Nitric oxide modulation of norepinephrine production in acupuncture points

Chen, Jiaxu; Ibe, Basil O.; Ma, Sheng-Xing

doi:10.1016/j.lfs.2006.07.009

Cited by 27 publications

(12 citation statements)

References 33 publications

(52 reference statements)

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“…L‐arginine‐derived NO synthesis modifies noradrenergic function, which contributes to low resistance characteristics of acupoints [4]. Consistently, enhanced 3H‐NE synthesis/release in acupoints/meridians is facilitated by the presence of an exogenous NO donor and inhibited by an inhibitor of NO synthesis [5]. Recent studies have demonstrated that EA stimulation of ST 36 increases the production of NO in arterioles [22].…”

Section: Discussionmentioning

confidence: 87%

Responses of Nitric Oxide–cGMP Release in Acupuncture Point to Electroacupuncture in Human Skin In Vivo Using Dermal Microdialysis

Jou

2009

Microcirculation

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Objectives-The purpose of this study was to examine the release of nitric oxide (NO) and cGMP in response to electroacupuncture (EA) stimulation in acupuncture point (acupoint) compared to nonmeridian control area.Methods-Thirty dermal microdialysis data were collected from 24 volunteers at pericardium (PC) 4 and control area. EA was applied to PC 3 by using a 5 voltage pulse with duration of 1.0 msec at 10 Hz for 15 min. Dialysate samples were continuously collected 20 min each before, during and after EA for 2 hr. Total nitrite and nitrate (NO x -) and cGMP in the dialysate were quantified in a blinded fashion. Results-Dialysate NO x-concentrations were decreased during a 120-min dialysis in all groups but reduced NO x -levels were attenuated predominantly in PC 4 acupoint at 20-40 min after EA PC 3. cGMP concentrations were significantly enhanced in acupoint PC 4 by EA PC 3, but not in nonmeridian area. Conclusion-We suggest that attenuation of NO x-reduction during dialysis reflects an increase in NO release induced by EA stimulation in acupoint and that cGMP mediates the signaling functions of NO to improve local microcirculation, which at least in part contributes to the effects of acupuncture.

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Section: Discussionmentioning

confidence: 87%

Responses of Nitric Oxide–cGMP Release in Acupuncture Point to Electroacupuncture in Human Skin In Vivo Using Dermal Microdialysis

Jou

2009

Microcirculation

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“…EA stimulation induces a significant release of NO following dermal microdialysis in the acupoint but not in the NMCR in humans [35]. L-arginine-derived NO synthesis increases low resistance characteristics of acupoints [37], and norepinephrine turnover rate in acupoints/meridians is facilitated by presence of NO [38]. Consistently, cutaneous vasodilation induced by acupuncture stimulation in the forearms of humans is attenuated by application of NO synthesis inhibitor, which suggest that L-arginine-derived NO synthesis contributes to cutaneous vasodilation induced by acupuncture stimulation [39].…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous Electrical Stimulation Increased Nitric Oxide-Cyclic GMP Release Biocaptured Over Skin Surface of Pericardium Meridian and Acupuncture Points in Humans

Ma¹,

Mayer²,

Lee³

et al. 2015

acupunct electrother res

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Objectives The purpose of this study was to consecutively capture and quantify nitric oxide (NO) and cGMP, the second messenger of NO, over the skin surface of acupuncture points (acupoints), meridian line without acupoint, and non-meridian control regions of the Pericardium meridian (PC) in humans, and investigate their response to transcutaneous electrical nerve stimulation (TENS). Design, setting, and main outcome measures Adhesive biocapture tubes were attached to the skin surface along PC regions and injected with 2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl solution, an NO-scavenging compound, contacting the skin surface for 20 minutes each during 4 consecutive biocapture intervals. TENS (1.0 mA, 6 Hz, 1.0 msec duration) was applied over acupoints PC 8 and PC 3 during the 2nd biocapture for 20 min. Total nitrite and nitrate (NOx-), the stable metabolic products of NO, and cGMP in biocaptured samples were quantified using chemiluminescence and ELISA. Results NOx- levels in the 1st biocapture over PC regions are almost two fold higher compared to subsequent biocaptures and are higher over PC acupoints versus non-meridian control region. Following TENS, NOx- concentrations over PC regions were significantly increased, and cGMP is predominantly released from the skin surface of PC acupoints. Conclusions TENS induces elevations of NO-cGMP concentrations over local skin region with a high level at acupoints. The enhanced signal molecules improve local circulation, which contributes to beneficial effects of the therapy.

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“…Hypertension is an important presenting feature of renal disease and is probably one of the most important factors contributing to the progression of CKD [6,31,32] . Recent studies have demonstrated that EA on the stomach at the 36th point (ST-36) induces upregulation of neuronal nitric oxide synthase (NOS) expression in the gracile nucleus and medial nucleus tractus solitarius, and this can modify central cardiovascular regulation [33,34] . Kim et al [35] demonstrated that EA on ST-36 reduces blood pressure by modulation of endothelial NOS and neuronal NOS expression.…”

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confidence: 99%

Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

Paterno

Freire

Soares³

et al. 2008

Kidney Blood Press Res

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Background/Aim: Chronic kidney disease is a worldwide public health problem and the prevention of its progression is still a major challenge in nephrology. Specific therapies that inhibit or attenuate this process are neither available nor satisfactory. Traditional Chinese medicine has been increasingly recognized as an effective therapeutic approach in several fields of medicine. The aim of this study was to investigate the effects of electroacupuncture (EA) and moxibustion (MO) in an experimental model of progressive renal disease in rats. Methods: Twenty-one male Wistar rats were submitted to 5/6th nephrectomy (NX) and assessed 8 weeks later and were divided into three groups: NX = only 5/6 NX, NX-AS = 5/6 NX and a 20-min EA-MO session in sham points, and NX-AM = 5/6 NX and a 20-min EA-MO session in three real acupuncture points. The treatment consisted of 16 sessions twice a week. Renal function, urine volume, serum creatinine, 24-hour proteinuria, direct and indirect blood pressure, glomerulosclerosis and tubulointerstitial fibrosis indices were assessed. Results: The NX-AM group showed a significant decrease in all investigated parameters when compared to the control groups. Conclusion: Our results suggest that EA and MO attenuated the progression of renal disease in the experimental model of 5/6 NX.

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Nitric oxide modulation of norepinephrine production in acupuncture points

Cited by 27 publications

References 33 publications

Responses of Nitric Oxide–cGMP Release in Acupuncture Point to Electroacupuncture in Human Skin In Vivo Using Dermal Microdialysis

Responses of Nitric Oxide–cGMP Release in Acupuncture Point to Electroacupuncture in Human Skin In Vivo Using Dermal Microdialysis

Transcutaneous Electrical Stimulation Increased Nitric Oxide-Cyclic GMP Release Biocaptured Over Skin Surface of Pericardium Meridian and Acupuncture Points in Humans

Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

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