Nitric Oxide Levels in Disruptive Behavioral Disorder

Taş, Fatma; Güvenir, Taner; Tas, Gultekin; Çakaloz, Burcu; Örmen, Murat

doi:10.1159/000093781

Cited by 19 publications

(13 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the SHR, damaged non-selective attention was improved with the nitric oxide synthase (NOS) inhibitor l -nitro-arginine methyl ester ( l -NAME) [ 69 ]. In contrast, reduced blood NO levels have been reported [ 70 ]. On the other hand, NO levels were significantly higher in ADHD [ 53 , 71 ].…”

Section: Role Of Oxidative Stressmentioning

confidence: 99%

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Corona

2020

Antioxidants

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder of childhood. Although abnormalities in several brain regions and disturbances of the catecholaminergic pathway have been demonstrated, the pathophysiology of ADHD is not completely understood, but as a multifactorial disorder, has been associated with an increase in oxidative stress and neuroinflammation. This review presents an overview of factors that increase oxidative stress and neuroinflammation. The imbalance between oxidants and antioxidants and also the treatment with medications are two factors that can increase oxidative damage, whereas the comorbidity between ADHD and inflammatory disorders, altered immune response, genetic and environmental associations, and polymorphisms in inflammatory-related genes can increase neuroinflammation. Evidence of an association with these factors has become valuable for research on ADHD. Such evidence opens up new intervention routes for the use of natural products as antioxidants that could have potential as a treatment against oxidative stress and neuroinflammation in ADHD.

show abstract

Section: Role Of Oxidative Stressmentioning

confidence: 99%

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Corona

2020

Antioxidants

View full text Add to dashboard Cite

show abstract

“…21 Low levels of oxidant nitric oxide (NO) have also been reported in children with ADHD. 22 Furthermore, it has been shown that malondialdehyde (MDA) is statistically significantly low in children with ADHD. 23 In addition, in some studies oxidative stress was found to be increased in patients with ADHD.…”

Section: Introductionmentioning

confidence: 99%

Increased oxidative stress in children with attention deficit hyperactivity disorder

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The results indicate that sex plays a role in NO levels among ASD children. It was the first time that precise concentrations of serum nitrite and nitrate were independently disclosed among children aged between 2 and 10 years old, though the sum of nitrite and nitrate had been reported before ( Table 2 ) [ 19 , 22 , 29 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Saliva nitrite is higher in male children with autism spectrum disorder and positively correlated with serum nitrate

Yao

Bai

et al. 2021

Redox Report

View full text Add to dashboard Cite

Objectives Nitric oxide (NO) plays a vital role in neurological development. As an easily accessible and non-invasive fluid, saliva hasn't been evaluated for nitrite among children with autism spectrum disorder (ASD). This study aims to quantify saliva nitrite and explore its relation with serum NO. Methods Saliva sampling and pretreatment methods were optimized, followed by NO measurement via chemiluminescence for 126 ASD children and 129 normally developing children (ND). Results In the ASD group, saliva nitrite was significantly higher than that in the ND, with concentrations of 4.97 ± 3.77 μM and 2.66 ± 2.07 μM ( p < 0.0001), respectively. Positive correlation was observed between saliva NO 2 − and serum NO 3 − in ASD children, which didn't exist in the ND group. Male children in the ASD group had significantly higher NO than that in boys of the ND group, without significant difference between girls in both groups. Correlation was not found between saliva or serum NO and severity of these ASD children. Discussion It is reported for the first time that saliva nitrite was positively correlated with serum nitrate in ASD children, with significantly higher NO only in autistic boys. Non-invasive saliva might serve as a predictor of health status of ASD children.

show abstract

Nitric Oxide Levels in Disruptive Behavioral Disorder

Cited by 19 publications

References 59 publications

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Increased oxidative stress in children with attention deficit hyperactivity disorder

Saliva nitrite is higher in male children with autism spectrum disorder and positively correlated with serum nitrate

Contact Info

Product

Resources

About