Nitration of alkaloids from carex parvae

Synthesis of Enantiomerically Pure (−)-(S)-Brevicolline

“…The β-carboline alkaloid brevicolline ( 1 ), the major alkaloid of the plant Carex brevicollis DC (Cyperacee), belongs to a group of pharmacologically interesting compounds and was isolated, , determined, and chemically modified 30 years ago. Since that time, syntheses of racemic 1 were carried out, for example, by Winterfeldt or Leete, both using tryptamine as starting compound.…”

“…The reported effects of these compounds include antineoplastic (tubuline binding), [2][3][4] anticonvulsive, hypnotic and anxiolytic (benzodiazepine receptor inhibitoric), 2,5-8 antiviral, 9 antimicrobial, 3 and topoisomerase II inhibition 10 and inhibition of cGMP-dependent processes. 11 The β-carboline alkaloid brevicolline (1), the major alkaloid of the plant Carex brevicollis DC (Cyperacee), belongs to a group of pharmacologically interesting compounds 12 and was isolated, 13,14 determined, 15 and chemically modified 16 30 years ago. Since that time, syntheses of racemic 1 were carried out, for example, by Winterfeldt 17 or Leete, 18 both using tryptamine as starting compound.…”

Synthesis and isolation of nitro‐bT‐carbolines obtained by nitration of commercial β‐carboline alkaloids

“…This paper includes the description of the ir spectrum of each compound. Besides, there are some papers which describe that by treatment of harmane with nitric acid the 6-nitroharmane was prepared in order to study several properties by using the uv spectra [31,[45][46][47]. Among them, only in references 45 and 46 are the mp's of the prepared nitro-harmane reported as proof of characterization.…”