Nitric oxide levels in response to the patients with different stage of diabetes

Abstract

The association between hyperglycaemia and serum nitric oxide (NO) levels has not yet been fully clarified. Thus, it was aimed to evaluate the concentration of NO metabolites (nitrate, nitrite) in diabetic patients and to find the relationship between hyperglycaemia and serum NO levels in diabetic and prediabetic patients, and control groups. In this study, 100 subjects were divided into 3 groups: healthy control (n=20), prediabetic (n=40) and diabetic (n=40). Glycemic control was assessed using glycated hemoglobin (HbA1c). Nitrate and nitrite levels were measured using the Griess reagent. NO was obtained from the sum of nitrates and nitrites. The serum NO level was higher in diabetic (53.4±2.0 μM) and prediabetic patients (51.6±1.6 μM) as compared to that in the control (45.6±1.2 μM), (p<0.05). The NO level was not significantly different in diabetic and prediabetic patients. Higher levels of serum glucose, insulin and HOMA-IR may be responsible for the activation of endothelial cells to increase NO levels. This study supports the role of insulin resistance in increased NO levels in both diabetic and prediabetic patients.

Effect of glycemic control and disease duration on cardiac autonomic function and oxidative stress in type 2 diabetes mellitus

“…Their findings were in agreement with the observations of [42,43]. More recently, Ozcelik and Algul [44] also found higher NO levels in not only diabetics but prediabetics as well.…”

Two months sodium nitrate supplementation alleviates testicular injury in streptozotocin‐induced diabetic male rats

“…Increase (Assmann et al., ; Ozcelik & Algul, ), decrease (Khalifi et al., ), and no change (Schmetterer et al., ) of serum NOx levels have been reported in diabetes. Two months administration of nitrate increased NOx levels to near those of the control group.…”

“…Increase (Assmann et al, 2016;Ozcelik & Algul, 2017), decrease (Khalifi et al, 2015), and no change (Schmetterer et al, 1997) Peleli et al, 2016). One study showed increased serum NOx levels following nitrate supplementation in diabetic rats after 8 weeks (Khalifi et al, 2015); in another study, serum nitrate levels on day 42 in nitrate-treated diabetic rats were lower than in nitratetreated controls (Gheibi et al, 2018).…”

COX2 and NOS3 gene polymorphisms in women with gestational diabetes

“…The COX2 and NOS3 gene polymorphisms alter COX2 and NOS3 gene expression, as well as cyclooxygenase and nitric oxide synthesis. Cyclooxygenase and nitric oxide are important mediators of the inflammatory response in diabetes . Low grade inflammation has been shown to play a significant role in the pathogenesis of GDM …”

“…Cyclooxygenase and nitric oxide are important mediators of the inflammatory response in diabetes. [23][24][25][26][27] Low grade inflammation has been shown to play a significant role in the pathogenesis of GDM. [3][4][5] Apgar (0-10) 9.9 ± 0.4 9.7 ± 1.0…”