Nitric Oxide Donors and Penile Erectile Function

Gür, Serap; Chen, Allen L.; Kadowitz, Philip J.

doi:10.1016/b978-0-12-809275-0.00005-3

Cited by 3 publications

(2 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NO release is accompan by the formation of a disulfide, which is formed by the reaction between two thiyl radic (RS•) [73]. The molecular structure of S-nitrosothiols influences the decomposition r Primary and secondary RSNOs are less stable, and thus exhibit a higher NO release r Moreover, these molecules can transfer the NO moiety to thiols without releasing NO a reaction termed trans-nitrosation [74,75], which in turn translates into a decrea possibility of generating peroxynitrite [48,75]. Due to this property, RSNOs have b linked to greater antibacterial activity as the result of nitrosylation of thiolated prote [58].…”

Section: S-nitrosothiolmentioning

confidence: 99%

“…Primary and secondary RSNOs are less stable, and thus exhibit a higher NO release rate. Moreover, these molecules can transfer the NO moiety to thiols without releasing NO, in a reaction termed trans-nitrosation [ 74 , 75 ], which in turn translates into a decreased possibility of generating peroxynitrite [ 48 , 75 ]. Due to this property, RSNOs have been linked to greater antibacterial activity as the result of nitrosylation of thiolated proteins [ 58 ].…”

Section: Nitric Oxide and Its Donorsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications

2022

View full text Add to dashboard Cite

Despite the noticeable evolution in wound treatment over the centuries, a functional material that promotes correct and swift wound healing is important, considering the relative weight of chronic wounds in healthcare. Difficult to heal in a fashionable time, chronic wounds are more prone to infections and complications thereof. Nitric oxide (NO) has been explored for wound healing applications due to its appealing properties, which in the wound healing context include vasodilation, angiogenesis promotion, cell proliferation, and antimicrobial activity. NO delivery is facilitated by molecules that release NO when prompted, whose stability is ensured using carriers. Hydrogels, popular materials for wound dressings, have been studied as scaffolds for NO storage and delivery, showing promising results such as enhanced wound healing, controlled and sustained NO release, and bactericidal properties. Systems reported so far regarding NO delivery by hydrogels are reviewed.

show abstract