2000
DOI: 10.1016/s0162-3109(00)00220-4
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Nitric oxide, peroxynitrite, and lower respiratory tract inflammation

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Cited by 23 publications
(21 citation statements)
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“…26 The main site of inducible (type II) NO synthase expression is the airway epithelium, and it is also observed in several inflammatory cells. 27 It is therefore conceivable that epithelial cells of small airways and inflammatory cells infiltrating peripheral airways wall contribute to the levels of NO measured in expired air. Chronic inflammation can be associated with modified structure of the small airway walls, which contributes to the nonhomogeneous obstruction of small airways.…”
Section: Discussionmentioning
confidence: 99%
“…26 The main site of inducible (type II) NO synthase expression is the airway epithelium, and it is also observed in several inflammatory cells. 27 It is therefore conceivable that epithelial cells of small airways and inflammatory cells infiltrating peripheral airways wall contribute to the levels of NO measured in expired air. Chronic inflammation can be associated with modified structure of the small airway walls, which contributes to the nonhomogeneous obstruction of small airways.…”
Section: Discussionmentioning
confidence: 99%
“…One marker of inflammation has been measurement of NO, a gas produced by lung epithelial cells, which has been shown to be elevated in several inflammatory airway conditions (6). We hypothesized that doxycycline possesses potent anti-inflammatory properties in murine lung epithelial cells, leading to a reduction of NO produced by inducible NO synthase (iNOS) 3 and that this inhibition is due, at least in part, to decreased stabilization and expression of iNOS mRNA and its translation to form active iNOS enzyme.…”
mentioning
confidence: 99%
“…This nitrosative stress can thus alter protein function. 84 Production of NOx therefore increases during inflammation and oxidative stress, but can vary depending on pulmonary damage, medication 85 and smoking status. 86 Even though the data in the literature are contradictory, the simplicity of Griess colorimetry assay combined with its low cost favors analysis of these biomarkers.…”
Section: Nitrogen Oxidesmentioning
confidence: 99%