Nitric oxide and hormesis

Calabrese, Edward J.; Agathokleous, Evgenios; Dhawan, Gaurav; Kapoor, Rachna; Dhawan, Vikas; Manes, Prabhjot; Calabrese, Vittorio

doi:10.1016/j.niox.2023.02.001

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No Is a Regulator Of Heme Allocation In Biology1

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Cited by 6 publications

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“…Moreover, the biphasic NO response that cells exhibit regarding their heme allocation, in which lower concentrations are beneficial while higher concentrations have a negative impact, reflects a hormesis that is also observed for many other biological NO responses. [ 38 ] Overall, these concepts have fundamental implications for biology and medicine that should be further investigated.…”

Section: No Is a Regulator Of Heme Allocation In Biologymentioning

confidence: 99%

A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution

et al. 2023

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A natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration-dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.

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Section: No Is a Regulator Of Heme Allocation In Biologymentioning

confidence: 99%