Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Workie, Yitayal Admassu; Sabrina,; Imae, Toyoko; Krafft, Marie Pierre

doi:10.1021/acsbiomaterials.9b00474

Cited by 16 publications

(29 citation statements)

References 45 publications

(83 reference statements)

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“…GO-PEG-Ag damaged the bacterial structure causing leakage of cytoplasmic components, decrease of metabolic activity, and the generation of ROS ( Figure 5D). Recently, Workie et al 65 delivered nitric oxide (NO) using fluorinated PEG@GO carrier and found more effective antibacterial activity for NO-conserved F-PEG@GO than NO-conserved GO. The hydrophobic perfluorocarbon moiety on F-PEG@GO conserved more NO than GO resulting in superior activity.…”

Section: Antibacterial Efficacymentioning

confidence: 99%

<p>Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances</p>

Ghosh¹,

Chatterjee²

2020

IJN

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Owing to the unique physical, chemical, mechanical and electrical properties, graphene and its derivatives have been extensively researched for diverse biomedical applications including in tissue engineering since the past decade. Tunable chemical functionalities of graphene oxide (GO), a graphene derivative, allow easy surface functionalization. Functionalization of GO with poly(ethylene glycol) (PEG) (PEG-GO) has received significant attention as it offers superior solubility, stability, and biocompatibility. Besides being an attractive candidate for drug delivery, PEG-GO can aid in the attachment, proliferation, and differentiation of stem cells, thereby augmenting tissue engineering. PEG-GO has shown excellent antibacterial efficacy, which could be an added advantage to minimize implantassociated infections. This review describes the synthesis techniques, properties, and biological potential of PEG-GO towards mammalian and bacterial cells. Studies wherein these nanomaterials have been explored for engineering various tissues are reviewed along with future opportunities in this field.

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Section: Antibacterial Efficacymentioning

confidence: 99%

<p>Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances</p>

Ghosh¹,

Chatterjee²

2020

IJN

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“…The generated gas was introduced into a vessel placing the gas carrier materials in a closed system, following the reaction of 3Cu + 8HNO 3 → 3Cu(NO 3 ) 2 + 2NO + 4H 2 O. The quantitative determination of NO gas in the carrier materials at a given time after stopping the loading was achieved following the previously reported method by a Griess assay method . The obtained quantity indicates NO gas in the carrier at a certain time after being loaded.…”

Section: Methodsmentioning

confidence: 99%

“…Gram-negative Escherichia coli ( E. coli ) and Gram-positive Staphylococcus aureus ( S. aureus ) were the strains used for the antimicrobial test based on the standard agar disk-diffusion method . The suspension (100 μL) of bacteria grown in the agar medium (Luria–Bertani for E.…”

Section: Methodsmentioning

confidence: 99%

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Nitric Oxide Gas in Carbon Nanohorn/Fluorinated Dendrimer/Fluorinated Poly(ethylene glycol)-Based Hierarchical Nanocomposites as Therapeutic Nanocarriers

Krathumkhet

Sabrina

Imae

et al. 2021

ACS Appl. Bio Mater.

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Nitric oxide (NO) gas nanocarrier materials were prepared via a hierarchical assembly of poly(amido amine) dendrimers with fluorocarbon binding sites (DEN-F) and fluorinated poly(ethylene glycol) (F-PEG) on nitrogen-doped carbon nanohorns (NCNHs). The loading abilities of NO gas in these nanocarrier materials increased with the nitrogen doping of CNH and hierarchies formed by DEN-F and F-PEG. Especially, the ability of CNH-based nanocomposite materials was better than that of graphene-based materials. The loading of NO gas arose an infrared absorption band at 1387 cm–1 and increased the intensity ratio of D and G bands in Raman spectra, although these phenomena diminished after the degas treatment. The antimicrobial effects on bacteria (Escherichia coli and Staphylococcus aureus) increased depending on the loading amount of NO gas. It was confirmed from these results that NO gas weakly interacts with nitrogen-doped CNH and is trapped in the void volumes of DEN-F and F-PEG hierarchies. Thus, the concentric hierarchy is preferable for slow release of NO gas due to the void volumes in DEN-F, F-PEG, and CNH hierarchical organization. This sustained release of NO gas is advantageous with regards to the potential biomedical gas therapy against bacteria and other parasites.

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“…The combination of NO therapy with 2D nanomaterials has been explored, which showed great potential for treating cancer in the clinic. [ 151,438,439 ]…”

Section: Nir‐ii Ptt For Cancermentioning

confidence: 99%

NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges

Zhang

et al. 2021

Adv Funct Materials

155

102

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Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional cancer treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 nm) with less energy dissipation has been developed for deeper‐seated tumor treatment in recent years compared with the traditional first near‐infrared light (750–1000 nm). In addition, the use of emerging inorganic 2D nanomaterials as photothermal agents (PTAs) further enhanced PTT efficiency due to their intrinsic photothermal properties. NIR‐II light stimulated inorganic 2D nanomaterials for PTT is becoming a hot topic in both academic and clinical fields. This review summarizes the categories, structures, and photothermal conversion properties of inorganic 2D nanomaterials for the first time. The recent synergistic strategies of NIR‐II responsive PTT combined with other treatment approaches including chemotherapy, chemodynamic therapy, photodynamic therapy, radiotherapy are summarized. The future challenges and perspectives on these 2D nanomaterials for NIR‐II responsive PTT systems construction are further discussed.

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Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Cited by 16 publications

References 45 publications

<p>Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances</p>

<p>Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances</p>

Nitric Oxide Gas in Carbon Nanohorn/Fluorinated Dendrimer/Fluorinated Poly(ethylene glycol)-Based Hierarchical Nanocomposites as Therapeutic Nanocarriers

NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges

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