Nitric oxide regulates nucleoside transport in activated B lymphocytes

Soler, Concepció; Felipe, Antônio; Casado, F. Javier; Pastor‐Anglada, Marçal

doi:10.1002/jlb.67.3.345

Cited by 28 publications

(37 citation statements)

References 30 publications

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“…CNT2 mRNA and protein levels were increased right before the peak of incorporation of thymidine into DNA and during liver regeneration after partial hepatectomy [70,71] . CNT2 expression was up-regulated by lipopolysaccharide (LPS), NO, INF-a and TNF-a in macrophages and B-lymphocytes in several studies [72][73][74] . The LPS-induced increase of adenosine transport and molecular expression is TNF-a-dependent but not iNOs-dependent.…”

Section: Regulation Of Adenosine Transport and Cnt2 Expression In Genmentioning

confidence: 99%

Adenosine: An immune modulator of inflammatory bowel diseases

Ye¹,

Rajendran²

2009

WJG

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Inflammatory bowel disease (IBD) is a common and lifelong disabling gastrointestinal disease. Emerging treatments are being developed to target inflammatory cytokines which initiate and perpetuate the immune response. Adenosine is an important modulator of inflammation and its anti-inflammatory effects have been well established in humans as well as in animal models. High extracellular adenosine suppresses and resolves chronic inflammation in IBD models. High extracellular adenosine levels could be achieved by enhanced adenosine absorption and increased de novo synthesis. Increased adenosine concentration leads to activation of the A2a receptor on the cell surface of immune and epithelial cells that would be a potential therapeutic target for chronic intestinal inflammation.Adenosine is transported via concentrative nucleoside transporter and equilibrative nucleoside transporter transporters that are localized in apical and basolateral membranes of intestinal epithelial cells, respectively. Increased extracellular adenosine levels activate the A2a receptor, which would reduce cytokines responsible for chronic inflammation.

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Section: Regulation Of Adenosine Transport and Cnt2 Expression In Genmentioning

confidence: 99%

Adenosine: An immune modulator of inflammatory bowel diseases

Ye¹,

Rajendran²

2009

WJG

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“…Lipopolysaccharides and phorbol esters, which activate B cells, upregulate CNTs and downregulate ENTs in lymphocytes from the bone marrow and in a human B lymphoblast cell line (Soler et al, 1998;Soler et al, 2000;Soler et al, 2001a, b). These effects were shown to result from differential regulation of NTs by agents like protein kinase C (PKC) and tumor necrosis factor-a.…”

Section: Regulation Of Ntsmentioning

confidence: 99%

“…These effects were shown to result from differential regulation of NTs by agents like protein kinase C (PKC) and tumor necrosis factor-a. Nitric oxide may also be involved in the regulation of NTs in activated human B lymphocytes (Soler et al, 2000). Acute stimulation of d and e isoforms of PKC resulted in an increase in transport activity in cultured MCF-7 breast cancer cells and HeLa cells, whereas downregulation resulted in a decrease in transport activity .…”

Section: Regulation Of Ntsmentioning

confidence: 99%

Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

et al. 2003

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The clinical efficacy of anticancer nucleoside drugs depends on a complex interplay of transporters mediating entry of nucleoside drugs into cells, efflux mechanisms that remove drugs from intracellular compartments and cellular metabolism to active metabolites. Nucleoside transporters (NTs) are important determinants for salvage of preformed nucleosides and mediated uptake of antimetabolite nucleoside drugs into target cells. The focus of this review is the two families of human nucleoside transporters (hENTs, hCNTs) and their role in transport of cytotoxic chemotherapeutic nucleoside drugs. Resistance to anticancer nucleoside drugs is a major clinical problem in which NTs have been implicated. Single nucleotide polymorphisms (SNPs) in drug transporters may contribute to interindividual variation in response to nucleoside drugs. In this review, we give an overview of the functional and molecular characteristics of human NTs and their potential role in resistance to nucleoside drugs and discuss the potential use of genetic polymorphism analyses for NTs to address drug resistance.

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“…In this group, the 4-, 8-position tertiary amine was replaced by a secondary amine to explore the SAR effects of the resulting free hydrogen (Figure 4.5). Substitutions ranged from monoalkyl (128)(129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139)(140)(141)(142)(143)(144)(145)(146), cycloalkyl (147)(148)(149)(150)(151)(152)(153), to aromatic rings (154)(155)(156)(157). These compounds showed a wide range of activities from 12 -100 % inhibition of colony formation.…”

Section: Resultsmentioning

confidence: 99%

“…The regulatory response of es has been shown to require nitric oxide (NO) in B lymphocytes (138). Nerve growth factor stimulates adenosine transport in cultured bovine chromaffin cells (139).…”

Section: Regulation Of Nucleoside Transporter Expression and Consequementioning

confidence: 99%

Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues

Grant

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Nitric oxide regulates nucleoside transport in activated B lymphocytes

Cited by 28 publications

References 30 publications

Adenosine: An immune modulator of inflammatory bowel diseases

Adenosine: An immune modulator of inflammatory bowel diseases

Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues

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