Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis

Staykova, Maria; Fordham, Susan A.; Bartell, G.; Cowden, W. B.; Willenborg, David O.

doi:10.1016/j.jneuroim.2006.03.015

Cited by 12 publications

(5 citation statements)

References 31 publications

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“…This is consistent with the findings of Staykova et al . (9) who reported that compared to T cells from older SJL/J males, T cells from young SJL/J male make significantly more IFNγ.…”

Section: Resultsmentioning

confidence: 99%

Cutting Edge: The Y Chromosome Controls the Age-Dependent Experimental Allergic Encephalomyelitis Sexual Dimorphism in SJL/J Mice

Spach¹,

Blake²,

Bunn³

et al. 2009

The Journal of Immunology

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Multiple sclerosis is a sexually dimorphic, demyelinating disease of the CNS, and experimental allergic encephalomyelitis (EAE) is its principal autoimmune model. Young male SJL/J mice are relatively resistant to EAE whereas older males and SJL/J females of any age are susceptible. By comparing a wide age range of proteolipid protein peptide 139 -151 immunized mice, we found that female disease severity remains constant with age. In contrast, EAE disease severity increases with age in SJL/J males, with young males having significantly less severe disease and older males having significantly more disease than equivalently aged females. M ultiple sclerosis (MS)3 is a chronic, demyelinating disease of the CNS that results in substantial disability and paralysis. Although MS prevalence is ϳ3-fold higher in women than in men, MS in men is characterized by a more rapid clinical course and typically presents as severe progressive disease (1). Interestingly, the female-biased sexual dimorphism has been found to be on the rise within the past 50 years, presumably due to gene-environment interactions (2, 3).Experimental allergic encephalomyelitis (EAE) is the principal autoimmune model of MS. EAE in the inbred SJL/J mouse strain has been used as a model of the sexual dimorphism seen in MS, as SJL/J females are considered more susceptible to EAE than males. However, this gender bias in the EAE sexual dimorphism of SJL/J mice is unique in that it is age dependent, reflecting changes in EAE susceptibility of male mice, not female mice. Compared with young female SJL/J mice, young (4 -8 wk) male SJL/J mice show significantly impaired delayed type hypersensitivity responses (4, 5) and are significantly less susceptible to EAE (6 -10). In contrast, EAE susceptibility in older (Ն12 wk) SJL/J males is equivalent to that seen in 6-wk-old SJL/J females (6). Consequently, this gives rise to a female-biased EAE sexual dimorphism when female mice of any age are compared only with young (4 -8 wk) males. Both gonadal hormones (11-14) and sex chromosome (Chr) effects (15, 16) have been postulated to cause the sexual dimorphism. In young SJL/J mice, male gonadal hormones (12, 17) have been implicated in EAE resistance because castration of young SJL/J mice significantly increases EAE incidence and severity (6, 14) and induces the female predominant relapsing-remitting form of the disease (12, 17). Collectively, these published reports show that the gender bias of the EAE sexual dimorphism in SJL/J mice is a function of a testes-dependent, age-related transition in the EAE susceptibility of SJL/J males and is not due to an inherent steady-state increase in the EAE susceptibility of female SJL/J mice.Using C57BL/6J Y Chr substitution strains (consomic mice), we previously demonstrated that a gene or genes on the Y Chr, termed Yeae, influence EAE (18). This was the first experimental evidence demonstrating the existence of a Y Chr polymorphism capable of modifying EAE susceptibility. Because the age-dependent change in EAE susceptibility of...

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“…This is consistent with the findings of Staykova et al . (9) who reported that compared to T cells from older SJL/J males, T cells from young SJL/J male make significantly more IFNγ.…”

Section: Resultsmentioning

confidence: 99%

Cutting Edge: The Y Chromosome Controls the Age-Dependent Experimental Allergic Encephalomyelitis Sexual Dimorphism in SJL/J Mice

Spach¹,

Blake²,

Bunn³

et al. 2009

The Journal of Immunology

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“…The mechanisms for this are not totally understood, but studies have shown a TH 1 bias in females as opposed to a TH 2 bias in males Bebo, Schuster, Vandenbark, & Offner, 1999). Other studies have suggested roles for nitric oxide (Staykova et al, 2006) or sphingosine-1phosphate receptor 2 (Cruz-Orengo et al, 2014). In particular, the higher expression of the sphingosine receptor in females might be involved with disruption of the blood brain barrier (Cruz-Orengo et al, 2014).…”

Section: Effect Of Cannabinoid Compounds In Active Eae Using the Sjl mentioning

confidence: 98%

“…11.25.2), which closely mimics the predominant form of human MS. It is important to note that active (and passive) EAE in SJL mice is sex-and age-dependent; female mice are susceptible to relapsing-remitting EAE at all ages, while young male mice (i.e., ࣘ 6 weeks) are resistant, but become more susceptible to disease with age Bebo, Schuster, Vandenbark, & Offner, 1998;Bebo, Vandenbark, & Offner, 1996;Cruz-Orengo et al, 2014;Fillmore, Blankenhorn, Zachary, & Teuscher, 2004;Staykova, Fordham, Bartell, Cowden, & Willenborg, 2006). The mechanisms for this are not totally understood, but studies have shown a TH 1 bias in females as opposed to a TH 2 bias in males Bebo, Schuster, Vandenbark, & Offner, 1999).…”

Section: Effect Of Cannabinoid Compounds In Active Eae Using the Sjl mentioning

confidence: 99%

Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis

Kaplan

2018

CP Toxicology

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Cannabinoid compounds refer to a group of more than 60 plant-derived compounds in Cannabis sativa, more commonly known as marijuana. Exposure to marijuana and cannabinoid compounds has been increasing due to increased societal acceptance for both recreational and possible medical use. Cannabinoid compounds suppress immune function, and while this could compromise one's ability to fight infections, immune suppression is the desired effect for therapies for autoimmune diseases. It is critical, therefore, to understand the effects and mechanisms by which cannabinoid compounds alter immune function, especially immune responses induced in autoimmune disease. Therefore, this unit will describe induction and assessment of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), and its potential alteration by cannabinoid compounds. The unit includes three approaches to induce EAE, two of which provide correlations to two forms of MS, and the third specifically addresses the role of autoreactive T cells in EAE. © 2018 by John Wiley & Sons, Inc.

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“…An important aspect of the pathogenesis of EAE, with potential for therapeutic manipulation, is the role of ROS in the inflammatory process [70]. Thus, a scavenger of ROS is expected to prevent this free radical-mediated EAE.…”

Section: Sesame Oilmentioning

confidence: 99%

Beneficial Effects of Plant Oils Supplementation on Multiple Sclerosis: A Comprehensive Review of Clinical and Experimental Studies

Al-Naqeb,

Kalmpourtzidou,

De Giuseppe

et al. 2023

Nutrients

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Multiple sclerosis disease (MS) is a 38.5 chronic neurological autoimmune disease that affects the nervous system, and its incidence is increasing globally. At present, there is no cure for this disease, and with its severity and disabling variety, it is important to search for possibilities that could help to slow its progression. It is recognized that the mechanisms of MS pathology, its development and degree of activity can be affected by dietary factors. In this review, the beneficial health effects of 10 plants oils—mainly seed oils, including pomegranate seed oil, sesame oil, acer truncatum bunge seed oil, hemp seeds oil, evening primrose seed oil, coconut oil, walnut oil, essential oil from Pterodon emarginatus seeds, flaxseed oil and olive oil—on MS are discussed. The literature data indicate that plant oils could be effective for the treatment of MS and its related symptoms primarily through reducing inflammation, promoting remyelination, immunomodulation and inhibiting oxidative stress. Plant oils may potentially reduce MS progression. Longitudinal research including a larger sample size with a longer duration is essential to confirm the findings from the selected plant oils. Moreover, new plant oils should be studied for their potential MS benefit.

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Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis

Cited by 12 publications

References 31 publications

Cutting Edge: The Y Chromosome Controls the Age-Dependent Experimental Allergic Encephalomyelitis Sexual Dimorphism in SJL/J Mice

Cutting Edge: The Y Chromosome Controls the Age-Dependent Experimental Allergic Encephalomyelitis Sexual Dimorphism in SJL/J Mice

Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis

Beneficial Effects of Plant Oils Supplementation on Multiple Sclerosis: A Comprehensive Review of Clinical and Experimental Studies

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