Nitric oxide donors for treating preterm labour

Duckitt, Kirsten; Thornton, Steve; O'Donovan, Oliver; Dowswell, Therese

doi:10.1002/14651858.cd002860.pub2

Cited by 40 publications

(28 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, there is insufficient evidence to support the use of nitric oxide donors for prevention of PTB in women presenting with true preterm labor. 49…”

Section: Nitric Oxide Donorsmentioning

confidence: 99%

Tocolysis for Acute Preterm Labor: Where Have We Been, Where Are We Now, and Where are We Going?

Navathe

Berghella

2016

Amer J Perinatol

View full text Add to dashboard Cite

Tocolytics have been used for over 60 years for women with preterm labor, which ultimately can lead to preterm birth (PTB). Diagnosing preterm labor is challenging, but use of objective tests such as transvaginal ultrasound of cervical length assists in the identification of women at the highest risk for PTB. Once preterm labor has been diagnosed, clinicians can choose from a variety of drug classes (cyclooxygenase inhibitors, calcium channel blockers, and betamimetics) to achieve the primary goal of delaying delivery by 48 hours, thereby allowing time for administration of corticosteroids for fetal lung maturity, and if appropriate, starting magnesium sulfate for fetal neuroprotection. Cyclooxygenase inhibitors are the only class of tocolytics proven to decrease PTB < 37 weeks. Knowledge of the safety and effectiveness of these medications is paramount. Several additional agents (e.g., oxytocin receptor antagonists) have significant promise, but further studies are required before these medications can be approved for tocolysis in the United States. As we look into the future of tocolysis, we anticipate that deeper understanding of the complex physiology of preterm labor will allow us to uniquely target different etiologies that lead to the final path resulting in spontaneous preterm delivery.

show abstract

“…Currently, there is insufficient evidence to support the use of nitric oxide donors for prevention of PTB in women presenting with true preterm labor. 49…”

Section: Nitric Oxide Donorsmentioning

confidence: 99%

Tocolysis for Acute Preterm Labor: Where Have We Been, Where Are We Now, and Where are We Going?

Navathe

Berghella

2016

Amer J Perinatol

View full text Add to dashboard Cite

show abstract

“…[2][3][4][5][6][7] The decision as to which tocolytic agent should be used as first-line therapy for an individual patient should be based on multiple factors, including efficacy, gestational age, presence of maternal comorbidities, and the frequency and severity of side effects.…”

Section: Tocolyticsmentioning

confidence: 99%

“…Data from Refs. [2][3][4][5][6][7] Obstetric Interventions in Preterm Labor Abbreviations: IVH, intraventricular hemorrhage; NICU, neonatal intensive care unit; RDS, respiratory distress syndrome; RR, relative risk. Data from Refs.…”

Section: Tocolyticsmentioning

confidence: 99%

See 1 more Smart Citation

Preterm Labor

Locatelli

Consonni

Ghidini

2015

Obstetrics and Gynecology Clinics of North America

View full text Add to dashboard Cite

“…The clinical burden of preterm birth is substantial; 7.4% of infants are born before 37 weeks' gestation and 57% of neonatal deaths are attributed to preterm birth and its consequences. Knowledge of multiple clinical risk factors is insufficient to predict preterm labor accurately and enable prophylactic interventions, such as antenatal steroids, progesterone, cerclage and in‐utero transfer, to be targeted efficiently. Hospitalization is justified only in patients deemed at high risk of imminent delivery and poor outcome.…”

Section: Introductionmentioning

confidence: 99%

Ability of a preterm surveillance clinic to triage risk of preterm birth: a prospective cohort study

Min

Watson

Hezelgrave

et al. 2016

Ultrasound Obstet Gynecol

View full text Add to dashboard Cite

show abstract

Nitric oxide donors for treating preterm labour

Abstract: Smith G. Canadian preterm labour nitroglycerin trial. Personal communication 2002. Smith G. The Canadian preterm labour nitroglycerin trial. Current Controlled Trials (www.controlled-trials.com/mrct) (accessed 2005).

Cited by 40 publications

References 28 publications

Tocolysis for Acute Preterm Labor: Where Have We Been, Where Are We Now, and Where are We Going?

Tocolysis for Acute Preterm Labor: Where Have We Been, Where Are We Now, and Where are We Going?

Preterm Labor

Ability of a preterm surveillance clinic to triage risk of preterm birth: a prospective cohort study

Contact Info

Product

Resources

About