Nitazoxanide in aqueous co-solvent solutions of isopropanol/DMF/NMP: Solubility, solvation thermodynamics and intermolecular interactions

Solubility Determination and Thermodynamic Model Analysis of Adefovir in Different Solvents from 278.15 to 328.15 K

“…This may be attributed to the fact that DMF is an aprotic solvent; its molecular structure lacks hydrogen bond donors, thereby significantly reducing the inhibitory effect of solvent–solvent interactions on solubility. Additionally, DMF has a certain ability to accept hydrogen bonds, which also enhances the solubility of AF in this solvent to some extent, consistent with the analysis of the solvent effect’s influence presented below . The solubility of AF is the lowest in toluene.…”

“…Additionally, DMF has a certain ability to accept hydrogen bonds, which also enhances the solubility of AF in this solvent to some extent, consistent with the analysis of the solvent effect's influence presented below. 29 The solubility of AF is the lowest in toluene. In some solvents, the solubility order follows the polarity order: methanol > n-propanol > isobutyl alcohol > toluene.…”

Unveiling the origin of the efficient photocatalytic degradation of nitazoxanide over bismuth (oxy)iodide crystalline phases

“…23 The –NO 2 and –NH groups are the principal sites of electrophilic and nucleophilic attacks on the nitazoxanide molecule, respectively. 23 The presence of conjugated double bonds and nitro and amide groups being chromophores indicates that the nitazoxanide molecule should be susceptible to light. 24 During the photocatalytic process, the nitazoxanide molecule underwent decomposition via hydrolysis into acetylsalicylic acid (1) and the respective aminonitrothiazol (2) (Fig.…”

“…22 The extensive use of nitazoxanide for treating various diseases, including cryptosporidiosis, resulted in the detection of its traces in wastewater matrices due to its persistence, which stems from its poor permeability and solubility (7.55 mg L −1 ). 23 Therefore, it is important to find a novel approach to efficiently remove it from contaminated water and wastewater. So far, no studies have been conducted to investigate the photocatalytic removal of nitazoxanide except for via photolysis.…”

Mechanistic study of the formation of arbutin polymorphs and solvates

“…6 Due to the variety of solvent-related operations during the manufacturing process of drugs, the formation of solvates in the pharmaceutical industry is very common. [7][8][9][10][11] Different solvates generally exhibit diverse physical and chemical properties, which would further affect the follow-up treatment of drugs. Further, some solvates have the tendency to transform into other forms or even crystallize simultaneously with other polymorphs.…”