Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia

Yoo, Koo Han; Kim, Su Kang; Chung, Joo-Ho; Chang, Sung‐Goo

doi:10.1038/aja.2010.37

Cited by 11 publications

(13 citation statements)

References 31 publications

(32 reference statements)

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“…The aim of the present study was to investigate whether four single nucleotide polymorphisms (SNPs) (rs4986938, rs17766755, rs12435857 and rs1256049) of the ESR2 gene were associated with the development of BPH. Based on their symptoms, the subjects were allocated to either the control (prostate volume, <30 ml) or the BPH [prostate volume, ≥30 ml; IPSS, >8; Qmax, <15 ml/sec] group (11,12). The demographic characteristics of the BPH and control groups are shown in Table I.…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia

Kim

Chung

Park

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Estrogens and estrogen receptors (ESRs) have been implicated in the stimulation of aberrant prostate growth and the development of prostate diseases. The aim of the present study was to investigate four single nucleotide polymorphisms (SNPs) of the ESR2 gene in order to examine whether ESR2 is a susceptibility gene for benign prostatic hyperplasia (BPH). In order to evaluate whether an association exists between ESR2 and BPH risk, four polymorphisms [rs4986938 (intron), rs17766755 (intron), rs12435857 (intron) and rs1256049 (Val328Val)] of the ESR2 gene were genotyped by direct sequencing. A total of 94 patients with BPH and 79 control subjects were examined. SNPStats and Haploview version 4.2 we used for the genetic analysis. Multiple logistic regression models (codominant1, codominant2, dominant, recessive and log-additive) were produced in order to obtain the odds ratio, 95% confidence interval and P-value. Three SNPs (rs4986938, rs17766755 and rs12435857) showed significant associations with BPH (rs4986938, P=0.015 in log-additive model; rs17766755, P=0.033 in codominant1 model, P=0.019 in dominant model and P=0.020 in log-additive model; rs12435857, P=0.023 in dominant model and P=0.011 in log-additive model). The minor alleles of these SNPs increased the risk of BPH, and the AAC haplotype showed significant association with BPH (χ 2 =6.34, P=0.0118). These data suggest that the ESR2 gene may be associated with susceptibility to BPH.

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Section: Introductionmentioning

confidence: 99%

Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia

Kim

Chung

Park

et al. 2015

Experimental and Therapeutic Medicine

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“…These results suggest that ETS-1 represses the expression of the immunity-related genes CD38 and HDAC9, while activating the expression of BCL11A, CRISP3, DMBT1, FGR, NOS2 and SAA1 in PC3 PCa cells. Besides the roles of these genes in the immune response, several have been reported to be involved in various types of cancer, including PCa (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). However, the precise roles that these genes may play in the network of cellular and molecular mechanisms of antitumor immunology according to current models is not always clear from the literature.…”

Section: Discussionmentioning

confidence: 70%

“…FGR has been suggested to play a significant role in ovarian carcinoma cancer growth (25). NOS2 has been reported to be implicated and correlated with various prostatic diseases including PCa (26). Finally, SAA1 has been found to be highly expressed in lung cancer tissue (27) and over-expressed in ovarian carcinoma tissues (28).…”

Section: Discussionmentioning

confidence: 99%

Regulation of prostate cancer immunity-related genes in PC3 prostate cancer cells by ETS-1

Shaikhibrahim¹,

Lindstrot²,

Buettner³

et al. 2011

Oncology Letters

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Abstract. Prostate cancer (PCa) is one of the most prevalent forms of cancer affecting males worldwide, and knowledge of the immune defenses involved in PCa remains incomplete. Since the identification of immunity-related genes may have enormous implications for the understanding of PCa immunology, we recently reported the identification of immunity-related genes in PCa tissues and found potential binding sites for the ETS family prototype, ETS-1, in the majority of genes identified. Therefore, as a continuation of our previous study, we investigated whether ETS-1 regulates these genes in an in vitro PCa cell line model, PC3 cells. We specifically blocked ETS-1 in PC3 cells by transfection with an ETS-1 inverse antisense expression vector or a mock control vector. We then assessed the effect of the blockade on the expression of the recently identified PCa immunity-related genes using a comprehensive oligo gene expression microarray analysis. The results showed that ETS-1 is involved in the activation or repression of the recently identified immunity-related genes in PCa. These findings provide insights into the regulation of immunity-related genes in PCa, and emphasize the importance of ETS-1 in prostate cancer immunology.

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“…Benign prostatic hyperplasia (BPH) is a pathological change that causes lower urinary tract symptoms and is one of the most common urologic diseases in older men (Yoo et al, 2010;Huh et al, 2013). Studies from western countries have reported that the prevalence of BPH is 40-50% by age 50 years and nearly 80% by age 70 years (Burnett and Wein, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Some research has shown that inflammatory cytokines, such as interleukin (IL)-2, IL-7, and interferon-γ, are overexpressed in BPH tissue (Kramer et al, 2002). Furthermore, recent studies have shown that nitric oxide synthase 2, IL-10, and IL-10RB gene polymorphisms are associated with BPH (Yoo et al, 2010(Yoo et al, , 2011. Lymphotoxin (LT), which was first identified in 1968, is a cytotoxic molecule produced by lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population

Lee

Yoo

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 (Ala172Ala)] located in the promoter and coding regions of LTβR using direct sequencing. The genotype distributions of rs3759334 were associated with prostate volume larger than 40 g. There were significant differences between the small (<40 g) and large (≥40 g) group subjects [codominant 1 model: odds ratio (OR) = 4.65, 95% confidence interval (CI) = 1.95-11.09, P = 0.001; dominant model: OR = 4.91, 95%CI = 2.07-11.63, P = 0.0002; log-additive model: OR = 4.81, 95%CI = 2.05-11.24, P = 0.0001]. The allele distributions of rs3759334 were significantly associated with BPH (OR = 4.87, 95%CI = 2.16-10.99, P = 0.0001). The distribution of rs2364480 was significantly different between groups (codominant 1 model: OR = 2.17, 95%CI = 1.11-4.26, P = 0.028; dominant model: OR = 2.16, 95%CI = 1.13-4.12, P = 0.019; log-additive model: OR = 1.86, 95%CI = 1.07-3.24, P = 0.027). The allele distribution of rs2364480 was significantly associated with BPH (OR = 1.88, 95%CI = 1.08-3.30, P = 0.027). We found that LTβR polymorphisms caused severe BPH. Thus, LTβR may contribute to the risk of BPH development.

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Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia

Cited by 11 publications

References 31 publications

Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia

Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia

Regulation of prostate cancer immunity-related genes in PC3 prostate cancer cells by ETS-1

Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population

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