Nitric Oxide Mediated Vasoreactivity During Fracture Repair

Corbett, S. A.; McCarthy, Ian; Batten, J.; Hukkanen, Mika; Polak, Julia M.; Hughes, Sean

doi:10.1097/00003086-199908000-00030

Cited by 33 publications

(25 citation statements)

References 31 publications

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“…NO is expressed during fracture healing, and suppression of NOS impairs fracture healing 7. Similar results by Corbett et al 6. show that NO-mediated vasoreactivity is maximal in early phases of fracture healing, before returning to basal levels, as healing progresses.…”

Section: Discussionsupporting

confidence: 62%

Effect of amino acids lysine and arginine on fracture healing in rabbits: A radiological and histomorphological analysis

Sinha¹,

Goel²

2009

Indian J Orthop

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Background:Amino acids like arginine and lysine have been suggested to hasten the process of fracture healing by improving the local blood supply, supplementing growth factors, and improving collagen synthesis. We studied the role of lysine and arginine in the fracture repair process with regard to the rate of healing, probable mechanisms involved in the process, and mutual synergism between these agents.Materials and Methods:In an experimental study, 40 rabbits were subjected to ulnar osteotomy. They were distributed in control (14) and test groups (26). Twenty-six animals in the test group were fed with a diet rich in lysine and arginine. Both the groups were followed radiologically and histologically till union.Results:There was better healing of osteotomy in terms of better vascularization, callus formation, and mineralization in the test group. The time of healing in the test group was reduced by a period of 2 weeks.Conclusion:We conclude that amino acids like arginine and lysine may hasten fracture healing.

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Section: Discussionsupporting

confidence: 62%

Effect of amino acids lysine and arginine on fracture healing in rabbits: A radiological and histomorphological analysis

Sinha¹,

Goel²

2009

Indian J Orthop

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“…The decreased arginine concentrations, as an NO precursor, in the callus of atrophic bone samples in our study are in line with these findings. In addition, neovascularization and vasoreactivity are essential during normal fracture healing, and NO also mediates this vasoreactivity and controls angiogenesis during fracture healing (9). Vascular reactivity in healing of rat femur fractures is stimulated by the NO stimulator acetylcholine (9) Disturbances in amounts of arginine, which is the sole precursor of NO, might contribute to the development of impaired fracture healing because arginine is one of the conditionally essential amino acids involved in fracture healing (21).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, neovascularization and vasoreactivity are essential during normal fracture healing, and NO also mediates this vasoreactivity and controls angiogenesis during fracture healing (9). Vascular reactivity in healing of rat femur fractures is stimulated by the NO stimulator acetylcholine (9) Disturbances in amounts of arginine, which is the sole precursor of NO, might contribute to the development of impaired fracture healing because arginine is one of the conditionally essential amino acids involved in fracture healing (21). Comparable processes are present during wound healing or inflammatory conditions, which make sufficient arginine and NO availability essential for normal tissue regeneration (22,23).…”

Section: Discussionmentioning

confidence: 99%

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Impaired fracture healing associated with amino acid disturbances

Wijnands¹,

Brink²,

Weijers³

et al. 2012

The American Journal of Clinical Nutrition

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“…L-arginine is a semi-essential amino acid and serves as a substrate for production of nitric oxide (NO) that improves endothelial function, reduces vascular resistance, promotes angiogenesis, and influences numerous metabolic processes [69, 70]. Experimental studies have determined that nitric oxide is released in response to mechanical stress on bone, and that blocking the release of nitric oxide interferes with fracture healing [71, 72]. Dietary arginine is available in dairy products, poultry, seafood, and meat in addition to nuts and oatmeal.…”

Section: Lesser Known Nutritional Needsmentioning

confidence: 99%

Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet

Price¹,

Langford²,

Liporace³

2012

TOORTHJ

116

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Osteoporosis and low bone mineral density affect millions of Americans. The majority of adults in North America have insufficient intake of vitamin D and calcium along with inadequate exercise. Physicians are aware that vitamin D, calcium and exercise are essential for maintenance of bone health. Physicians are less likely to be aware that dietary insufficiencies of magnesium, silicon, Vitamin K, and boron are also widely prevalent, and each of these essential nutrients is an important contributor to bone health. In addition, specific nutritional factors may improve calcium metabolism and bone formation. It is the authors’ opinion that nutritional supplements should attempt to provide ample, but not excessive, amounts of factors that are frequently insufficient in the typical American diet.In contrast to dietary insufficiencies, several nutrients that support bone health are readily available in the average American diet. These include zinc, manganese, and copper which may have adverse effects at higher levels of intake. Some multivitamins and bone support products provide additional quantities of nutrients that may be unnecessary or potentially harmful.The purpose of this paper is to identify specific nutritional components of bone health, the effects on bone, the level of availability in the average American diet, and the implications of supplementation for each nutritional component. A summary of recommended dietary supplementation is included.

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Nitric Oxide Mediated Vasoreactivity During Fracture Repair

Cited by 33 publications

References 31 publications

Effect of amino acids lysine and arginine on fracture healing in rabbits: A radiological and histomorphological analysis

Effect of amino acids lysine and arginine on fracture healing in rabbits: A radiological and histomorphological analysis

Impaired fracture healing associated with amino acid disturbances

Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet

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