Nitric Oxide and Cardiovascular Diseases: Cardioprotection, Complications and Therapeutics

Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy

“…Furthermore, NO can activate guanylate cyclase to synthesize cyclic guanosine monophosphate (cGMP) and inhibit type 5 phosphodiesterase (PDE5). Through these mechanisms, elevated cGMP levels can induce vasodilation at the site of administration, accelerate blood flow, and modify the local tissue microcirculation system, thereby potentially facilitating efficient drug penetration into the skin [ 23 , 24 ]. In recent years, our research group has conducted a series of studies on the efficient loading and combination therapy of NO, constructing various NO carrier materials for disease treatment and achieving promising results [ [25] , [26] , [27] ].…”