Nitric oxide regulates interactions of PMN with human brain microvessel endothelial cells

Wong, Donald; Prameya, Rukmini; Dorovini-Zis, Katerina; Vincent, Steven R.

doi:10.1016/j.bbrc.2004.08.062

Cited by 22 publications

(17 citation statements)

References 35 publications

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“…Our previous [22] and present studies have clearly shown that chemically distinct NO-releasing compounds impair the respiratory burst, adhesive activity and expression of CD11b/CD18 molecule on human neutrophils submitted to activation with pro-infl ammatory agents such as PMA or fMLP. Other studies have also demonstrated that NO donors decrease other functions of neutrophil such as: chemotaxis, degranulation, adherence and ROS production [5,[25][26][27]. The signalling events, which are responsible for NO donor's effects on neutrophil functional response, are not fully clarifi ed.…”

Section: Discussionmentioning

confidence: 99%

Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitro

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitro

et al. 2007

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“…NO is also correlated to MPO in oxygen metabolites release in the inflammation site (Lakshmi et al, 2005). Furthermore, NO also modulates neutrophils in vitro by influencing the expression of the adhesion molecules endothelial selectin type E (E-selectin) and intercellular adhesion molecule type 1 (ICAM-1) (Wong et al, 2004). In this context, we analyzed the effect of Passiflora edulis extract on the MPO and NO levels in the pleurisy induced by Cg.…”

Section: Effect Of Passiflora Edulis Upon Myeloperoxidase and Nitric mentioning

confidence: 99%

Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model

Montanher

Zucolotto

Schenkel

et al. 2007

Journal of Ethnopharmacology

129

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“…SNP, SIN-1 and DEA/NO decreased the PMA-or fMLP-stimulated adhesion in a dose-dependent manner (data not shown). Others also reported that chemically distinct NO donors reduced the adhesion of human neutrophils [48,49]. The mechanism by which NO donors affect the neutrophil adhesion is not fully clear.…”

Section: Adhesive Activity Of Activated Neutrophils In the Presence Omentioning

confidence: 93%

“…The mechanism by which NO donors affect the neutrophil adhesion is not fully clear. It was proposed that NO donors regulate the expression of adhesion molecules on cells through the interaction with transcription factor NF-κB [48,49]. It is suggested that NO donors can prevent neutrophil adhesion by affecting adhesive properties of cell directly.…”

Section: Adhesive Activity Of Activated Neutrophils In the Presence Omentioning

confidence: 99%

Effects of Nitric Oxide Donors on the Biological Activity of Human Neutrophils in Vitro. Review Own Studies

Klink¹,

Sułowska

2007

LDDD

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This review summarizes our investigations on the reactivity of human polymorphonuclear neutrophils treated with the pharmacologically active compounds that liberate nitric oxide in vitro. The results of our study show that nitric oxide liberation from sodium nitroprusside (SNP), 3-morpholinosydnonimine (SIN-1) and Diethylamine/NO is a time-and dose-dependent and the kinetics of NO production is different between the three compounds. The effect of exogenously administered compounds on the neutrophil functional state depends on the compounds concentration, rate and mechanism of NO liberation, treatment time of neutrophils and on the stimulus employed to cells activation. SNP and DEA/NO actions on neutrophil respiratory burst are mainly associated with modulation of PKC and MEK1/2 activities, while SIN-1 with PKTs activities. The course of neutrophil apoptosis in vitro shows that different compounds depending on the mechanisms of NO release exert differential effects on apoptotic events. SNP and SIN-1 are involved in the process of bacterial killing by neutrophils. We conclude that NO released and its derivatives formed in the course of the interaction between neutrophils and bacteria are responsible for the enhancement of neutrophil antibacterial activity.

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Nitric oxide regulates interactions of PMN with human brain microvessel endothelial cells

Cited by 22 publications

References 35 publications

Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitro

Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitro

Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model

Effects of Nitric Oxide Donors on the Biological Activity of Human Neutrophils in Vitro. Review Own Studies

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