Nitric oxide/paclitaxel micelles enhance anti-liver cancer effects and paclitaxel sensitivity by inducing ferroptosis, endoplasmic reticulum stress and pyroptosis

Li, Huilan; Deng, Xiaoyu; Zhang, Ziwei; Yang, Zunhua; Huang, Hesong; Ye, Xide; Zhong, Linyun; Xu, Guoliang; Liu, Ronghua; Fang, Yuanying

doi:10.1039/d3ra04861f

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Research[ 24 ] proved that erastin regulates lncRNAGABPB1-AS1, and the latter down-regulates GABPB1 protein level by blocking GABPB1 translation, leading to downregulation of PRDX5 gene, and ultimately inhibits the antioxidant capacity of cells. ROS and MDA accumulation and HepG2 cell death were induced[ 87 ]. The study also found that high expression levels of GABPB1 were associated with poor prognosis in HCC patients, while high levels of GABPB1-AS1 in liver cancer patients were associated with improved overall survival.…”

Section: Regulatory Factors Involved In Ferroptosis Of Liver Cancermentioning

confidence: 99%

Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer

Shu,

Lao,

Qiu

2024

World J Gastrointest Oncol

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As a highly aggressive tumor, the pathophysiological mechanism of primary liver cancer has attracted much attention. In recent years, factors such as ferroptosis regulation, lipid peroxidation and metabolic abnormalities have emerged in the study of liver cancer, providing a new perspective for understanding the development of liver cancer. Ferroptosis regulation, lipid peroxidation and metabolic abnormalities play important roles in the occurrence and development of liver cancer. The regulation of ferroptosis is involved in apoptosis and necrosis, affecting cell survival and death. Lipid peroxidation promotes oxidative damage and promotes the invasion of liver cancer cells. Metabolic abnormalities, especially the disorders of glucose and lipid metabolism, directly affect the proliferation and growth of liver cancer cells. Studies of ferroptosis regulation and lipid peroxidation may help to discover new therapeutic targets and improve therapeutic outcomes. The understanding of metabolic abnormalities can provide new ideas for the prevention of liver cancer, and reduce the risk of disease by adjusting the metabolic process. This review focuses on the key roles of ferroptosis regulation, lipid peroxidation and metabolic abnormalities in this process.

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Section: Regulatory Factors Involved In Ferroptosis Of Liver Cancermentioning

confidence: 99%

Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer

Shu,

Lao,

Qiu

2024

World J Gastrointest Oncol

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Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer

Wang,

Wang

et al. 2024

Advanced Therapeutics

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Phytochemicals are a diverse class of compounds found in various plant‐based foods and beverages that have displayed the capacity to exert powerful anticancer effects through the induction of programed cell death (PCD) in malignancies. PCD is a sophisticated process that maintains in upholding tissue homeostasis and eliminating injured or neoplastic cells. Phytochemicals have shown the potential to induce PCD in malignant cells through various mechanisms, including modulation of cell signaling pathways, regulation of reactive oxygen species (ROS), and interaction with critical targets in cells such as DNA. Moreover, recent studies have suggested that nanomaterials loaded with phytochemicals may enhance cell death in tumors, which can also stimulate antitumor immunity. In this review, a comprehensive overview of the current understanding of the anticancer effects of phytochemicals and their potential as a promising approach to cancer therapy, is provided. The impacts of phytochemicals such as resveratrol, curcumin, apigenin, quercetin, and some approved plant‐derived drugs, such as taxanes on the regulation of some types of PCD, including apoptosis, pyroptosis, anoikis, autophagic cell death, ferroptosis, and necroptosis, are discussed. The underlying mechanisms and the potential of nanomaterials loaded with phytochemicals to enhance PCD in tumors are also explained.

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Construction a six-gene prognostic model for hepatocellular carcinoma based on WGCNA co-expression network

Wang,

Fan,

Zhang

et al. 2024

Journal of Holistic Integrative Pharmacy

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Nitric oxide/paclitaxel micelles enhance anti-liver cancer effects and paclitaxel sensitivity by inducing ferroptosis, endoplasmic reticulum stress and pyroptosis

Abstract: The paclitaxel-containing micelle bearing NO donor (NO/PTX) exhibited improved anticancer effect in Bel-7402 cells and H22 xenograft mice by the modes of ferroptosis, pyroptosis, ERS and apoptosis-associated networks.

Cited by 3 publications

References 45 publications

Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer

Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer

Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer

Construction a six-gene prognostic model for hepatocellular carcinoma based on WGCNA co-expression network

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