Nitric oxide and thyroid hormone receptor alpha 1 contribute to ovarian follicular development in immature hyper- and hypo-thyroid rats

Zheng, Kaizhi; Sulieman, Fedail Jaafar; Li, Junrong; Wei, Quanwei; Xu, Mulin

doi:10.1016/j.repbio.2014.11.002

Cited by 20 publications

(17 citation statements)

References 29 publications

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“…Thyroid hormones are necessary for the normal development of the mammalian ovary (Fedail, Zheng, Wei, Kong, & Shi, ; Nelson, Allan, Pang, & Habibi, ) and have been demonstrated in follicular fluid. One of our previous studies exhibited that TRα1 was expressed and localized in oocytes, granulosa cells and theca cells during follicular development (Zheng et al, ); thyroid hormones can alter the release of gonadotropins, further affecting the destiny of the ovarian follicle (Sun et al, ). It has been reported that the imbalance in thyroid hormones leads to a significant reduction in ovarian weight, which is related to a disorder of reproductive hormone synthesis and secretion, and further increases the risk of infertility (Ding et al, ; Hapon, Gamarra‐Luques, & Jahn, ; Wei et al, ).…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A attenuates thyroxine‐induced apoptosis in ovarian granulosa cells of pigs

Song

Wei

et al. 2019

Reprod Domestic Animals

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Contents Bisphenol A (BPA) is a chemical of high production volume that is used widely in many industries and is known as a xenooestrogen and anti‐thyroid hormone endocrine disrupter. There is little information regarding the effects of BPA in the presence of thyroid hormone on porcine granulosa cell development. Thus, the primary granulosa cells were treated with thyroxine (T4, 10 nM), BPA (10 µM) or T4 plus BPA; we subsequently evaluated the effects of T4 or BPA on 17β‐estradiol synthesis, cellular proliferation and apoptosis. Our data showed that BPA significantly increased the accumulation of 17β‐estradiol and promoted granulosa cell proliferation, whereas T4 significantly decreased 17β‐estradiol and had no effect on cellular proliferation. In addition, it was noteworthy that T4 treatment induced apoptosis in porcine granulosa cells and BPA co‐incubation attenuated T4‐induced apoptosis as shown from flow cytometric assay analysis. We hypothesized that BPA attenuates T4‐induced apoptosis by regulating 17β‐estradiol accumulation and oestrogen receptor‐mediated signalling pathways. In conclusion, our results demonstrated that T4 affected 17β‐estradiol accumulation and induced cellular apoptosis, but did not affect granulosa cell proliferation. Exposure to BPA increased 17β‐estradiol accumulation, promoted granulosa cell proliferation and attenuated T4‐induced apoptosis in porcine granulosa cells in vitro.

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Section: Introductionmentioning

confidence: 99%

Bisphenol A attenuates thyroxine‐induced apoptosis in ovarian granulosa cells of pigs

Song

Wei

et al. 2019

Reprod Domestic Animals

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“…RNS, on the other side, are necessary for the development of large antral follicles [17,18], to stimulate meiotic maturation in oocytes [19,20], in the ovulatory process [21], in early folliculogenesis up to the maturation step [22] and in preimplantation embryonic development [23,24]. Additionally, RNS participate in sperm capacitation [25,26,27] and the acrosome reaction [28].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on Gamete Handling and In Vitro Embryo Production in Humans and Other Mammals

Loren

Sánchez

Arias

et al. 2017

IJMS

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Oxidative and nitrosative stress are common problems when handling gametes in vitro. In vitro development in mammalian embryos is highly affected by culture conditions, especially by reactive oxygen species (ROS) and reactive nitrogen species (RNS), because their absence or overproduction causes embryo arrest and changes in gene expression. Melatonin in gamete co-incubation during in vitro fertilization (IVF) has deleterious or positive effects, depending on the concentration used in the culture medium, demonstrating the delicate balance between antioxidant and pro-oxidant activity. Further research is needed to better understand the possible impact of melatonin on the different IVP steps in humans and other mammals, especially in seasonal breeds where this neuro-hormone system highly regulates its reproduction physiology.

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“…; Zheng et al . ), and they are widely expressed in different tissues and organs (Harvey & Williams ). TR α 1, TRv α 2 and TRv α 3 proteins were synthesized from TRα gene and they are differ in their carboxyl terminus.…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Wei

Fedail

Kong

et al. 2017

Animal Science Journal

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To expand our understanding of the roles of thyroid hormones on female reproduction, we induced hypo- and hyper-T rat models to investigate the roles of thyroid hormones on estrous cyclicity, as well as the antioxidative status in the ovaries of rats. In the current study, our data show that hypothyroidism (hypo-T) and hyperthyroidism (hyper-T) led to significantly reduced body weights and ovarain weights and delayed vaginal opening day. For hyper-T, thyroxine (T4), tri-iodothyronine (T3), progesterone (P4) and follicle-stimulating hormone (FSH) were significantly increased, while estradiol (E2) and luteinizing hormone (LH) were significantly decreased. For hypo-T rats, serum levels of total T4 and T3, E2, P4, FSH and LH were significantly increased, while concentrations of E2 and LH were significantly decreased. For ovary morphology, the numbers of secondary and antral follicles were significantly decreased with more atretic antral follicles and less corpora lutea in both hyper- and hypo-T groups. Both hyper-T and hypo-T treatment significantly decreased the expressions of thyroid hormone receptor α1 in the ovary. Hypo-T significantly reduced nitric oxide (NO), total NO synthase (tNOS), inducible NOS and constitutive NOS activities, but hyper-T increased them. For antioxidative parameters, hypo-T and hyper-T treatment significantly increased malondialdehyde (MDA) contents. The activities of both glutathione peroxidase (GSH-Px) and catalase (CAT) significantly decreased in the hypo-T group but increased in the hyper-T group. Total superoxide dismutase (T-SOD) activity was significantly increased in the hyper-T group. In summary, thyroid hormones alter estrous cyclicity and antioxidative status in the ovary of the rat may act through the NOS signaling pathway.

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Nitric oxide and thyroid hormone receptor alpha 1 contribute to ovarian follicular development in immature hyper- and hypo-thyroid rats

Cited by 20 publications

References 29 publications

Bisphenol A attenuates thyroxine‐induced apoptosis in ovarian granulosa cells of pigs

Bisphenol A attenuates thyroxine‐induced apoptosis in ovarian granulosa cells of pigs

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on Gamete Handling and In Vitro Embryo Production in Humans and Other Mammals

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

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