Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease

Gupta, Parul; Kumar, Ravindra

doi:10.1016/j.niox.2024.01.008

Cited by 2 publications

(1 citation statement)

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“…Nitric oxide (NO) deficiency has been shown to play an important role in the development of vaso-occlusive crises, a characteristic feature of SCD [188]. Accordingly, clinical trials and studies have suggested the importance of artificial NO induction in relation to a reduction in the severity of the disease [195]. In this respect, Weiner et al [196] reported a preliminary study suggesting that inhaled NO may be beneficial for acute vaso-occlusive crises in SCD [196].…”

Section: Inducers Of Nitric Oxide In Scdmentioning

confidence: 99%

Pharmacogenomics of Drugs Used in β-Thalassemia and Sickle-Cell Disease: From Basic Research to Clinical Applications

Gambari,

Waziri,

Goonasekera

et al. 2024

IJMS

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In this short review we have presented and discussed studies on pharmacogenomics (also termed pharmacogenetics) of the drugs employed in the treatment of β-thalassemia or Sickle-cell disease (SCD). This field of investigation is relevant, since it is expected to help clinicians select the appropriate drug and the correct dosage for each patient. We first discussed the search for DNA polymorphisms associated with a high expression of γ-globin genes and identified this using GWAS studies and CRISPR-based gene editing approaches. We then presented validated DNA polymorphisms associated with a high HbF production (including, but not limited to the HBG2 XmnI polymorphism and those related to the BCL11A, MYB, KLF-1, and LYAR genes). The expression of microRNAs involved in the regulation of γ-globin genes was also presented in the context of pharmacomiRNomics. Then, the pharmacogenomics of validated fetal hemoglobin inducers (hydroxyurea, butyrate and butyrate analogues, thalidomide, and sirolimus), of iron chelators, and of analgesics in the pain management of SCD patients were considered. Finally, we discuss current clinical trials, as well as international research networks focusing on clinical issues related to pharmacogenomics in hematological diseases.

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