Nitric oxide is induced and required for efficient Kaposi's sarcoma‐associated herpesvirus lytic replication

Herrera-Ortíz, Antonia; Meng, Wen; Gao, Shou‐Jiang

doi:10.1002/jmv.27228

Cited by 3 publications

(1 citation statement)

References 36 publications

(145 reference statements)

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“…Recently, nitric oxide (NO) also plays an important role in the development of sarcoma tumors. According to Herrera-Ortiz et al (3), NO inhibition resulted in a decrease in the infectious virus, lysogenic transcript, and protein. Proteins of the SARS-CoV-2 virus, namely the S and N proteins, cause tic reactivation and accelerate carcinogenesis.…”

Section: New Research Findings Have Shown Thatmentioning

confidence: 99%

Treatment of Skin Oncological Disease Using an Immunosuppressive Medication

Mikazans

2023

Gac Méd Caracas

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Skin cancer or non-melanoma malignant formations, as well as melanomas, are recorded in more than 2-3 million people every year. The most important cause of the occurrence of this disease is the effect of UV radiation on damaged areas of the skin, birthmarks, or sensitive skin (light, capable of burning). Dermatoscopy is one of the most important methods for determining the stage of tumor development, and the simplest method of treatment in the initial stages is the use of immunosuppressive agents that reduce the work of the immune system by preventing the formation of antibodies.

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Section: New Research Findings Have Shown Thatmentioning

confidence: 99%

Treatment of Skin Oncological Disease Using an Immunosuppressive Medication

Mikazans

2023

Gac Méd Caracas

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Elevated iNOS and 3′-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model

Vladimirova¹,

Soldan²,

Su³

et al. 2023

Tumour Virus Research

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Kaposi Sarcoma, a Trifecta of Pathogenic Mechanisms

et al. 2022

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Kaposi’s sarcoma is a rare disease with four known variants: classic, epidemic, endemic and iatrogenic (transplant-related), all caused by an oncogenic virus named Human Herpes Virus 8. The viral infection in itself, along with the oncogenic properties of HHV8 and with immune system dysfunction, forms the grounds on which Kaposi’s Sarcoma may develop. Infection with HHV8 occurs through saliva via close contacts, blood, blood products, solid organ donation and, rarely, vertical transmission. Chronic inflammation and oncogenesis are promoted by a mix of viral genes that directly promote cell survival and transformation or interfere with the regular cell cycle and cell signaling (of particular note: LANA-1, v-IL6, vBCL-2, vIAP, vIRF3, vGPCR, gB, K1, K8.1, K15). The most common development sites for Kaposi’s sarcoma are the skin, mucocutaneous zones, lymph nodes and visceral organs, but it can also rarely appear in the musculoskeletal system, urinary system, endocrine organs, heart or eye. Histopathologically, spindle cell proliferation with slit-like vascular spaces, plasma cell and lymphocyte infiltrate are characteristic. The clinical presentation is heterogenic depending on the variant; some patients have indolent disease and others have aggressive disease. The treatment options include highly active antiretroviral therapy, surgery, radiation therapy, chemotherapy, and immunotherapy. A literature search was carried out using the MEDLINE/PubMed, SCOPUS and Google Scholar databases with a combination of keywords with the aim to provide critical, concise, and comprehensive insights into advances in the pathogenic mechanism of Kaposi’s sarcoma.

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Nitric oxide is induced and required for efficient Kaposi's sarcoma‐associated herpesvirus lytic replication

Cited by 3 publications

References 36 publications

Treatment of Skin Oncological Disease Using an Immunosuppressive Medication

Treatment of Skin Oncological Disease Using an Immunosuppressive Medication

Elevated iNOS and 3′-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model

Kaposi Sarcoma, a Trifecta of Pathogenic Mechanisms

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