Nitric oxide regulation of lymphocyte function

Hoffman, Rosemary A.; Ford, Henri R.

doi:10.1007/978-3-0348-8241-5_8

Cited by 1 publication

(1 citation statement)

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“…Another aspect worthy of consideration is the role of NO on immune cell function in acute cardiac rejection. In this context, NO is known to have significant immunosuppressive activity to down-regulate T-lymphocyte proliferation as well as downregulate T-lymphocyte activation [131][132][133][134][135][136][137][138]. This action potentially confounds the general understanding of the totality of the role of NO derived from iNOS on acute cardiac allograft rejection.…”

Section: No Actions On Inflammatory Cells In Acute Cardiac Rejectionmentioning

confidence: 99%

The complex role of iNOS in acutely rejecting cardiac transplants

Pieper

Roza

2008

Free Radical Biology and Medicine

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This review summarizes the evidence for a detrimental role of nitric oxide (NO) derived from inducible NO synthase (iNOS) and/or reactive nitrogen species such as peroxynitrite in acutelyrejecting cardiac transplants. In chronic cardiac transplant rejection, iNOS may have an opposing beneficial component. The purpose of this review is primarily to address issues related to acute rejection which is a recognized risk factor for chronic rejection. The evidence for a detrimental role is based upon strategies involving non-selective NOS inhibitors, NO neutralizers, selective iNOS inhibitors and iNOS gene deletion in rodent models of cardiac rejection. The review is discussed in the context of the impact on various components including graft survival, histological rejection and cardiac function which may contribute in toto to the process of graft rejection. Possible limitations of each strategy are discussed in order to understand better the variance in published findings including issues related to the potential importance of cell localization of iNOS expression. Finally, the concept of a dual role of NO and its down-stream product, peroxynitrite, in rejection vs. immune regulation is discussed.

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