Nitric Oxide Donors as Potential Antitumor Agents

Корман, Д. Б.; Ostrovskaya, L. A.; Vanin, Anatoly F.

doi:10.1134/s000635092102010x

Cited by 4 publications

(1 citation statement)

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“…Hybridization concept is highly compelling for the exploitation of novel anticancer agents since hybrid molecules could simultaneously modulate multiple targets involved in cancer cell proliferation, thus enhancing the anticancer activity, circumventing the drug resistance, improving pharmacological profiles, and overcoming the severe side effects associated with a single drug molecule [15]. Accordingly, combination of furoxan with other anticancer pharmacophores seems an effective strategy to develop novel candidates against the drug-sensitive and drug-resistant cancers [16]. This review is to highlight the current scenario of furoxan hybrids with anticancer potency from 2012 to present.…”

Section: Introductionmentioning

confidence: 99%

The current scenario of furoxan hybrids with anticancer potential

Shi

Wang

Yan³

2023

Journal of Heterocyclic Chem

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Cancer is one of the most common and deadliest diseases affecting millions of human beings globally. Treatment of cancer has achieved great advancements, and chemotherapy remains one of the most important means. However, the chemotherapy suffers from apparent limitations including drug resistance, systemic toxicity, adverse effects, and tumor recurrence, creating an urgent demand to develop novel anticancer chemotherapeutics. Furoxan derivatives could exert anticancer activity via releasing high concentrations of nitric oxide (NO), which could induce cellular apoptosis, arrest cell cycle, inhibit the migration and invasion of cells, and suppress angiogenesis. Hence, furoxan derivatives demonstrated potent in vitro and in vivo anticancer efficiency. In particular, furoxan hybrids, combination of other anticancer pharmacophores with furoxan moiety, demonstrated significant therapeutic effects on various cancers including drug‐resistant forms since these derivatives could act on multiple targets in cancer cells simultaneously. Accordingly, furoxan hybrids constitute an important source in the development of novel chemotherapeutic agents with anticancer activity. This review is to highlight the current scenario of furoxan hybrids with anticancer potential, covering articles published from 2012 to present. The structure–activity relationships and mechanisms of action are discussed to continuously open up a map for the remarkable exploration of more effective candidates.

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Section: Introductionmentioning

confidence: 99%