“…1 have exhibited extensive research interest in a number of areas, such as catalysis, [4][5][6] adsorption, 7,8 ion exchange, 4,9 and especially in drug delivery system as a novel biomaterials 1,[10][11][12] due to their low cost, ease of preparation, ion-exchange property, low cytotoxicity, and high biocompatibility. 1,13,14 Ambrogi et al 10 reported that the loosely flocculated ibuprofen (IBU)-intercalated Mg-Al-LDH nanoparticles (\200 nm) obtained by ion-exchange with chloride intercalated Mg-Al-LDH precursor showed almost 80% of IBU released only after 30 min ascribed to a dissolution mechanism.…”