Nitric oxide: An overview

Rodeberg, David A.; Chaet, Mark S.; Bass, R C; Arkovitz, Marc S.; Garcia, Victor F.

doi:10.1016/s0002-9610(05)80017-0

Cited by 144 publications

(68 citation statements)

References 123 publications

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“…38 NO, a water-and lipid-soluble free radical, is generated from Larginine by the action of NO syntheses (NOS). Ischemia causes an increase in NOS activity in the vascular endothelium and there appears in a range of cells including infiltrating neutrophils and macrophages.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Somuncu¹,

Çakmak²,

Erdoğan³

et al. 2006

Int J of Urology

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Objective: We aimed to detect the preventive effects of trapidil in ischemia-reperfusion (IR) injury due to testicular torsion and detorsion. Methods: Forty prepubertal albino rats were used. In the IR group, torsion was created by rotating the left testis over 2 h, and detorsion was done by untwisting the testis. Bilateral orchiectomies were performed after 4 h. In study group, 2-h torsion was performed and trapidil was administered as a single dose 1 h before detorsion. Bilateral orchiectomies were performed after 4 h. In the sham group, a sham operation was done. In the sham plus trapidil group, a sham operation was done and trapidil was administered as a single dose. Testicular tissue malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl (T-SH) levels were determined for each group. The grades of interstitial injury were determined in histopathologic examination. Results: The NO and MDA levels in the IR group were significantly higher than the study, sham and sham plus trapidil groups in the left testis (P < 0.05, P < 0.001 and P < 0.001, respectively). A statistical difference was not found among study, sham and sham plus trapidil groups in the left testis in NO and MDA levels (P > 0.05). The T-SH level in the study group was significantly higher than in the IR, sham and sham plus trapidil groups in left testis P < 0.05). In the IR group (left testis), grade 1 interstitial injury was 30% (3/10), grade 2 injury was 60% (6/10) and grade 3 injury was 10% (1/10). In the study group (left testis), grade 1 interstitial injury was 30% (3/10) and there was no injury in 70% (7/10). Conclusion: Trapidil decreased free oxygen radical formation in testicular torsion and detorsion, and attenuated histopathological damage in the ipsilateral twisted testis.

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Section: Discussionmentioning

confidence: 99%

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Somuncu¹,

Çakmak²,

Erdoğan³

et al. 2006

Int J of Urology

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“…Nitric oxide (NO) is a free gaseous radical (Frean et al, 1997) with a very short half-life (D'Acquisto et al, 1997) of 3 to 5 sec (Rodeberg et al, 1995). This gas causes smooth muscle relaxation (D'Acquisto et al, 1997), including the uterus (Bani et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…This gas causes smooth muscle relaxation (D'Acquisto et al, 1997), including the uterus (Bani et al, 1999). NO synthesis occurs with the oxidation of Larginine (Rodeberg et al, 1995) by the action of the enzyme nitric oxide synthase (NOS). The enzyme NOS converts the terminal guanidine group of L-arginine in NO (Rodeberg et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis

Wolf¹,

Malschitzky²,

Bustamante‐Filho³

et al. 2016

Anim Reprod

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“…However, the addition of too much Arg to the diet of broiler chicks is not associated with any significant changes in the weight of lymphoid organs or plasma antibody concentrations of those vaccinated against Newcastle disease virus (ND) (Kidd et al 2001). Nitric oxide synthesized from Arg, an endogenous donor of NO, by nitric oxide synthase (NOS) enzyme shows toxic effect for microorganism by binding some enzymes in bacterial cell wall which are critical for the life cycle of the microorganism (Rodeberg et al 1995). The infection capability of some microorganisms such as Mycobacterium avium is related to resistance of bacteria to NO (McCall et al 1991).…”

Section: Introductionmentioning

confidence: 99%

The effect of dietary L-arginine intake on the level of antibody titer, the relative organ weight and colon motility in broilers

Bülbül¹,

Özdemir²,

Bülbül³

et al. 2014

Polish Journal of Veterinary Sciences

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This study was carried out to determine the effect of L-arginine (L-Arg) levels in diet at the starter, grower and finisher phases on immune response, organ development, nitric oxide (NO) metabolism and colon motility in broilers. A total of 500 one-day-old Ross-308 broiler chickens of mixed sex were separated into one Arg-deficient group and four experimental groups. Each group was then divided into five subgroups of 20 birds each. Arginine deficient group for all phases was fed a basal diet which contained 10% less L-Arg than optimum Arg requirement recommended by the breeder. Experimental groups were fed a basal diet supplemented with L-Arg which was progressively 10% increased in groups. Thus, the diet contained 90, 100, 110, 120 and 130% of optimum Arg requirement for each phases in groups, respectively.The highest serum infectious bursal disease antibody titer (IBD) was observed in the experimental group which was fed the diet containing 110% L-Arg at grower phase (P<0.05), whereas Newcastle disease antibody titer did not differ between groups. The relative weight of spleen increased in groups which were fed the diet containing 120 and 130% L-Arg at starter phase as compared to Arg-deficient group (P<0.05). The group which was fed the diet containing 110% L-Arg showed highest relative weight of bursa Fabricii at grower (P<0.05) and finisher (P<0.01) phases. It was observed that serum nitric oxide (NO) concentration decreased in Arg-deficient group (P<0.05). The amplitude of spontaneous colon contractility did not differ between groups at the end of all three phases. However, the frequency of spontaneous colon contractility in the Arg deficient group was higher at starter (P<0.05), grower (P<0.01) and finisher (P<0.05) phases.These results suggest that the supplementation of L-Arg at higher level than optimum Arg requirement in broiler diet has minimal effect on parameters investigated in the study. However, L-Arg-deficiency may negatively affect immune response and the motility of gastrointestinal system due to disruption of NO metabolism at three phases.

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Nitric oxide: An overview

Cited by 144 publications

References 123 publications

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis

The effect of dietary L-arginine intake on the level of antibody titer, the relative organ weight and colon motility in broilers

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