Nitric oxide and bone: The phoenix rises again

Liu, Hanghang; Rosen, Clifford J.

doi:10.1172/jci147072

Cited by 7 publications

(5 citation statements)

References 20 publications

(19 reference statements)

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“…Exogenous NO liberated by osteoblasts and osteocytes avoids osteoclast attachment and resorption. Conversely, NO produced by osteoclasts has dual effects on osteoclasts, depending on constitutive or inducible NOS activity [ 64 ]. IFN-γ induction of NOS by cells in the marrow leads to the suppression of osteoclastogenesis, whereas constitutive NOS activity stimulates bone resorption [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative-Stress-Related Genes in Osteoporosis: A Systematic Review

et al. 2023

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Osteoporosis is characterized by a decline in bone mineral density (BMD) and increased fracture risk. Free radicals and antioxidant systems play a central role in bone remodeling. This study was conducted to illustrate the role of oxidative-stress-related genes in BMD and osteoporosis. A systematic review was performed following the PRISMA guidelines. The search was computed in PubMed, Web of Sciences, Scopus, EBSCO, and BVS from inception to November 1st, 2022. The risk of bias was evaluated using the Joanna Briggs Institute Critical Appraisal Checklist tool. A total of 427 potentially eligible articles exploring this search question were detected. After removing duplicates (n = 112) and excluding irrelevant manuscripts based on screenings of their titles and abstracts (n = 317), 19 articles were selected for full-text review. Finally, 14 original articles were included in this systematic review after we applied the exclusion and inclusion criteria. Data analyzed in this systematic review indicated that oxidative-stress-related genetic polymorphisms are associated with BMD at different skeletal sites in diverse populations, influencing the risk of osteoporosis or osteoporotic fracture. However, it is necessary to look deep into their association with bone metabolism to determine if the findings can be translated into the clinical management of osteoporosis and its progression.

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Section: Discussionmentioning

confidence: 99%

Oxidative-Stress-Related Genes in Osteoporosis: A Systematic Review

et al. 2023

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“…It has been suggested that NO generated by inducible NOS (iNOS) can inhibit osteoclastogenesis while NO generated by constitutive NOS (cNOS) promotes this process [ 39 ]. Additionally, exogenous NO can prevent the function of osteoclasts [ 40 ]. In our study, we found that eicosenoate was positively correlated with NOS, but no significant correlation was found between these fatty acids and NO.…”

Section: Discussionmentioning

confidence: 99%

Changes in Bone Marrow Fatty Acids Early after Ovariectomy-Induced Osteoporosis in Rats and Potential Functions

et al. 2022

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The aim of this study was to investigate the changes in bone marrow fatty acids early after ovariectomy-induced osteoporosis in rats, and explore the potential function of the bone marrow fatty acids. Ninety-six female Sprague Dawley rats (12 weeks) were randomly divided into an ovariectomized (OVX) group and Sham group (N = 48/group) and received ovariectomy or Sham surgery, respectively. After 3, 5, 7,14, 21 and 28 days, eight rats in each group were sacrificed to detect the composition of bone marrow fatty acids by means of gas chromatography-mass spectrometry and evaluate the trabecular bone microarchitecture by means of microCT. Bone marrow rinsing fluid and serum were collected for the detection of nitric oxide synthase/nitric oxide (NOS/NO) and bone metabolism related parameters, respectively. Our results demonstrated that the bone microstructure was damaged significantly from 14 days after OVX surgery onwards. Sample clustering and group separation were observed between the OVX group and Sham group 3 and 14 days after surgery, which suggested the role of bone marrow fatty acids in the early stage of postmenopausal osteoporosis. Palmitoleate, myristate and arachidonate were found to play an important role in classification between the OVX group and Sham group on the 3rd day after surgery (VIP > 1, p < 0.05). Palmitoleate, myristate, alpha linolenate, stearate and eicosenoate were found to play an important role in classification between the OVX group and Sham group on the 14th day after surgery (VIP > 1, p < 0.05). The levels of myristate, palmitoleate, alpha linolenate and eicosenoate were significantly decreased in the OVX group, while the levels of arachidonate and stearate were significantly increased in OVX group (p < 0.05). Additionally, myristate, palmitoleate, alpha linoleate and eicosenoate were negatively correlated with C-terminal telopeptide of type 1 collagen (CTX-1, a bone resorption marker), while arachidonate was negative correlated with osteocalcin (OCN, a bone formation marker) (p < 0.05). A significant correlation was also found between eicosenoate and NOS (p < 0.05). Profound bone marrow fatty acids changes have taken place in the early stage of post-menopausal osteoporosis. They may affect bone formation though affecting the differentiation and function of osteoclasts or osteoblasts, respectively. The NOS/NO system may mediate the influence of eicosenoate on bone formation.

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“…While these isoforms convert the same substrates, they have diverse expression profiles, activators, and repressors, leading to disparate functions in bone. Nitric oxide has long been understood to play an intrinsic role in bone homeostasis, but the translational potential of nitric oxide for bone mass has not been clarified ( Liu and Rosen, 2021 ).…”

Section: Molecular Signals Mediate the Cellular Effects Of Mechanical...mentioning

confidence: 99%

Osteocyte-mediated mechanical response controls osteoblast differentiation and function

Buck,

Stains

2024

Front. Physiol.

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Low bone mass is a pervasive global health concern, with implications for osteoporosis, frailty, disability, and mortality. Lifestyle factors, including sedentary habits, metabolic dysfunction, and an aging population, contribute to the escalating prevalence of osteopenia and osteoporosis. The application of mechanical load to bone through physical activity and exercise prevents bone loss, while sufficient mechanical load stimulates new bone mass acquisition. Osteocytes, cells embedded within the bone, receive mechanical signals and translate these mechanical cues into biological signals, termed mechano-transduction. Mechano-transduction signals regulate other bone resident cells, such as osteoblasts and osteoclasts, to orchestrate changes in bone mass. This review explores the mechanisms through which osteocyte-mediated response to mechanical loading regulates osteoblast differentiation and bone formation. An overview of bone cell biology and the impact of mechanical load will be provided, with emphasis on the mechanical cues, mechano-transduction pathways, and factors that direct progenitor cells toward the osteoblast lineage. While there are a wide range of clinically available treatments for osteoporosis, the majority act through manipulation of the osteoclast and may have significant disadvantages. Despite the central role of osteoblasts to the deposition of new bone, few therapies directly target osteoblasts for the preservation of bone mass. Improved understanding of the mechanisms leading to osteoblastogenesis may reveal novel targets for translational investigation.

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Nitric oxide and bone: The phoenix rises again

Cited by 7 publications

References 20 publications

Oxidative-Stress-Related Genes in Osteoporosis: A Systematic Review

Oxidative-Stress-Related Genes in Osteoporosis: A Systematic Review

Changes in Bone Marrow Fatty Acids Early after Ovariectomy-Induced Osteoporosis in Rats and Potential Functions

Osteocyte-mediated mechanical response controls osteoblast differentiation and function

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