Nitric Oxide Is Involved in the Response of the Isolated Intact and Epithelium-Denuded Rat Trachea to the β&lt;sub&gt;2&lt;/sub&gt; Adrenergic Receptor Agonist Salbutamol

Montalvo, Freddie W.; Cantres-Fonseca, O.; Santos, Gilson Gonçalves dos; Vega, Margarita; Torres, Iraci Lucena da Silva; Carmona, JU; Dexter, David T.; Santacana, G.

doi:10.1159/000319164

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…Recently, it was shown that salbutamol-induced relaxation in rat tracheas involves the relaxing action of NO [30]. …”

Section: Discussionmentioning

confidence: 99%

The Effect of NG-Nitro-L-Arginine Methyl Ester, a Nitric Oxide Synthase Inhibitor, on Respiratory Mechanics in Rats

Rubini

2011

Respiration

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Background: Data describing the inhibitory effects of nitric oxide synthase (NOS) on respiratory mechanics are conflicting, and no data are available concerning possible effects on the viscoelasticity of the respiratory system, on the inspiratory work of breathing (WOB) or on respiratory system hysteresis. Objectives: The aim of this study was to measure the effects of NOS inhibition by N^G-nitro-L-arginine methyl ester (L-NAME) on respiratory mechanics in normal anesthetized rats. Methods: Using the end-inflation occlusion method, it was possible to quantify the ohmic and viscoelastic airway resistance and elastance of the respiratory system. Ohmic resistance is the normalized-to-flow pressure dissipation due to viscous forces opposing the airflow in the airways, as predicted by the Poiseuille law. Viscoelastic resistance is the normalized-to-flow pressure dissipation due to the resistance of respiratory system tissue to deformation during inflation, which is recovered after the arrest of the inspiratory flow (stress relaxation). The inspiratory WOB, its elastic and resistive components, and hysteresis were also calculated. Results:L-NAME induced an increment in the ohmic airway resistance and in the resistive ohmic inspiratory WOB. The viscoelastic resistance due to stress relaxation and the elastic properties of the respiratory system were not modified, and no effect was detected on the related components of the inspiratory WOB and on hysteresis. Conclusions: NO acts in normal rats to reduce the ohmic component of airway resistance, decreasing the ohmic inspiratory WOB. The elastic and viscoelastic components are unaltered. Hysteresis is also unaltered, suggesting that NO has negligible effects on alveolar surfactant activity.

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“…Recently, it was shown that salbutamol-induced relaxation in rat tracheas involves the relaxing action of NO [30]. …”

Section: Discussionmentioning

confidence: 99%

The Effect of NG-Nitro-L-Arginine Methyl Ester, a Nitric Oxide Synthase Inhibitor, on Respiratory Mechanics in Rats

Rubini

2011

Respiration

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“…On the other hand, ENO may also be influenced by nondisease factors such as nitrate-containing foods [14], caffeine [15], alcohol [16], cigarette smoking [17], recent exercise [18], and some medications [19,20]. Due to these factors, ENO research protocols often incorporate more conventional measures of lung function, such as spirometric maneuvers (SPM), before and after bronchodilator administrations.…”

Section: Introductionmentioning

confidence: 99%

Spirometric Maneuvers and Inhaled Salbutamol Do Not Affect Exhaled Nitric Oxide Measurements among Patients with Allergic Asthma

Garriga

Labrador‐Horrillo²,

Guillén³

et al. 2011

Respiration

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Background: Exhaled nitric oxide (ENO) is used as a marker of airway inflammation. Factors such as spirometric maneuvers (SPM), β₂-agonists, or tobacco smoking have been postulated to affect ENO measurements. Guidelines on measurement techniques have been published based on expert opinions. Nevertheless, there is no strong clinical evidence of many aspects because they have not been supported by research data. Objectives: The aim of this study was to evaluate the influence of performing a spirometry or receiving inhaled salbutamol on ENO readings. Methods: One hundred forty-five adults and 62 children with allergic asthma were included with a mean age of 36 ± 13 years for adults and 13 ± 2 years for children. A control group comprised 30 healthy adults and 30 children with a mean age of 37 ± 14 years and 13 ± 2 years, respectively. ENO measurements were performed with a NIOX-MINO® electrochemical device. In 179 patients ENO was measured before and after performing SPM and in 88 patients before and 15 min after SPM plus 2 puffs of salbutamol (100 µg/puff). Results: There were no significant differences in mean ENO levels before and after SPM or before and after SPM plus 2 puffs of inhaled salbutamol in adults or children (asthmatic or healthy). Conclusions: Levels of ENO are not significantly affected by SPM or salbutamol inhalation.

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Potential mechanisms underlying the effects of lipid emulsion against theophylline-induced toxicity

Lee

Sohn

2021

The American Journal of Emergency Medicine

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Nitric Oxide Is Involved in the Response of the Isolated Intact and Epithelium-Denuded Rat Trachea to the β<sub>2</sub> Adrenergic Receptor Agonist Salbutamol

Cited by 5 publications

References 52 publications

The Effect of N<sup>G</sup>-Nitro-<i>L</i>-Arginine Methyl Ester, a Nitric Oxide Synthase Inhibitor, on Respiratory Mechanics in Rats

The Effect of N<sup>G</sup>-Nitro-<i>L</i>-Arginine Methyl Ester, a Nitric Oxide Synthase Inhibitor, on Respiratory Mechanics in Rats

Spirometric Maneuvers and Inhaled Salbutamol Do Not Affect Exhaled Nitric Oxide Measurements among Patients with Allergic Asthma

Potential mechanisms underlying the effects of lipid emulsion against theophylline-induced toxicity

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