Nitric oxide modulates renal sensory nerve fibers by mechanisms related to substance P receptor activation

Kopp, Ulla C.; Cicha, Michael Z.; Smith, Lori; Hökfelt, Tomas

doi:10.1152/ajpregu.2001.281.1.r279

Cited by 43 publications

(69 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A PE-50 catheter placed in the left ureter was used to increase renal pelvic pressure by elevating its free end above the kidney. 1,5,11 ARNA was recorded from the peripheral portion of the cut end of 1 renal nerve. ARNA integrated over 1-second intervals was expressed as a percentage of that at baseline.…”

Section: Recording Of Pulsatile Arterial Pressure In Conscious Ratsmentioning

confidence: 99%

“…ARNA integrated over 1-second intervals was expressed as a percentage of that at baseline. 1,[5][6][7][8][9]11,12 Effects of Increasing Renal Pelvic Pressure on ARNA DRX rats (nϭ9) and sham-DRX rats (nϭ10) fed the HNa diet were studied. Renal pelvic pressure was increased by 5 and 15 mm Hg, in random order, for two 5-minute experimental periods bracketed by 10-minute control and recovery periods.…”

Section: Recording Of Pulsatile Arterial Pressure In Conscious Ratsmentioning

confidence: 99%

“…1,2 The afferent renal nerves project to the ipsilateral dorsal root ganglia at the T 6 -L 2 level, with the majority of cell bodies of the afferent renal nerves being at the T 9 -L 1 level. 3,4 The renal sensory nerves are activated by increases in renal pelvic pressure within the physiologic range.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Dietary Sodium Loading Increases Arterial Pressure in Afferent Renal–Denervated Rats

2003

Self Cite

View full text Add to dashboard Cite

Abstract-In rats fed high sodium diet, increasing renal pelvic pressure Ն3 mm Hg activates renal mechanosensory nerves, resulting in a renorenal reflex-induced increase in urinary sodium excretion. The low activation threshold of the renal mechanosensory nerves suggests a role for natriuretic renorenal reflexes in the regulation of arterial pressure and sodium balance. If so, interruption of the afferent renal innervation by dorsal rhizotomy (DRX) at T 9 -L 1 would impair urinary sodium excretion and/or increase arterial pressure during high dietary sodium intake. DRX and sham-DRX rats were fed either a high or a normal sodium diet for 3 weeks. Mean arterial pressure measured in conscious rats was higher in DRX than in sham-DRX rats fed a high sodium diet, 130Ϯ2 vs 100Ϯ3 mm Hg (PϽ0.01). However, mean arterial pressure was similar in DRX and sham-DRX rats fed a normal sodium diet, 115Ϯ1 and 113Ϯ1 mm Hg, respectively. Steady-state urinary sodium excretion was similar in DRX and sham-DRX rats on high (17.9Ϯ2.2 and 16.4Ϯ1.8 mmol/24 h, respectively) and normal (4.8Ϯ0.3 and 5.0Ϯ0.4 mmol/24 h, respectively) sodium diets. Studies in anesthetized rats showed a lack of an increase in afferent renal nerve activity in response to increased renal pelvic pressure and impaired prostaglandin E 2 -mediated release of substance P from the renal pelvic nerves in DRX rats fed either a high or a normal sodium diet, suggesting that DRX resulted in decreased responsiveness of peripheral renal sensory nerves. In conclusion, when the afferent limb of the renorenal reflex is interrupted, a high sodium diet results in increased arterial pressure to facilitate the natriuresis and maintenance of sodium balance. Key Words: renal nerves Ⅲ hypertension, sodium dependent Ⅲ sodium, dietary Ⅲ urine Ⅲ natriuresis I n the kidney, the majority of renal sensory nerves containing substance P are located in the renal pelvic wall. 1,2 The afferent renal nerves project to the ipsilateral dorsal root ganglia at the T 6 -L 2 level, with the majority of cell bodies of the afferent renal nerves being at the T 9 -L 1 level. 3,4 The renal sensory nerves are activated by increases in renal pelvic pressure within the physiologic range. 5 The increase in afferent renal nerve activity (ARNA) produced by the increased renal pelvic pressure leads to a reflex decrease in efferent renal sympathetic nerve activity (ERSNA) and diuresis and natriuresis, ie, a renorenal reflex response. 6 Increasing renal pelvic pressure elicits a series of events eventually leading to increases in ARNA. Among the various mechanisms activated by increased renal pelvic pressure is stimulation of bradykinin-2 receptors that activate protein kinase C, which leads to activation of cyclooxygenase-2 and increased prostaglandin E 2 (PGE 2 ) synthesis. 7-9 PGE 2 activates cAMP, which leads to a calcium-dependent release of substance P from the renal sensory nerves. 10,11 Substance P increases ARNA by stimulating neurokinin-1 receptors. 12 The responsiveness of renal sensory nerves is modulated by...

show abstract

Section: Recording Of Pulsatile Arterial Pressure In Conscious Ratsmentioning

confidence: 99%

Section: Recording Of Pulsatile Arterial Pressure In Conscious Ratsmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Sodium Loading Increases Arterial Pressure in Afferent Renal–Denervated Rats

2003

Self Cite

View full text Add to dashboard Cite

show abstract

“…1,2,6,7,9,10 In brief, after anesthesia, renal pelvises dissected from the kidneys were placed in wells containing 400 L of HEPES buffer (pH 7.4), 37°C, containing indomethacin (0.14 mmol/L) to minimize the influence of endogenous PGE 2 on substance P release. Each well contained the pelvic wall from 1 kidney.…”

Section: Substance P Release From An Isolated Renal Pelvic Wall Prepamentioning

confidence: 99%

“…[1][2][3] Activation of these nerves by increases in renal pelvic pressure results in increases in afferent renal nerve activity (ARNA) leading to reflex decreases in efferent renal sympathetic nerve activity and diuresis and natriuresis, that is, a renorenal reflex response. 4 Among the various mechanisms activated by stretching the renal pelvic wall is induction of cyclooxygenase-2 resulting in increased renal pelvic synthesis of PGE 2 .…”

mentioning

confidence: 99%

Activation of Endothelin-A Receptors Contributes to Angiotensin-Induced Suppression of Renal Sensory Nerve Activation

2007

Self Cite

View full text Add to dashboard Cite

Abstract-Activation of renal mechanosensory nerves is enhanced by a high-sodium diet and suppressed by a low-sodium diet. Angiotensin (Ang) II and endothelin (ET)-1 each contributes to the impaired responsiveness of renal mechanosensory nerves in a low-sodium diet. We examined whether stimulation of ETA receptors (Rs) contributes to Ang II-induced suppression of the responsiveness of renal mechanosensory nerves. In anesthetized rats fed a low-sodium diet, renal pelvic administration of the Ang type I receptor (AT1-R) antagonist losartan enhanced the afferent renal nerve activity (ARNA) response to increasing renal pelvic pressure 7.5 mm Hg from 7Ϯ2% to 15Ϯ2% and the prostaglandin (PG) E 2 -mediated substance P release from 0Ϯ1 to 8Ϯ1 pg/min. Adding the ETA-R antagonist BQ123 to the renal pelvic perfusate containing losartan did not produce any further enhancement of the ARNA response or PGE 2 -mediated release of substance P (17Ϯ3% and 8Ϯ1 pg/min). Likewise, renal pelvic administration of BQ123 and BQ123ϩlosartan resulted in similar enhancements of the ARNA responses to increased renal pelvic pressure and PGE 2 -mediated substance P release. In high-sodium-diet rats, pelvic administration of Ang II reduced the ARNA response to increased renal pelvic pressure from 27Ϯ4% to 8Ϯ3% and the PGE 2 -mediated substance P release from 9Ϯ0 to 1Ϯ1 pg/min. Adding BQ123 to the renal pelvic perfusate containing Ang II restored the increases in ARNA and the PGE 2 -mediated substance P release toward control (27Ϯ6% and 7Ϯ1 pg/min). In conclusion, stimulation of ETA-R plays an important contributory role to the Ang II-mediated suppression of the activation of renal mechanosensory nerves in conditions of low-sodium diet. Key Words: ETA-receptors Ⅲ AT1-receptors Ⅲ afferent renal nerves Ⅲ PGE 2 Ⅲ substance P Ⅲ BQ123 Ⅲ losartan T he majority of the afferent renal nerves are located in the renal pelvic wall. 1-3 Activation of these nerves by increases in renal pelvic pressure results in increases in afferent renal nerve activity (ARNA) leading to reflex decreases in efferent renal sympathetic nerve activity and diuresis and natriuresis, that is, a renorenal reflex response. 4 Among the various mechanisms activated by stretching the renal pelvic wall is induction of cyclooxygenase-2 resulting in increased renal pelvic synthesis of PGE 2 . 5,6 PGE 2 leads to activation of the cAMP-protein kinase A transduction pathway and a release of the neuropeptide substance P, which activates the afferent renal nerves by stimulating neurokinin-1 receptors in the renal pelvic area. 1,7,8 The responsiveness of the afferent renal nerves is enhanced by high-sodium diet and suppressed by low-sodium diet because of an interaction between prostaglandin (PG) E 2 (PGE 2 ) and angiotensin (Ang) II at the peripheral renal sensory nerve endings. 7,9,10 In conditions of high-sodium diet, characterized by low endogenous Ang II, 11 there is little or no inhibition of the PGE 2 -mediated activation of adenylyl cyclase. Conversely, in conditions of low-sodium diet, ...

show abstract

Phototherapie gegen Rückenschmerzen

Cherenack

Born

Liebmann³

et al. 2013

Biologie in unserer Zeit

View full text Add to dashboard Cite

Im Rahmen phototherapeutischer Anwendungen werden inzwischen immer häufiger LEDs (Licht emittierende Dioden) eingesetzt, da sie für die medizinische Nutzung verschiedene Vorteile bieten, wie beispielsweise eine hohe spektrale Selektivität bei kompakter Bauweise und den Betrieb im Niedervoltbereich. Ersteres bedeutet, dass derartige Lichtquellen ohne Verwendung zusätzlicher Filter auskommen und spezielle Lichtbereiche (z. B. den Wellenlängenbereich von blauem Licht) mit hoher Genauigkeit bei gleichzeitig hohen Bestrahlungsstärken abdecken können. Dies ermöglicht es, Versuche mit spezifischen Wellenlängen durchzuführen und dabei die Lichtwirkung genau zu untersuchen. Die lichterzeugenden Komponenten von "BlueTouch" werden mit elektrisch leitfähigen Garnen in eine textile Plattform eingewoben. Im nächsten Abschnitt wird ein einfacher Herstellungsprozess näher beschrieben, bei dem elektronische Bauteile und LED-Komponenten in eine textile Umgebung unter Berücksichtigung industrieller Kompatibilitäten integriert werden. Herstellung von Photonischen TextilienDurch die Kombination der sehr unterschiedlichen Herstellungstechnologien für textile und elektronische Komponenten haben wir hochleistungsfähige Textilsysteme mit integrierten elektronischen und lichtemittierenden Funktionen hergestellt. Hierbei können beispielsweise automatische Webprozesse zur Herstellung großer Oberflächen bei sehr hohen Geschwindigkeiten genutzt werden. Der erste Schritt bei der Herstellung von Photonischen Textilien beginnt mit der Textilkette bei einer Webfabrik. Je nach Art wird das elektrisch leitfähige Garn in ein Textil mittels eines spezifischen Musters eingewoben. Das Garn wird dabei an die Oberfläche des Textils angebracht, um dort die Menschen tragen schon seit hunderten von Jahren Stoffe zum Wärmen, zum Schutz gegen die Elemente und als Körperschmuck. Seit einigen Jahren versuchen Forscher und Wissenschaftler, weitere Funktionen in Textilien zu integrieren. Textile Systeme mit eingebauter Elektronik sollen den Menschen im täglichen Leben unterstützen. Was "intelligente" Textilien heute können Phototherapie gegen Rückenschmerzen KUNIGUNDE CHERENACK | MATTHIAS BORN | JOERG LIEBMANN | CHRISTOPH SUSCHEK

show abstract

Nitric oxide modulates renal sensory nerve fibers by mechanisms related to substance P receptor activation

Abstract: activation of NO may function as an inhibitory neurotransmitter regulating the activation of renal mechanosensory nerve fibers by mechanisms related to activation of substance P receptors.

Cited by 43 publications

References 65 publications

Dietary Sodium Loading Increases Arterial Pressure in Afferent Renal–Denervated Rats

Dietary Sodium Loading Increases Arterial Pressure in Afferent Renal–Denervated Rats

Activation of Endothelin-A Receptors Contributes to Angiotensin-Induced Suppression of Renal Sensory Nerve Activation

Phototherapie gegen Rückenschmerzen

Contact Info

Product

Resources

About