Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

Lyall, Fiona; Greer, I. A.; Young, Anne; Myatt, Leslie

doi:10.1016/s0143-4004(96)80009-9

Cited by 107 publications

(56 citation statements)

References 27 publications

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“…28,29 On the other hand, other authors have found that concentrations of plasma nitrates and nitrites are higher in the fetal circulation of growth-restriction pregnancies in comparison with normal pregnancies. 30,31 The reasons for these apparent discrepant results are currently not known, but our study is the first to investigate NO levels in SGA children, suggesting that alterations to NO pathways could contribute to adult disease. The finding of an inverse correlation between NO and serum uric acid levels is also relevant.…”

Section: Discussionmentioning

confidence: 82%

Homocysteine and Nitric Oxide Are Related to Blood Pressure and Vascular Function in Small-for-Gestational-Age Children

et al. 2007

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Abstract-Leptin, homocysteine (Hcy), and C-reactive protein are risk factors potentially useful in predicting future cardiac events. These plasma biomarkers may participate in the regulation of cardiovascular function through an NO-dependent mechanism. Our purpose was to investigate whether alterations in C-reactive protein, Hcy, leptin, and NO are present in small-for-gestational-age children and to determine whether the levels of these plasma biomarkers are associated with birth weight, vascular function, and blood pressure. Concentrations of leptin, Hcy, C-reactive protein, and NO were measured in 69 children (36 boys and 33 girls; ages 8 to 13 years). Leptin (means difference: 1.4 ng/mL; 95% CI: 0.4 to 2.4) and Hcy (means difference: 0.9 mol/L; 95% CI: 0.3 to 1.5) levels were significantly elevated in children born small for gestational age compared with those with appropriate birth weight. Nevertheless, NO (means difference: 342.9 mol; 95% CI: 124.2 to 561.6) concentration was significantly reduced in small birth weight children, and the levels of C-reactive protein remained unchanged. There was a significant association between the circulating levels of both NO and Hcy with vascular function, as well as with blood pressure levels, in our population. Because both Hcy and NO are associated with a risk of cardiovascular disease, it is possible that part of the association of low birth weight with elevated risk for vascular and metabolic disease in later life is mediated by perturbation in pathways for these biomarkers.

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Section: Discussionmentioning

confidence: 82%

Homocysteine and Nitric Oxide Are Related to Blood Pressure and Vascular Function in Small-for-Gestational-Age Children

et al. 2007

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“…Lyall et al 20 reported that a higher concentration of total combined serum nitrite and nitrate was present in umbilical venous serum from pre-eclampsia. Higher plasma total nitrites were shown in IUGR 21 . Davidge et al…”

Section: Discussionmentioning

confidence: 88%

Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma from pregnancy with umbilical placental vascular disease

Wang¹

2003

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To determine whether endothelial cell injury would be produced by factor(s) released into the fetal circulation, manifested by altered messenger RNA expression of nitric oxide synthase. Design Case -control study.Setting University teaching hospital.Samples Fetal plasma was collected from 34 normal pregnancies, 44 pregnancies with umbilical placental vascular disease identified by an abnormal umbilical Doppler and 11 pregnancies with maternal pre-eclampsia but with normal umbilical Doppler studies. Methods Aliquots from a common culture of human umbilical vein endothelial cells (HUVECs) were incubated with fetal plasma from the members of the three patient groups. The total RNA was extracted from the endothelial cells and mRNA for nitric oxide synthase was measured by reverse transcription and semi-quantitative polymerase chain reaction (RT-PCR). This was standardised by comparison of the amplified inducible nitric oxide synthase (iNOS) or endothelial constitutive nitric oxide synthase (ecNOS) to glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Main outcome measure Endothelial cell gene expression of iNOS and ecNOS.Results The mRNA expression of iNOS and ecNOS were significantly higher ( P < 0.05) in HUVECs stimulated by fetal plasma from pregnancies with umbilical placental vascular disease [iNOS 1.12 (0.16); ecNOS 1.78 (0.18)] when compared with normal pregnancies [iNOS 0.56 (0.06); ecNOS 1.06 (0.10)]. In the maternal pre-eclampsia group, the NOS expression [iNOS 0.76 (0.11); ecNOS 1.39 (0.26)] did not differ from normal pregnancy. In the vascular disease group, there was no difference in NOS expression between the subgroups with and without maternal pre-eclampsia. Conclusions Our study demonstrates that umbilical placental vascular disease is associated with a factor(s) in fetal plasma that produces an increase in the expression of iNOS and ecNOS mRNA by endothelial cells. Our findings raise the possibility that the release of factors causing an up-regulation of iNOS and ecNOS in the endothelium in the fetal placenta may occur as part of an inflammatory response of the vascular endothelium to injury.

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“…The previous report showed that taurine transport is regulated by NO and the effect on taurine transporter activity by SIN-1 was not immediate (Bridges et al, 2001). Lyall et al (1996) demonstrated that ONOO-, which can be released from SIN-1, interacted with tyrosine residue of TauT. Also, the other reports showed that formation of nitrotyrosine was detected highly in NO donor treatment (Kulanthaivel et al, 1989;Myatt et al, 1996).…”

Section: Discussionmentioning

confidence: 95%

The Change of Taurine Transport in Variable Stress States through the Inner Blood-Retinal Barrier using In Vitro Model

Kang¹,

Lee²,

Chung³

2009

Biomolecules and Therapeutics

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-Taurine is the most abundant free amino acid in the retina and transported into retina via taurine transporter (TauT) at the inner blood-retinal barrier (iBRB). In the present study, we investigated whether the taurine transport at the iBRB is regulated by oxidative stress or disease-like state in a conditionally immortalized rat retinal capillary endothelial cell line (TR-iBRB) used as an in vitro model of iBRB.

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Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

Cited by 107 publications

References 27 publications

Homocysteine and Nitric Oxide Are Related to Blood Pressure and Vascular Function in Small-for-Gestational-Age Children

Homocysteine and Nitric Oxide Are Related to Blood Pressure and Vascular Function in Small-for-Gestational-Age Children

Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma from pregnancy with umbilical placental vascular disease

The Change of Taurine Transport in Variable Stress States through the Inner Blood-Retinal Barrier using In Vitro Model

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