Nitric oxide gas inhalation to prevent COVID-2019 in healthcare providers

Abstract

Introduction:In human hosts, SARS-CoV-2 causes a respiratory syndrome (named COVID-19) which

High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19)

“…2 ). 6 The nitric oxide mixture was delivered at a concentration between 160 and 200 ppm at the desired FiO 2 concentration. Nitrogen dioxide concentrations had been measured previously using the same breathing circuit and a test lung in the laboratory and were maintained at concentrations below 1.5 ppm.…”

Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections

“…NO inhaled treatment against COVID has already been proposed in 2020 in two different countries, China and United States of America ( Berra et al, 2020 ; Gianni et al, 2020a ; Lei et al, 2020 ). The motivation comes from the historical use of NO-based treatment against SARS-CoV, and also against other respiratory diseases caused by viruses.…”

“…Thus, the protocols published to date against SARS-CoV-2 rely on the efficient results previously demonstrated. Three different strategies were proposed to comprehend the treatment under different conditions, using a randomized experiment evolving 2 centers: Boston and Xi’an ( Berra et al, 2020 ; Gianni et al, 2020a ; Lei et al, 2020 ). Firstly, NO application in severely ill patients is proposed in two different conditions: (i) high doses of gaseous NO, up to 180 ppm, during short periods of time (20-30 min), and (ii) low doses of gaseous NO, up to 80 ppm, during 48 h-treatment ( Berra et al, 2020 ; Lei et al, 2020 ).…”

“…Firstly, NO application in severely ill patients is proposed in two different conditions: (i) high doses of gaseous NO, up to 180 ppm, during short periods of time (20-30 min), and (ii) low doses of gaseous NO, up to 80 ppm, during 48 h-treatment ( Berra et al, 2020 ; Lei et al, 2020 ). Interestingly, a second protocol proposed inhaled NO to prevent COVID-19 in healthcare providers who are in direct contact with patients infected with SARS-CoV-2 ( Gianni et al, 2020a ). The individuals concerned will receive a maximum of 160 ppm of inhaled NO for a short period of time during 14 days.…”

“…Therefore, a rush in the study and development of possible treatments and vaccines has been observed from numerous scientists using different approaches ( Martinez, 2020 ). A promising strategy under consideration is the use of inhalation-based therapies, including inhaled nitric oxide (NO) ( Gianni et al, 2020a ). This short communication aims to highlight important impacts of NO application, reporting the effectiveness of NO against coronaviruses, including SARS-CoV-2, and evidencing promising strategies to leverage this research field.…”