Nitric oxide for respiratory failure in infants born at or near term

Nn, Finer; Barrington, KJ

doi:10.1002/14651858.cd000399

Cited by 103 publications

(107 citation statements)

References 52 publications

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“…HRF is a fairly common problem in the term infants and is multifactorial in etiology associated with conditions such as PPHN, meconium aspiration, respiratory distress syndrome, perinatal asphyxia and sepsis 1 – 4. We recently reported a significant association between occult placental inflammation and HRF secondary to PPHN 15. The findings in this study are consistent with our prior observations.…”

Section: Discussionsupporting

confidence: 92%

“…Histological evidence of placental inflammation was associated with a greater but non-significant need for iNO. Interestingly, when the data from our prior observations15 are combined with the current data, the presence of placental inflammation is associated with a 3.5-fold increased likelihood of receiving iNO treatment as opposed to cases of HRF where there is no inflammation (95% CI 1.1 to 11).…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein

Woldesenbet¹,

Rosenfeld

Ramilo

et al. 2008

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 52%

Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein

Woldesenbet¹,

Rosenfeld

Ramilo

et al. 2008

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…21,22 For premature NBs, a met-analysis of three randomized, controlled studies did not demonstrate that the gas had any effect on mortality or on the appearance of bronchopulmonary dysplasia. Only one of the studies analyzed demonstrated reductions in the number of days of mechanical ventilation use in the group treated with iNO.…”

Section: Persistent Pulmonary Hypertension and Hypoxemic Respiratory mentioning

confidence: 99%

Uso do óxido nítrico em pediatria

Fioretto¹

2003

J. Pediatr. (Rio J.)

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Objective: To review the literature on inhaled nitric oxide and to describe its main clinical applications in pediatrics. Sources of data:A 10 year literature review with selection of the most important publications on inhaled nitric oxide, using the Medline and Cochrane Systematic Review databases. Summary of the findings:This review was organized as follows: introduction; metabolism and biological effects; clinical applications; dosage, gas administration and weaning; precautions and sideeffects. Inhaled nitric oxide use was described in persistent pulmonary hypertension and hypoxia of the newborn, acute respiratory distress syndrome, primary pulmonary hypertension, heart surgery, chronic obstructive pulmonary disease, sickle cell anemia, and bronchospastic disease. Conclusions:Inhaled nitric oxide is a therapeutic approach with wide clinical applications in pediatrics. Its use is safe when administered in pediatric intensive care units under strict monitoring. As a pulmonary vasodilator, nitric oxide has beneficial effects on gas exchange and ventilation. Controlled trials, focusing on early gas administration should be performed under many clinical conditions, especially acute respiratory distress syndrome.J Pediatr (Rio J) 2003;79(Suppl 2):S177-S186: Inhaled nitric oxide, pediatrics, pulmonary hypertension, mechanical ventilation.

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“…iNO is easily available, effective and safe (although not cheap). Its biological basis is established 6. In hypoxaemic term and near term infants, oxygenation improves in about 50% of babies who are given iNO.…”

Section: Practicementioning

confidence: 99%

How has research in the last 5 years changed my clinical practice?

Weindling

2009

Archives of Disease in Childhood - Fetal and Neonatal Edition

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This paper considers some of the changes in practice that have occurred in the last 5 years. There have been significant improvements in parental involvement in care. Not all changes have been based on evidence from research: practice has also been affected by changing technology and pressure by industry and other groups. Among the research-based changes were: an awareness of confidentiality, individualised developmental care, increased use of inhaled nitric oxide, therapeutic hypothermia, less postnatal steroids (although the dosage used is not evidence-based), sucrose as analgesia and permissive hypotension.

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Nitric oxide for respiratory failure in infants born at or near term

Cited by 103 publications

References 52 publications

Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein

Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein

Uso do óxido nítrico em pediatria

How has research in the last 5 years changed my clinical practice?

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