Nitric oxide density distributions in the effluent of an RF argon APPJ: effect of gas flow rate and substrate

Iséni, Sylvain; Zhang, S Shiqiang; Gessel, van Afh Bram; Hofmann, Sven; Ham, van Btj; Reuter, Stephan; Weltmann, K.‐D.; Bruggeman, Peter

doi:10.1088/1367-2630/16/12/123011

Cited by 62 publications

(59 citation statements)

References 49 publications

(80 reference statements)

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“…At a gas flow rate of 3 slm and a corresponding Reynolds number of ≈ Re 3000 the flow is expected to be fully turbulent. The computed ambient species densities agree well with mass spectrometric measurements [38][39][40].…”

Section: Model Descriptionsupporting

confidence: 71%

Numerical analysis of the effect of nitrogen and oxygen admixtures on the chemistry of an argon plasma jet operating at atmospheric pressure

et al. 2015

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In this paper we study the cold atmospheric pressure plasma jet, called kinpen, operating in Ar with different admixture fractions up to 1% pure N 2 , O 2 and N 2 + O 2 . Moreover, the device is operating with a gas curtain of dry air. The absolute net production rates of the biologically active ozone (O 3 ) and nitrogen dioxide (NO 2 ) species are measured in the far effluent by quantum cascade laser absorption spectroscopy in the mid-infrared. Additionally, a zero-dimensional semi-empirical reaction kinetics model is used to calculate the net production rates of these reactive molecules, which are compared to the experimental data. The latter model is applied throughout the entire plasma jet, starting already within the device itself. Very good qualitative and even quantitative agreement between the calculated and measured data is demonstrated. The numerical model thus yields very useful information about the chemical pathways of both the O 3 and the NO 2 generation. It is shown that the production of these species can be manipulated by up to one order of magnitude by varying the amount of admixture or the admixture type, since this affects the electron kinetics significantly at these low concentration levels.− ONOO ) and protons [17]. Although the exact ratio between the different NO x and their reactivity depends on the pH of the biological sample, they generally cause oxidative reactions and are therefore highly bactericidal. The latter is also valid

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Section: Model Descriptionsupporting

confidence: 71%

Numerical analysis of the effect of nitrogen and oxygen admixtures on the chemistry of an argon plasma jet operating at atmospheric pressure

et al. 2015

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“…For the kINPen plasma jet, this includes for example nitrite, nitrate, hydrogen peroxide, superoxide, hydroxyl radical, peroxynitrite, and singlet oxygen [72][73][74]. Plasma gas phase analysis suggests the presence of many others [75][76][77]. Yet, if organic target molecules and/or cells are not present at the site of species creation or deposition, short- lived species yield more stable products such as hydrogen peroxide or hypochlorous acid [73].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Floating-Electrode DBD and kINPen Jet: Plasma Parameters to Achieve Similar Growth Reduction in Colon Cancer Cells Under Standardized Conditions

Bekeschus

Lin

Fridman

et al. 2017

Plasma Chem Plasma Process

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A comparative study of two plasma sources (floating-electrode dielectric barrier discharge, DBD, Drexel University; atmospheric pressure argon plasma jet, kINPen, INP Greifswald) on cancer cell toxicity was performed. Cell culture protocols, cytotoxicity assays, and procedures for assessment of hydrogen peroxide (H 2 O 2 ) were standardized between both labs. The inhibitory concentration 50 (IC50) and its corresponding H 2 O 2 deposition was determined for both devices. For the DBD, IC50 and H 2 O 2 generation were largely dependent on the total energy input but not pulsing frequency, treatment time, or total number of cells. DBD cytotoxicity could not be replicated by addition of H 2 O 2 alone and was inhibited by larger amounts of liquid present during the treatment. Jet plasma toxicity depended on peroxide generation as well as total cell number and amount of liquid. Thus, the amount of liquid present during plasma treatment in vitro is key in attenuating short-lived species or other physical effects from plasmas. These in vitro results suggest a role of liquids in or on tissues during plasma treatment in a clinical setting. Additionally, we provide a platform for correlation between different plasma sources for a predefined cellular response.

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“…[9][10][11][12][13] It is a streamerlike propagation that produces reactive species while it propagates in an ambient air. [16][17][18][19][20][21][22][23][24] For instance, although it is known that the discharge polarity affects the shape, length, and emission profile of the plasma jet, 25 few studies have reported its effect on the reactive species production. 14,15 Although many studies have measured reactive species in the plasma jet, a lot of things are still ambiguous about the relation between the plasma bullet propagation and the production of reactive species.…”

Section: Introductionmentioning

confidence: 99%

Effect of discharge polarity on the propagation of atmospheric-pressure helium plasma jets and the densities of OH, NO, and O radicals

Yonemori

Ono

2015

Biointerphases

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The atmospheric-pressure helium plasma jet is an emerging technology for plasma biomedical applications. In this paper, the authors focus on the effect of discharge polarity on propagation of the discharge and the densities of OH, NO, and O radicals. The plasma jet is applied to a glass surface placed on a grounded metal plate. Positive or negative voltage pulses with 25 μs duration, 8 kV amplitude, and 10 kpps repetition rate are used for the plasma jet. The plasma propagation is measured using a short-gated ICCD camera. The light emission intensity of the discharge generated at the rising phase of the voltage pulse is approximately equivalent for both polarities, while that generated during the falling phase is much higher for the negative discharge than the positive one. The shape of the discharge changes with the discharge polarity. The OH, NO, and O densities in the plasma jet are also measured for both polarities. It is found that the OH density is almost the same regardless the discharge polarity. Conversely, the negative discharge produces more O atoms and the positive discharge produces more NO molecules. These results indicate that the polarity of the discharge affects the densities of some reactive species produced in the plasma jet.

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Nitric oxide density distributions in the effluent of an RF argon APPJ: effect of gas flow rate and substrate

Cited by 62 publications

References 49 publications

Numerical analysis of the effect of nitrogen and oxygen admixtures on the chemistry of an argon plasma jet operating at atmospheric pressure

Numerical analysis of the effect of nitrogen and oxygen admixtures on the chemistry of an argon plasma jet operating at atmospheric pressure

A Comparison of Floating-Electrode DBD and kINPen Jet: Plasma Parameters to Achieve Similar Growth Reduction in Colon Cancer Cells Under Standardized Conditions

Effect of discharge polarity on the propagation of atmospheric-pressure helium plasma jets and the densities of OH, NO, and O radicals

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