Nitric oxide, lipid peroxidation products, and antioxidants in primary fibromyalgia and correlation with disease severity

Shukla, Vibha; Kumar, Das Siddharth; Mahdi, Abbas Ali; Agarwal, Shweta; Khandpur, Sukhanshi

doi:10.2478/jomb-2019-0033

Cited by 15 publications

(19 citation statements)

References 28 publications

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“…This enzyme is not secreted by the salivary glands so its concentration in saliva reflects its concentration in blood [ 19 ]. Previous studies showed a lower catalase activity in blood in people with fibromyalgia than in healthy people [ 47 , 48 , 49 ]. This could indicate that people with FM have more susceptibility to the deleterious effects of ROS.…”

Section: Discussionmentioning

confidence: 99%

“…Reduced concentration in thiol-rich compounds (including glutathione) was described in fibromyalgia blood samples [ 47 , 49 ]. Additionally, in red blood cells from people with fibromyalgia, a lower GPx activity was found [ 48 ]. These results also underline the lower antioxidative capacity of people with fibromyalgia [ 17 , 47 , 48 , 49 , 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

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Heart Rate Variability and Salivary Biomarkers Differences between Fibromyalgia and Healthy Participants after an Exercise Fatigue Protocol: An Experimental Study

Costa

Freire²,

Parraça³

et al. 2022

Diagnostics

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Previous studies showed that people with Fibromyalgia (FM) suffer from dysautonomia. Dysautonomia consists of persistent autonomic nervous system hyperactivity at rest and hyporeactivity during stressful situations. There is evidence that parameters reflecting the complex interplay between the autonomic nervous system and the cardiovascular system during exercise can provide significant prognostic information. Therefore, this study aimed to investigate the differences between people with FM and healthy controls on heart rate variability (HRV) and salivary parameters (such as flow, protein concentration, enzymatic activities of amylase, catalase and glutathione peroxidase) in two moments: (1) at baseline, and (2) after an exercise fatigue protocol. A total of 37 participants, twenty-one were people with fibromyalgia and sixteen were healthy controls, participated in this cross-sectional study. HRV and salivary samples were collected before and after an exercise fatigue protocol. The fatigue protocol consisted of 20 repetitions of knee extensions and flexions of the dominant leg at 180 °·s−1 (degrees per second). Significant differences were found in the HRV (stress index, LF and HF variables) and salivary biomarkers (with a higher concentration of salivary amylase in people with FM compared to healthy controls). Exercise acute effects on HRV showed that people with FM did not significantly react to exercise. However, significant differences between baseline and post-exercise on HRV significantly induce alteration on the HRV of healthy controls. Catalase significantly increased after exercise in healthy controls whereas salivary flow significantly increased in women with FM after an exercise fatigue protocol. Our study suggests that a higher α-amylase activity and an impaired HRV can be used as possible biomarkers of fibromyalgia, associated with a reduction in salivary flow without changes in HRV and catalase activity after a fatigue exercise protocol. More studies should be carried out in the future to evaluate this hypothesis, in order to find diagnostic biomarkers in fibromyalgia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability and Salivary Biomarkers Differences between Fibromyalgia and Healthy Participants after an Exercise Fatigue Protocol: An Experimental Study

Costa

Freire²,

Parraça³

et al. 2022

Diagnostics

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“…Studies have suggested that NO might play a dual role in cancer progression, depending on its concentration, and can act as a protumor or antitumor factor 57. Therefore, elevated NO levels in patients with leukemia can lead to a variety of chemical reactions in the biological system, including the induction of lipid peroxidation, inhibition of mitochondrial electron transfer, disruption of the antioxidant system, and ultimately exacerbation of the disease 58…”

Section: Discussionmentioning

confidence: 99%

Organochlorine Pesticides, Oxidative Stress Biomarkers, and Leukemia: A Case-Control Study

Rafeeinia

Asadikaram

Karimi-Darabi

et al. 2022

Journal of Investigative Medicine

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Exposure to pesticides has been linked to an elevated risk of leukemia. The present research aimed to evaluate the relationship between organochlorine (OC) pesticides and biomarkers of oxidative stress in patients with leukemia. This work was conducted on 109 patients with leukemia and 109 healthy controls. The serum concentrations of seven derivatives of OCs including alpha-hexachlorocyclohexane (HCH), beta-HCH, gamma-HCH, 2,4-dichlorodiphenyltrichloroethane (DDT), 4,4-DDT, 2,4-dichlorodiphenyldichloroethylene (DDE), and 4,4-DDE along with acetylcholinesterase (AChE), glutathione peroxidase (GPx), superoxide dismutase (SOD), paraoxonase-1 (PON1), and catalase (CAT) activities as well as total antioxidant capacity (TAC), nitric oxide (NO), protein carbonyl (PC), and malondialdehyde (MDA) levels were measured in all the subjects. Levels of OCs were remarkably higher in patients with leukemia compared with the controls (p<0.05). In addition, levels of SOD, AChE, GPx, PON1, and TAC were remarkably lower in patients with leukemia compared with controls (p<0.05). In contrast, MDA, NO, and PC concentrations were higher in patients with leukemia than in the controls (p<0.05). Moreover, the serum level of 4,4-DDE was negatively associated with GPx activity (p=0.038). Our findings suggest that OCs may play a role in the development of leukemia by disrupting the oxidant/antioxidant balance.

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“…To date, efforts in this direction have shown that oxidative stress may play a number of roles in the pathogenesis and severity of this disease. Shukla et al[ 37 ] reported a strong positive relationship between the FIQ scores and oxidative stress, which was exhibited by nitric oxide and lipid peroxidation. In the same study, a strong negative correlation between the FIQ scores and antioxidant enzymes was observed.…”

Section: Discussionmentioning

confidence: 99%

The relationship between dietary total antioxidant capacity, clinical parameters, and oxidative stress in fibromyalgia syndrome: A novel point of view

Adıgüzel¹,

Köroğlu²,

Yaşar³

et al. 2022

Turk J Phys Med Rehab

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Objectives: This study aims to reveal the relationship between serum total antioxidant status (TAS), clinical parameters, and nutrition (dietary total antioxidant capacity [TAC]) in patients with fibromyalgia. Patients and methods: This cross-sectional study was conducted with a total of 60 female participants (mean age: 44.7±9.7 years; range, 18 to 50 years) at Gaziler Physical Medicine and Rehabilitation Hospital between July 2020 and February 2021. Thirty female patients with fibromyalgia were compared with 30 age-, sex-, and body mass index-matched healthy individuals. The short-form McGill Pain Questionnaire, Fibromyalgia Impact Questionnaire (FIQ), and Pittsburg Sleep Quality Index were used. Total antioxidant status, total oxidant status (TOS), and oxidative stress index (OSI) were measured. Dietary TAC was calculated using the ferric reducing ability of plasma according to a food frequency questionnaire. Results: Total antioxidant status showed no significant difference between groups (p=0.080). Total oxidant status and OSI were significantly higher in the patient group (p<0.001 and p=0.005, respectively). The mean dietary TAC was 16.5±6.5 in the patient group and 17.2±6.2 in the control group, and it was similar between groups (p=0.492). Pittsburg Sleep Quality Index global score was significantly higher in the patient group than in the control group (p<0.001). Dietary TAC showed a moderate positive correlation with serum TAS in both groups (r=0.373, p=0.042 for the patient group, and r=0.380, p=0.038 for the control group). In the patient group, TOS and OSI showed a moderate positive correlation with FIQ total scores (r=0.420, p=0.021 and r=0.450, p=0.013, respectively). The mean polyunsaturated fatty acid and omega-6 intake of the patient group was significantly lower than the control group (p=0.025 for both). Dietary antioxidant intake from vegetables (p=0.025), legumes/nuts (p=0.049), and meat (p<0.001) was significantly lower, whereas dietary antioxidant intake from cereal and potatoes was significantly higher in the patient group compared to the control group (p=0.028). Conclusion: The results indicate that oxidative stress can be reduced by increasing dietary antioxidant intake in fibromyalgia.

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Nitric oxide, lipid peroxidation products, and antioxidants in primary fibromyalgia and correlation with disease severity

Cited by 15 publications

References 28 publications

Heart Rate Variability and Salivary Biomarkers Differences between Fibromyalgia and Healthy Participants after an Exercise Fatigue Protocol: An Experimental Study

Heart Rate Variability and Salivary Biomarkers Differences between Fibromyalgia and Healthy Participants after an Exercise Fatigue Protocol: An Experimental Study

Organochlorine Pesticides, Oxidative Stress Biomarkers, and Leukemia: A Case-Control Study

The relationship between dietary total antioxidant capacity, clinical parameters, and oxidative stress in fibromyalgia syndrome: A novel point of view

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