Nitrate’s Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction Trial

Zakeri, Rosita; Levine, James A.; Koepp, Gabriel A.; Borlaug, Barry A.; Chirinos, Julio A.; LeWinter, Martin M.; VanBuren, Peter; Dávila‐Román, Víctor G.; Fuentes, Lisa de las; Khazanie, Prateeti; Hernandez, Adrian F.; Anstrom, Kevin J.; Redfield, Margaret M.

doi:10.1161/circheartfailure.114.001598

Cited by 30 publications

(28 citation statements)

References 79 publications

(86 reference statements)

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“…Nitrates are an alternative that might accomplish the same goal of increasing both titin and MyBP-C phosphorylation. The results of the ongoing Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction (NEAT) trial of the effects of isosorbide mononitrate on exercise capacity in HFpEF 49 are therefore eagerly anticipated.…”

Section: Implications For Human Disease and Future Directionsmentioning

confidence: 99%

Updating the Physiology and Pathophysiology of Cardiac Myosin-Binding Protein-C

LeWinter

Palmer

2015

Circ: Heart Failure

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Section: Implications For Human Disease and Future Directionsmentioning

confidence: 99%

Updating the Physiology and Pathophysiology of Cardiac Myosin-Binding Protein-C

LeWinter

Palmer

2015

Circ: Heart Failure

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“…In contrast, there is no tolerance with inorganic nitrite, and, because conversion of nitrite to NO occurs preferentially during exercise, there may be less sodium retention and less risk of excessive BP reduction at rest, which can be problematic in those with HFpEF(15). The effect of organic nitrates on activity tolerance and exercise capacity is currently being investigated in the NEAT-HFpEF (Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction) trial(38). LIMITATIONS.…”

mentioning

confidence: 99%

Sodium Nitrite Improves Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction

Borlaug

Koepp

Melenovský

2015

Journal of the American College of Cardiology

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191

163

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“…These devices capture patients overall daily functional capacity in a more "holistic manner" because they reflect longitudinal changes rather than episodically assessments. The clinical feasibility of activity assessment by wearable accelerometers has already been shown in clinical trials [39].…”

Section: Monitoring Effects Of Therapeutic Interventionsmentioning

confidence: 99%

Molecular and Digital Biomarker Supported Decision Making in Clinical Studies in Cardiovascular Indications

Dinh

2016

Archiv der Pharmazie

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Although a large number of pharmaceutical therapies are available to treat cardiovascular diseases like heart failure, in many medical conditions treatment is still not optimal and, therefore, the need for innovative, safe and efficacious drugs is still very high in this indication. Biomarkers are an important tool in the preclinical and clinical drug development process; they allow patient selection for clinical studies as well as therapy monitoring during studies. Biomarker concepts in cardiovascular indications differ very much from those in oncology and are very diverse. The present article gives an overview of the pathomechanisms of heart failure and describes the socioeconomic impact of the disease and the biomarker strategies being applied in the development of new heart failure drugs. The focus lies on protein biomarkers that can be measured in the blood and on functional biomarkers that can be derived from implanted and wearable medical devices.

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Nitrate’s Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction Trial

Cited by 30 publications

References 79 publications

Updating the Physiology and Pathophysiology of Cardiac Myosin-Binding Protein-C

Updating the Physiology and Pathophysiology of Cardiac Myosin-Binding Protein-C

Sodium Nitrite Improves Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction

Molecular and Digital Biomarker Supported Decision Making in Clinical Studies in Cardiovascular Indications

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