Nitric Oxide in Listeriosis

Boockvar, Kenneth S.; Maybodi, M; Poston, R M; Kurlander, R L; Granger, Donald L.

doi:10.1007/0-306-46816-6_22

Cited by 2 publications

(3 citation statements)

References 63 publications

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“…To test that hypothesis we inhibited NO synthesis in DBA/2 mice and then infected them with C. immitis 10 . We first showed that aminoguanidine (AMG) 14 in the drinking water reduced the urinary excretion nitrate (an excellent reflection of the amount of NO made by the mice 15 ) by infected DBA/2 mice. This in turn increased the severity of infection as measured by colony counts in the lungs and spleens, 14 days after i.p.…”

Section: Immune Responses Of Inbred Mice To C Immitis Infectionmentioning

confidence: 99%

“…These data are the composite of two separate experiments, and the total number of mice in each group is in parentheses. drinking water reduced the urinary excretion nitrate (an excellent reflection of the amount of NO made by the mice 15 ) by infected DBA/2 mice. This in turn increased the severity of infection as measured by colony counts in the lungs and spleens, 14 days after i.p.…”

Section: Immune Responses Of Inbred Mice To C Immitis Infectionmentioning

confidence: 99%

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The Role of IL‐10 in Genetic Susceptibility to Coccidioidomycosis on Mice

Fierer

2007

Annals of the New York Academy of Sciences

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Epidemiological and clinical studies have confirmed that coccidioidomycosis is more severe in African American and Filipino patients than in Caucasians, suggesting a genetic basis for susceptibility in humans. We discovered that inbred strains of mice also vary greatly in their susceptibility to Coccidioides immitis infections, and although resistance is the dominant phenotype, it is a multigenic trait in mice. We found a strong direct correlation between susceptibility in mice and the amount of IL-10 made in response to infection. We then showed that IL-10-deficient mice are much more resistant to infection than the parent C57BL/6 strain. Finally, we showed that genetically resistant mice that are transgenic for IL-10 and so overproduce that cytokine are more susceptible to C. immitis. This is in part due to suppression of NOS2 expression by IL-10.

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Section: Immune Responses Of Inbred Mice To C Immitis Infectionmentioning

confidence: 99%

Section: Immune Responses Of Inbred Mice To C Immitis Infectionmentioning

confidence: 99%

The Role of IL‐10 in Genetic Susceptibility to Coccidioidomycosis on Mice

Fierer

2007

Annals of the New York Academy of Sciences

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“…Knowledge of cytokine-induced NO · synthesis has not resulted in an equivalent increase in the understanding of how chronic infection with toxoplasma or besnoitia increases resistance to a vertically transmitted retrovirus-induced thymic lymphoma (figure 1) or to primary infection with Listeria (figure 2). It is clear that cytokine-induced high-output NO · synthesis and the NOS2 gene are contributory to host defense against primary Listeria infection [38,39]. We also can make the general statement that we are now aware that NOS2 is induced by cytokines when there are perturbations (e.g., microbial invasion, inflammation, mechanical damage) in the tissues that are a serious threat to stability and perhaps survival of the animal.…”

Section: Epiloguementioning

confidence: 99%

Infection and Nitric Oxide

Hibbs

2002

J INFECT DIS

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The author describes how his experience as an infectious disease fellow at Stanford University with Jack Remington from 1969 to 1971 influenced the direction of his subsequent laboratory investigation. The author reviews a series of studies that were intended to provide a mechanistic understanding of an in vitro cytotoxicity assay developed while he was a fellow with Jack Remington. These investigations resulted in the 1987 discovery of the synthesis of nitric oxide from L-arginine by cytokine-activated macrophages. This work provided the components (the precursor, products, and an inhibitor) of the enzymatic synthesis of nitric oxide by all three later-identified nitric oxide synthase isoforms. The significance of cytokine-induced nitric oxide synthesis during innate resistance and cell-mediated immune reactions is discussed briefly.

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Nitric Oxide in Listeriosis

Cited by 2 publications

References 63 publications

The Role of IL‐10 in Genetic Susceptibility to Coccidioidomycosis on Mice

The Role of IL‐10 in Genetic Susceptibility to Coccidioidomycosis on Mice

Infection and Nitric Oxide

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