¹,

Doğan²

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Nitric oxide (NO) is a unique molecule for biological organisms, and has also very important effects on various pathologic and physiologic mechanisms. Many cell types can generate NO during different pathological and physiologic conditions. Recently, many authors have been reported the connections between NO and inflammatory diseases. Periodontal pathologies are characterized with specific periodontal inflammation and host tissues damage around the teeth, and additional factors such as force application on teeth. However, the production of NO and the role of NO in the development of periodontal pathologies are unclear. On the other hand, many evidences from previous studies indicates a close relationship between NO and periodontal pathologies. In this review, we want to discuss; overproduction of NO during inflammation and mechanical stress of force application on teeth, which directly cause progression of periodontal pathologies, and the possible effects of NO overproduction in periodontal diseases.

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“…The amount Nitrogen oxides accumulated in the dental biofilm depends on the amount of nitrate in the food consumed. Nitric oxide oxidation would be another source for nitrogen oxides production in saliva [16]. In case the plaque pH level remains low for ling time, this would lead to the accumulation of high percentage of nitrogen oxide in dental biofilm.…”

Section: Denitrification Effect On the Progression Of Periodontal Dismentioning

confidence: 99%

“…This would be the reason why nitrogen oxides are significantly higher in poor oral hygiene individuals than those with good oral hygiene who have thinner dental biofilm [22]. Many anaerobic facultative bacteria synthesize nitrate reductase in low oxygen tension [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], hence, reduction can take place in the thick biofilm or deep tongue crypts [23]. In thick cariogenic plaque, the low pH level allows the production of acidified nitrite.…”

Section: Denitrification Effect On Dental Caries Formationmentioning

confidence: 99%

The Role of Nuclear Factor Kappa B in Periodontal Diseases

Younis¹

2017

JDHODT

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Periodontal (gum) diseases are inflammatory conditions caused by microbial dental biofilm. Chronic periodontitis is the most common form of the periodontal diseases result in loss of connective tissue attachment and supporting bone that may eventually result in loss of teeth. Nuclear factor kappa B (NF-kB) is a key regulator during inflammatory process involving the gingiva and alveolar bone of teeth. In this paper, we explain the role of NF-kB in the destructive process of teeth supporting tissues.

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Nitric oxide synthesis is decreased in periodontitis

Abstract: Local NO production is decreased in patients with periodontitis. This effect is more pronounced in those with severe types of disease.

Cited by 63 publications

References 18 publications

Nitric oxide levels in saliva increase with severity of chronic periodontitis

Nitric oxide levels in saliva increase with severity of chronic periodontitis

Role of Nitric Oxide in Inflammatory Periodontal Diseases:

The Role of Nuclear Factor Kappa B in Periodontal Diseases

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