Nitric oxide and its role in apoptosis

Brüne, Bernhard; Knethen, Andreas von; Sandau, Katrin

doi:10.1016/s0014-2999(98)00274-x

Cited by 416 publications

(251 citation statements)

References 116 publications

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“…High levels of NO can directly damage DNA (Nguyen et al, 1992) and induce neuronal apoptosis (Brune et al, 1998;Constantin et al, 2002;Gahm et al, 2006). The reduction of NO and ROS production in rotenone-or MPP + -exposed neurons by LED further attests to the neuroprotective effect of near-infrared light treatment.…”

Section: Discussionmentioning

confidence: 91%

Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity

et al. 2008

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Parkinson's disease is a common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mitochondrial dysfunction has been strongly implicated in the pathogenesis of Parkinson's disease. Thus, therapeutic approaches that improve mitochondrial function may prove to be beneficial. Previously, we have documented that near-infrared light via light-emitting diode (LED) treatment was therapeutic to neurons functionally inactivated by tetrodotoxin, potassium cyanide (KCN), or methanol intoxication, and LED pretreatment rescued neurons from KCN-induced apoptotic cell death. The current study tested our hypothesis that LED treatment can protect neurons from both rotenone-and MPP + -induced neurotoxicity. Primary cultures of postnatal rat striatal and cortical neurons served as models, and the optimal frequency of LED treatment per day was also determined. Results indicated that LED treatments twice a day significantly increased cellular ATP content, decreased the number of neurons undergoing cell death, and significantly reduced the expressions of reactive oxygen species and reactive nitrogen species in rotenone-or MPP + -exposed neurons as compared to untreated ones. These results strongly suggest that LED treatment may be therapeutic to neurons damaged by neurotoxins linked to Parkinson's disease by energizing the cells and increasing their viability.

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Section: Discussionmentioning

confidence: 91%

Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity

et al. 2008

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“…It is interesting to note that inhaled smaller quantities of NO may also inhibit apoptosis. 30,31,32 Inhalation of NO (10 p.p.m. ), in addition to having a beneficial effect on hemodynamics and oxygenation in newborn lungs, also significantly inhibited cell death by apoptosis.…”

Section: Oxygen Radicals In Apoptosismentioning

confidence: 99%

Studies of meconium-induced lung injury: inflammatory cytokine expression and apoptosis

Vidyasagar

Zagariya

2008

J Perinatol

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To review current literature related to cellular mechanisms of meconiuminduced lung injury (MILI). Review of published experimental in vitro and in vivo MAS studies using human and animal lung cells. We found that meconium induces expression of cytokines and angiotensin II (ANG II)-induced apoptotic process in the lung cells. We postulate that inflammatory cytokines induce ANG II expression, which causes apoptotic cell death after binding to its AT1 receptors. We also demonstrated expression of serpins associated with meconium instillation into the lungs. Serpins are proteins that inhibit cellular proteases and elastases. Expression of serpins may be an attempt to recover lung from these injurious effects. In summary our studies show that whereas meconium induces inflammatory cytokines and subsequent cell apoptosis, the lung cells also try to protect themselves by inducing serpins. The balance of these interactions will determine the residual damage. We believe these new findings are very important in understanding of MILI.

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“…[3][4][5][6] At first glance, pro-apoptotic effects seem to be associated with pathophysiological conditions and with high output NO production by iNOS, whereas the continuous release of low output NO via constitutive NOS would lead to protection. The present review will try to summarize the effects of NO on human leukemic cell apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms involved in the pro- and anti-apoptotic role of NO in human leukemia

2000

Leukemia

129

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Nitric oxide and its role in apoptosis

Cited by 416 publications

References 116 publications

Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity

Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity

Studies of meconium-induced lung injury: inflammatory cytokine expression and apoptosis

Mechanisms involved in the pro- and anti-apoptotic role of NO in human leukemia

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