Nitric oxide synthase inhibition in migraine

Lassen, LH; Ashina, Messoud; Christiansen, I; Ulrich, Vibeke; Olesen, Jes

doi:10.1016/s0140-6736(97)80021-9

Cited by 232 publications

(151 citation statements)

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“…Chen et al [18] reported that the rate of smoking was higher in women with migraine than in women without migraine. The theory that the frequency of migraine can increase due to decreased nitric oxide synthesis in smokers has been focused on [19]. In our study, it was found that the prevalence of migraine was higher in smoking asthma patients and that smoking was not only a trigger but also a risk factor for migraine.…”

Section: Discussionmentioning

confidence: 60%

Presence of Headache and Migraine in Asthma Patients

Turan¹,

Susuz²,

Turan³

2017

Turk Thorac J

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OBJECTIVES:Migraine is a diseases characterized with severe headaches, with neurological and systemic findings. The purpose of this study is to investigate the prevalence of migraine and to examine whether there is a relationship between atopic disorders, parental history and migraine in asthma patients. MATERIAL AND METHODS:A total of 288 asthma outpatients, who had the diagnosis by an early or late test of reversibility showing a reversible airway obstruction according to hospital database were included. The presence of headache, atopic symptoms and parental history about asthma, atopic disorders and migraine were asked. The patients with headache were consultated by neurology department and investigated about the presence of migraine. The diagnosis of migraine headache was made if patients fulfilled the International Headache Society (IHS) criteria. RESULTS:60.4% of patients described a headache. There were 94 patients (32.6%) with headaches meeting the IHS criteria for migraine. Only 12 patients had migraine with aura. There were atopic symptoms in 86.8% of patients. According to parental history, there were asthma in 47.9%, atopic symptoms in 39.6% and migraine in 22.2% of parents. Patients with atopic symptoms were found to have significantly high rate of headaches (65.3%) "p=0.007". The prevalence of migraine was significantly high in patients with parental atopic symptoms (54%) "p=0.002". Multiple logistic regression analysis identified that gender, parental history of asthma, allergia and migraine, and smoking were independent risk factors for presence of migraine in asthmatics. CONCLUSION:There is a high prevalence of migraine headaches in patients with asthma. The coexistence of asthma and headaches may be related with a similar pathophysiological mechanism; parental history, common genetic compounds and smoking may play role in this mechanism. The headaches in asthma patients, atopic symptoms and family history should be questioned, and clinicians should be careful about the presence of migraine.

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Section: Discussionmentioning

confidence: 60%

Presence of Headache and Migraine in Asthma Patients

Turan¹,

Susuz²,

Turan³

2017

Turk Thorac J

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“…It cannot therefore be excluded that both neural and endothelial mechanisms could be influenced in the analgesic effect of NOS inhibition in migraine. The effect of the drug in these patients seems not to be mediated by vasocontriction of cerebral vessels because the flow velocities in the middle cerebral arteries measured by transcranial Doppler were not affected [66].…”

Section: Nitric Oxide Synthase Inhibitionmentioning

confidence: 79%

“…A recent double-blind controlled study [66,67] showed that L-NMMA infusion induced a significant improvement of migraine pain and accompanying symptoms such as phonophobia and photophobia within 30 minutes. This positive effect was observed in 66% of the patients treated with the drug versus a placebo effect of 14%.…”

Section: Nitric Oxide Synthase Inhibitionmentioning

confidence: 99%

Nitric oxide in primary headaches

Gallai¹,

Sarchielli²

2000

J Headache Pain

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Nitric oxide (NO) has been proposed to be a key molecule in migraine. Experimental evidence suggests its intervention in vasodilatation and activation of the trigeminovascular system as well as its involvement in the supraspinal pathways implicated in head pain processing. Other findings suggest the implication of NO in coupling neuronal and vascular changes during spreading depression. A potential role for NO has also been proposed in the pathophysiological mechanisms underlying cluster headache and chronic tension-type headache. The most relevant evidence for an increased response to exogenous NO in all primary headaches emerges from the experimental model of nitroglycerin-induced headache. Moreover, the effectiveness of non-selective NO synthase inhibitor L-N-monomethylarginine (L-NMMA) further supports the involvement of NO in migraine and chronic tension-type headache. The endogenous increase in NO production has been shown only in studies carried out during spontaneous migraine attacks which demonstrated increased levels of nitrites and cGMP in peripheral blood and internal jugular blood; the latter was followed by an increased production of algogenic and vasodilatatory prostanoids. These data suggest the potential activation of cyclooxygenase (COX) due to NO. Additional evidence suggests the increased activity of L-arginine/NO pathway in the platelet model in migraine patients. This increase was also evident between attacks, more accentuated during attacks and expressed to a greater extent during late luteal phase in menstrual migraine. Higher NO production in platelet was also demonstrated in patients affected by chronic daily headache and they are accompanied by significant lower serotonin content and higher levels of intracellular calcium. Whether these changes may be expressed in the central nervous system is a matter of discussion. These data taken together suggest a crucial role played by NO in neurovascular headaches and chronic headaches. Further research concerning NO in all primary headaches will be aimed at verifying changes of reliable markers of NO metabolism and NO effects, to better understand the complex COX/NO synthase (NOS) interactions, to investigate the effectiveness of selective NOS inhibitors in discriminating neural versus vascular involvement of NO.

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“…In Sudan, Alawad et al found complete CW in 72% while in the present study a complete CW observed in 32% of the control group versus 84% of migraineurs [24]. Nitrates trigger while nitric oxide synthase inhibition abort migraine attacks [25][26][27]. Upon exposure to induced ischemia, endothelial nitric oxide synthase (eNOS) knockout mice develop larger infarcts attributable partly to defective vasodilatation and decreased collateral blood flow.…”

Section: Discussionmentioning

confidence: 61%

Abnormal Circle of Willis among Migraineurs in Sudan

Ibrahim¹

2017

JNSK

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Background: Several studies have shown a strong relationship between migraine and cerebral ischemia. The circle of Willis (CW) which is the main cerebral collateral pathway that allows flow redistribution in response to low perfusion is reported to be defective in migraine.Objectives: This study aims to assess the structural characteristics of circle of willis (CW) in Sudanese migraineursMethods: This is a descriptive study including 46 migraineurs selected from a larger study (Migraine Profile in Sudan; a genetic, EEG and MRI study in 12 Sudanese pedigrees) and 100 apparently circle. Volunteers. All subjects underwent threedimensional MRA of the cerebral arterial Results: Defective Circle of Willis is observed in 5 % (n= 40) of migraineurs versus 68 % (n=68) of control. Fifty nine point six percent of migraineurs (n=28) and 53%(n=53) of control showed in complete configuration of CW. Hypoplastic vessels account for 46.8 % (n=22) in migraineurs especially in posterior circulation with 19 % (n=9) have hypoplastic both PcoA (P value 0.0001). While hypoplasia of either left or right but not both posterior communicating vessels was observed in 9% (n=9) of control Furthermore, frequent migraine attacks is significantly associated with hypoplastic arteries of the posterior circulation (P value 0.002). Conclusions:Strong association observed between migraine and an abnormal configuration of the circle of Willis with hypoplasia of the both posterior communicating arteries significantly associated with frequent migraine attacks. This finding needs further confirmation as it will have an impact on the management and prognosis

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Nitric oxide synthase inhibition in migraine

Cited by 232 publications

References 5 publications

Presence of Headache and Migraine in Asthma Patients

Presence of Headache and Migraine in Asthma Patients

Nitric oxide in primary headaches

Abnormal Circle of Willis among Migraineurs in Sudan

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