Nitric oxide production and blood corpuscle dynamics in response to the endocrine status of female rats

Uematsu, Kazuhiko; Katayama, Tohru; Katayama, Hirokazu; Hiratsuka, Mie; Kiyomura, Masaki; M, Ito

doi:10.1016/j.thromres.2010.09.013

Cited by 3 publications

(4 citation statements)

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“…Estrogen deficiency in OVX animals and menopausal woman may affect platelet reactivity and thrombosis. Reduced estrogen in OVX Wistar rats causes a decrease in NO production in venules, resulting in thrombus formation, and estrogen treatment restores NO production and endothelium relaxation by increasing platelet velocity and decreasing platelet adhesion [6]. Estrogen replacement in OVX rats induces vascular enzyme ADPase activity, thereby eliminating the ADP platelet activator [11].…”

Section: Discussionmentioning

confidence: 99%

“…Platelets from hypercholesterolemic patients were more reactive to aggregating reagents such as epinephrine and adenosine diphosphate (ADP) than platelets from normal individuals [9], and ex vivo platelets from hypercholesterolemic patients showed hyperactivity and shortened platelet survival [10]. Estrogen deficiency in OVX animals and menopausal woman can cause an increased platelet aggregation and thrombosis by affecting platelet agonist hydrolysis [11] and blood vessel nitric oxide production [6]. Hormonal changes in menopausal woman may affect electrolyte disturbance, water retention and blood pressure.…”

Section: Introductionmentioning

confidence: 99%

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Effects of green tea orSasa quelpaertensisbamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats

et al. 2012

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This study was conducted to investigate the effects of Sasa quelpaertensis bamboo and green tea on plasma and liver lipids, platelet aggregation, and erythrocyte membrane Na channels in ovariectomized (OVX) rats. Thirty female rats were OVX, and ten female rats were sham-operated at the age of 6 weeks. The rats were divided into four groups at the age of 10 weeks and fed the experiment diets: sham-control, OVX-control, OVX-bamboo leaves (10%), or OVX-green tea leaves (10%) for four weeks. Final body weight increased significantly in the OVX groups compared with that in the sham-control, whereas body weight in the OVX-green tea group decreased significantly compared with that in the OVX-control (P < 0.01). High density lipoprotein (HDL)-cholesterol level decreased in all OVX groups compared with that in the sham-control rats (P < 0.05) but without a difference in plasma total cholesterol. Plasma triglycerides in the OVX-green tea group were significantly lower than those in the sham-control or OVX-control group (P < 0.05). Liver triglycerides increased significantly in the OVX-control compared with those in the sham-control (P < 0.01) but decreased significantly in the OVX-green tea group compared with those in the OVX-control or OVX-bamboo group (P < 0.01). Platelet aggregation in both maximum and initial slope tended to be lower in all OVX rats compared with that in the sham-control rats but was not significantly different. Na-K ATPase tended to increase and Na-K cotransport tended to decrease following ovariectomy. Na-K ATPase decreased significantly in the OVX-green tea group compared with that in the OVX-control group (P < 0.01), and Na-K cotransport increased significantly in the OVX-bamboo and OVX-green tea groups compared with that in the OVX-control (P < 0.05). Femoral bone mineral density tended to be lower in OVX rats than that in the sham-control, whereas the green tea and bamboo leaves groups recovered bone density to some extent. The results show that ovariectomy caused an increase in body weight and liver triglycerides, and that green tea was effective for lowering body weight and triglycerides in OVX rats. Ovariectomy induced an increase in Na efflux via Na-K ATPase and a decrease in Na efflux via Na-K cotransport. Furthermore, consumption of green tea and bamboo leaves affected Na efflux channels, controlling electrolyte and body water balance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of green tea orSasa quelpaertensisbamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats

et al. 2012

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“…Estrogen increases the production of nitric oxide, which mediates the opening of K ATP channels [12,13]. Calcium overload also plays an important role in ischemicreperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

“…Estrogen-induced antiarrhythmia may be related to the opening of K ATP channels and estrogen-induced release of nitric oxide, which was also linked to the activity of K ATP channels [12,13]. It has also been reported that 17b-estradiol increased the levels of SUR2A mRNA, the regulatory subunit of the K ATP channel, in heart-derived H9c2 cells [14].…”

Section: Introductionmentioning

confidence: 97%

Neuroprotective effects of 17β-estradiol associate with KATP in rat brain

Zhang

Xia

et al. 2012

NeuroReport

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Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates K(ATP) channel activity; the present study was designed to address the involvement of K(ATP) channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, K(ATP) mRNA and protein in the cortices of rats were compared among groups of ovariectomized rats (Ovx-1), Sham-operated rats (Sham-1), and ovariectomized rats administered 17β-estradiol (Estr-1). In experiment 2, neurobehavioral scores and infarct volume of rats were evaluated after middle cerebral artery occlusion in ovariectomized rats (Ovx-2), Sham-operated rats (Sham-2), ovariectomized female rats administered 17β-estradiol (Estr-2), and ovariectomized rats administered both 17β-estradiol and stereotactic injections of glibenclamide (Estr+G). Our results showed that the Kir6.2 and SUR1 mRNA and protein levels in the brain cortices of female ovariectomized rats were lower than those in Sham rats. However, the expression levels of Kir6.2 and SUR1 in brain cortices of ovariectomized rats recovered after supplementation with 17β-estradiol. The protective effects of 17β-estradiol were abolished by glibenclamide, a K(ATP) channel blocker. This indicates that estradiol significantly upregulates the expression of K(ATP) channel subunits and channel activity in the brain cortices of ovariectomized rats. This regulation is associated with the neuroprotective effects of estradiol.

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