Nitric oxide mediates red light-induced perylenequinone production in Shiraia mycelium culture
Wen Juan Wang,
Xin Ping Li,
Wen Hao Shen
et al.
Abstract:Perylenequinones (PQs) from bambusicolous Shiraia fungi serve as excellent photosensitizers for photodynamic therapy. However, the lower yield of PQ production in mycelium cultures is an important bottleneck for their clinical application. Light has long been recognized as a pivotal regulatory signal for fungal secondary metabolite biosynthesis. In this study, we explored the role of nitric oxide (NO) in the growth and PQ biosynthesis in mycelium cultures of Shiraia sp. S9 exposed to red light. The continuous … Show more
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