Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds

Pereira, Aline Carvalho; Paulo, Michele; Araújo, Alice V.; Rodrigues, Gerson Jhonatan; Bendhack, Lusiane Maria

doi:10.1590/s0100-879x2011007500084

Cited by 38 publications

(36 citation statements)

References 58 publications

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“…21 These cells play a fundamental role in regulation of vascular tone by synthesis and release of relaxation and contraction factors involved in cardiovascular homeostasis. 22 According to Days et al, 23 the most important endothelium-derived relaxation factors are NO, endothelium-derived hyperpolarizing factor (EDHF), and prostacyclin (PGI2). The principal contractile factors are prostaglandin H2 (PGH2), thromboxane A2, angiotensin II (Ang II), reactive oxygen species (ROS), and endothelin (ET-1).…”

Section: Endothelium and Pathophysiologic Changesmentioning

confidence: 99%

Biomarcadores de função endotelial em doenças cardiovasculares: hipertensão

Neves

Oliveira

2016

J. vasc. bras.

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The incidence of systemic arterial hypertension is increasing worldwide. The foundation of prevention is identification of people with hypertension. Nowadays, biomarkers are used to diagnose and stratify diseases and estimates prognosis. The objective of this study was to review articles published over the last 5 years on the subject of biomarkers of cardiovascular diseases. The PubMed, SciELO, Science Direct and MEDLINE databases were searched using the keywords: arterial hypertension, cardiovascular biomarkers, nitric oxide, endothelial function and asymmetric dimethylarginine. The studies reviewed show that cardiovascular diseases have complex etiologies. This article describes evidence demonstrating interactions between nitric oxide and asymmetric dimethylarginine that are involved in regulation, in metabolism, and in determination of intracellular levels, and also discusses other biomarkers related to hypertension. Some studies indicate that biomarkers are useful tools for prediction of cardiac events, whereas others state that they have little to contribute to assessments. Careful selection of tests and combinations of tests may be the key to validating use of biomarkers, in view of their low specificity for diagnosing hypertension.Keywords: biomarkers; hypertension; endothelial function; ADMA. ResumoA incidência de hipertensão arterial sistêmica está aumentando mundialmente. Sua prevenção baseia-se na identificação dos hipertensos. Atualmente, biomarcadores são utilizados com fins de diagnosticar, estratificar e prognosticar doenças. Neste estudo, objetivou-se revisar artigos dos últimos cinco anos relacionados a biomarcadores nas doenças cardiovasculares. Pesquisaram-se dados de PubMed, SciELO, Science Direct e MEDLINE, mediante as palavras-chave: hipertensão arterial, biomarcadores cardiovasculares, óxido nítrico, função endotelial e dimetilarginina assimétrica. Os estudos levantados mostram que as doenças cardiovasculares possuem uma etiologia complexa. Neste artigo, evidenciaram-se interações entre o óxido nítrico e a dimetilarginina assimétrica na regulação, no metabolismo e na determinação dos níveis intracelulares, e reviram-se outros biomarcadores relacionados à hipertensão. Alguns estudos indicam os biomarcadores como uma ferramenta útil na predição de eventos cardíacos, e outros reportam que eles contribuem pouco para a avaliação. A seleção e combinação desses pode ser uma alternativa para validar o uso dos biomarcadores devido à pouca especificidade existente para diagnosticar a hipertensão. Palavras

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Section: Endothelium and Pathophysiologic Changesmentioning

confidence: 99%

Biomarcadores de função endotelial em doenças cardiovasculares: hipertensão

Neves

Oliveira

2016

J. vasc. bras.

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“…13 In addition to L-NAME, indomethacin (IND; Nacalai Tesque), a non-selective COX inhibitor, was dissolved in sodium bicarbonate solution at the same concentrations (10, 50 and 500 mg/kg).…”

Section: Chemicalsmentioning

confidence: 99%

“…NO is synthesised from L-arginine, which is catalysed by the enzyme NO synthase (NOS). 13 Three NOS isoforms have been identified: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS). NO is continuously produced and released from the vascular endothelium via eNOS, and it regulates vascular tone against the vasoconstriction controlled by the muscle sympathetic nerve.…”

Section: Introductionmentioning

confidence: 99%

Contributions of Nitric Oxide and Prostaglandins to the Local Increase in Muscle Blood Flow following Manual Acupuncture in Rats

et al. 2015

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Objective To investigate the contributions of nitric oxide (NO) and prostaglandins (PGs) to the increase in local muscle blood flow (MBF) observed following manual acupuncture (MA). Methods Male Sprague-Dawley rats (n=112; 250-310 g) were injected intraperitoneally with a non-selective NO synthase inhibitor (NG-nitro-Larginine methyl ester hydrochloride: L-NAME; 10, 50 or 500 mg/kg), a non-selective cyclooxygenase inhibitor (indomethacin; 10, 50 or 500 mg/kg), a combination of L-NAME and indomethacin (500 mg/kg each) or saline only under urethane anaesthesia (1.2 g/kg). We used the sparrow pecking technique for 1 min with a stainless steel acupuncture needle (0.20×30 mm) as the acupuncture stimulation method. The stimulus point was on the right tibialis anterior muscle. 51Chromium-labelled microspheres were used for MBF measurement. Results MA increased MBF in the saline-injected group ( p<0.001). This increase was partially inhibited by L-NAME in a dose-dependent manner ( p>0.05, p<0.05 and p<0.001 for 10, 50 and 500 mg/kg, respectively). On the other hand, indomethacin did not suppress the increase ( p>0.05 each for 10, 50 and 500 mg/kg). No significant difference was observed between the inhibitory effects of combined administration of L-NAME and indomethacin and single administration of L-NAME ( p>0.05). Conclusions These results suggest that NO is a major factor in the MA-induced increase in MBF, while PGs do not contribute significantly to this increase. As complete inhibition was not achieved by administration of L-NAME±indomethacin, it appears that non-NO and non-PG vasodilators are additionally involved. BACKGROUNDAcupuncture induces analgesia and functional improvement in various types of

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“…The radioprotective potential of L-arginine relates to the synthesis of nitric oxide, arising from the oxidation of one of its guanidine nitrogens 3 . Nitric oxide is a potent mediator, with diverse roles in regulating cellular functions and signaling pathways 4 .…”

Section: Introductionmentioning

confidence: 99%

Nutritional supplementation with arginine protects radiation-induced effects. An experimental study

et al. 2016

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PURPOSE:To investigate the protective effect of L-arginine on the prostate (nonneoplasic) of rats with radiation-induced injury. METHODS:Twenty-nine Wistar rats, male adult, allocated into three groups: Control group (C) was not exposed to irradiation (n=10); Radiated group (R) had undergone pelvic irradiation (n=10); Supplemented and radiated group (R+S) had undergone pelvic irradiation plus L-arginine supplementation (n=9). The animals were observed for signs of toxicity. After euthanization, the prostate was dissected under magnification and stained by hematoxylin and eosin to study acinar structures and stained with Picrosirius red for collagen analysis. RESULTS:After radiation exposure, all animals presented diarrhea, but supplementation with L-arginine reduced this effect. The weight gain in the R+S group was significantly higher than in the C and R groups. In the R+S group the collagen density and the prostate acinar area was similar to the R and C groups. Epithelial height was significantly reduced in group R compared with group C (p<0.0001). When comparing the group R+S with R, a statistical difference was observed to be present (p<0.0001). CONCLUSIONS:Pelvic radiation promotes systemic effects and some structural modifications in the ventral prostate of rats. These modifications can be prevented by oral supplementation with L-arginine.

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Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds

Cited by 38 publications

References 58 publications

Biomarcadores de função endotelial em doenças cardiovasculares: hipertensão

Biomarcadores de função endotelial em doenças cardiovasculares: hipertensão

Contributions of Nitric Oxide and Prostaglandins to the Local Increase in Muscle Blood Flow following Manual Acupuncture in Rats

Nutritional supplementation with arginine protects radiation-induced effects. An experimental study

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